2023 and Cell Based Assays - Drug Discovery Digest

Time for change: non-human primates in drug research

Drug Target Review

JULY 7, 2025

7 This initiative forms part of a broader effort to modernise drug development and align regulatory expectations with emerging new approach methodologies (NAMs), including human cell-based assays, artificial intelligence models and organ-on-chip platforms. Federal ruling on USDA primate welfare petition, 2023.

Drug Research

Drug Research Research Animal Testing Drugs

Gamcemetinib

New Drug Approvals

JUNE 5, 2025

nM) and cell based assays ( EC 50 =89 nM). nM) and cell based assays ( EC 50 =89 nM). Gamcemetinib CAS 1887069-10-4 CC-99677 , OS2IR8TV1O Molecular Weight 469.94 Gamcemetinib CAS 1887069-10-4 CC-99677 , OS2IR8TV1O Molecular Weight 469.94 Gamcemetinib is extracted from patent WO2020236636, compound 1.

Cell Based Assays

Cell Based Assays Clinical Pharmacology Pharmacokinetics Trials

New image-based cellular profiling tool peers deeply into metabolic biology

Broad Institute

JUNE 30, 2023

Cell Genomics. Online June 20, 2023. 2023.100346 Tags: Imaging Metabolism Program Connecting variants to functions Cardiovascular disease Diabetes Obesity Heart Disease Image-Based Profiling Papers cited Laber S, Strobel SM, et al. DOI: 10.1016/j.xgen.2023.100346

Small Molecule

Small Molecule Cell Based Assays Disease Assay Development

Altasciences Completes Expansion of New State-Of-The-Art Laboratory in Columbia, Missouri

Alta Sciences

OCTOBER 31, 2023

Altasciences Completes Expansion of New State-Of-The-Art Laboratory in Columbia, Missouri pmjackson Tue, 10/31/2023 - 16:08 Laval, Québec, October 31, 2023 – Altasciences is pleased to announce the completion of its laboratory facilities in Columbia, MO. All three laboratories across North America are uniformly designed and managed.

Laboratories

Laboratories Clinical Pharmacology Cell Based Assays Drug Development

Separating the Hype from the Hyperbole Surrounding FDORA’s Alternatives to Animal Testing under the FD&C Act

FDA Law Blog: Drug Discovery

FEBRUARY 2, 2023

The definition goes on to list potential options for such tests: cell-based assays, organ chips and microphysiological systems, computer modeling, other nonhuman or human biology-based test methods such as bioprinting, as well as animal tests. FDORA § 3209(a)(2).

Animal Testing

Animal Testing Biosimilars Cell Based Assays Clinical Trials

tk

Broad Institute

JUNE 21, 2023

tk By makenziekohler June 23, 2023 Breadcrumb Home tk LipocyteProfiler, an adaptation of Cell Painting, explores cell shape, structure, and biological processes together.

Small Molecule

Small Molecule Cell Based Assays Medical Schools Disease

Chemical con artists foil drug discovery

Molecular Design

DECEMBER 31, 2023

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs

Drugs Packaging Cell Based Assays Small Molecule

AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Elrig

APRIL 29, 2024

Fascinated by the potential of AI in medical research, I transitioned to BenevolentAI in early 2023 as a Biology Project Leader. This involved designing and implementing biological strategies, encompassing target validation, hit identification, establishing assays, and collaborating on structural work.

Bioinformatics

Bioinformatics Drugs Molecular Biology Cell Based Assays

Article FDA Thank You Draft guidance on potency assays for CGT products garners extensive stakeholder input

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production

Production FDA Therapies Biochemical Assays

ChEMBL 34 is out!

The ChEMBL-og

APRIL 16, 2024

Zimmermann Lab Biotransformation data Dec 2023 (src_id = 69): 271 compounds have been tested for biotransformation in 68 bacterial species and 28 bacterial communities. 71 out of the 882 newly added EMA drugs are only authorised by EMA, rather than from other regulatory bodies e.g. FDA. University of Dundee: T.

Clinical Trials

Clinical Trials FDA Cell Based Assays Compound Screening

A Bioanalysis Partner You Can Trust

Alta Sciences

AUGUST 9, 2023

A Bioanalysis Partner You Can Trust shajjar Wed, 08/09/2023 - 09:00 HTML At Altasciences, we specialize in diverse immunomodulators, including proteins, oligonucleotides, biologics, bispecific antibodies, and gene therapy.