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Gamcemetinib

New Drug Approvals

nM) and cell based assays ( EC 50 =89 nM). nM) and cell based assays ( EC 50 =89 nM). Gamcemetinib CAS 1887069-10-4 CC-99677 , OS2IR8TV1O Molecular Weight 469.94 Gamcemetinib CAS 1887069-10-4 CC-99677 , OS2IR8TV1O Molecular Weight 469.94 Gamcemetinib is extracted from patent WO2020236636, compound 1.

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Time for change: non-human primates in drug research

Drug Target Review

7 This initiative forms part of a broader effort to modernise drug development and align regulatory expectations with emerging new approach methodologies (NAMs), including human cell-based assays, artificial intelligence models and organ-on-chip platforms. Federal ruling on USDA primate welfare petition, 2023.

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New image-based cellular profiling tool peers deeply into metabolic biology

Broad Institute

Cell Genomics. Online June 20, 2023. 2023.100346 Tags: Imaging Metabolism Program Connecting variants to functions Cardiovascular disease Diabetes Obesity Heart Disease Image-Based Profiling Papers cited Laber S, Strobel SM, et al. DOI: 10.1016/j.xgen.2023.100346

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Altasciences Completes Expansion of New State-Of-The-Art Laboratory in Columbia, Missouri

Alta Sciences

Altasciences Completes Expansion of New State-Of-The-Art Laboratory in Columbia, Missouri pmjackson Tue, 10/31/2023 - 16:08 Laval, Québec, October 31, 2023 – Altasciences is pleased to announce the completion of its laboratory facilities in Columbia, MO. All three laboratories across North America are uniformly designed and managed.

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Separating the Hype from the Hyperbole Surrounding FDORA’s Alternatives to Animal Testing under the FD&C Act

FDA Law Blog: Drug Discovery

The definition goes on to list potential options for such tests: cell-based assays, organ chips and microphysiological systems, computer modeling, other nonhuman or human biology-based test methods such as bioprinting, as well as animal tests. FDORA § 3209(a)(2).

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tk

Broad Institute

tk By makenziekohler June 23, 2023 Breadcrumb Home tk LipocyteProfiler, an adaptation of Cell Painting, explores cell shape, structure, and biological processes together.

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Chemical con artists foil drug discovery

Molecular Design

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

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