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New molecular insights on medical cannabis

Drug Target Review

2012 Feb 1;40(1):31–6. Role of autotaxin in cancer stem cells. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. Biochemical Society Transactions. Lee D, Suh DS, Lee SC, et al. Cancer Metastasis Rev.

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Building better brain models for Parkinson’s disease and beyond

Drug Target Review

Turning this tide, Professor Jens Christian Schwamborn, a cell biology expert at the University of Luxembourg and co-founder of OrganoTherapeutics , is leading a groundbreaking effort to transform our understanding and treatment of these debilitating diseases. But it turned out I was completely wrong. It’s incredibly complex.”

Disease 52
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Cancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance

Drug Target Review

Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology. 2012 Feb 1;24(1):107-15. Biophysical Journal. 2021 Jul 6;120(13):2644-56. Springer TA, Dustin ML. Integrin inside-out signaling and the immunological synapse.

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Precision Medicine in the Genomic Era

DrugBank

13 , 1–27 (2012). Network expansion of genetic associations defines a pleiotropy map of human cell biology. . & Barbadilla, A. Molecular Population Genetics. Genetics 205 , 1003–1035 (2017).  Olson, M. Human Genetic Individuality. Genomics Hum.  Johansson, Å et al.

Disease 98
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TACACICLIB, AUR-102, AURIGENE

New Drug Approvals

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

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2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy

Broad Institute

A similar CAR from another company, Kite Pharmaceuticals (now a Gilead company), was approved by the FDA in 2017 as the second commercial CAR T-cell therapy. In 2010, cells grown by June and Levine were used to treat leukemia and lymphoma patients. A single dose of the engineered cells wiped out signs of disease.

Therapies 119
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Obstacles and innovations of macrocyclic drug development

Drug Target Review

She has a PhD in Microbiology and Cell Biology from the University of Illinois, followed by work in biochemistry as a post-doctoral fellow at UCSF. Advanced Drug Delivery Reviews , 64:417, 2012. Ajay N Jain Ajay is VP of Research for the Optibrium s BioPharmics Division. References Lipinski CA, Lombardo F, Dominy BW, Feeney PJ.