2025 - Drug Discovery Digest

How AI will reshape pharma by 2025

Drug Target Review

DECEMBER 20, 2024

Looking ahead, 2025 could represent a major turning point for the pharmaceutical sector. In 2025, I think well see breakthroughs that allow us to make significant advances in rare diseases, where the data is small. While current breakthroughs are impressive, Smith anticipates even greater advancements by 2025.

Clinical Trials

Clinical Trials Trials Pharmaceuticals Drug Development

CDD Vault Update (July 2025): Custom Axis Scaling, AUC Fold Change, Copy Reactions and Stoichiometry Tables, and Sample Tracking Improvements for the ELN

Collaborative Drug

JULY 10, 2025

CDD Vault Update (July 2025): Custom Axis Scaling, AUC Fold Change, Copy Reactions and Stoichiometry Tables, and Sample Tracking Improvements for the ELN

CDD Vault Update (July #2 2025) Search Inventory by Molecule & Batch Fields, Protocol Plate Locations, Stoichiometry Table Debiting, Synonym Links in ELN, Chemical Properties in Structure Editor

Collaborative Drug

JULY 24, 2025

CDD Vault Update (July #2 2025) Search Inventory by Molecule & Batch Fields, Protocol Plate Locations, Stoichiometry Table Debiting, Synonym Links in ELN, Chemical Properties in Structure Editor

Ubrogepant (Ubrelvy) Effective Against Early Migraine Symptoms

Drugs.com

MAY 14, 2025

WEDNESDAY, May 14, 2025 -- Migraines don’t just cause headaches. These attacks often are accompanied by symptoms like light and sound sensitivity, nausea, neck pain and dizziness. What’s more, those non-headache symptoms tend to crop.

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

📆 May 14th, 2025 at 9:30 AM PDT, 12:30 PM EDT, 5:30 PM BST Navigating the AI Landscape 🤖 Explore the opportunities and challenges with integrating AI in healthcare and disease prevention. Register today to save your seat!

Clinical Trials

Fluoride Ban Could Create Cavities For 1 Of Every 3 U.S. Kids

Drugs.com

JUNE 2, 2025

MONDAY, June 2, 2025 Removing fluoride from the U.S. water supply could result in more than 25 million more decayed teeth in children and teenagers within five years, a new study warns.Thats the equivalent of a decayed tooth for 1 of every 3 kid.

CDD Vault Update (May 2025): New PDB Viewer, AI Similarity Searches, Registered IDs in AI Results, Inventory Unit Conversion, Visualize Batch Data, Nucleotide to Amino Acid Sequence Translation

Collaborative Drug

MAY 19, 2025

CDD Vault Update (May 2025): New PDB Viewer, AI Similarity Searches, Registered IDs in AI Results, Inventory Unit Conversion, Visualize Batch Data, Nucleotide to Amino Acid Sequence Translation

FDA Approves Polypill Widaplik for Hypertension

Drugs.com

JUNE 11, 2025

WEDNESDAY, June 11, 2025 -- The U.S. Food and Drug Administration has approved Widaplik (telmisartan, amlodipine, and indapamide) for the treatment of hypertension in adults.The combination pill is the first and only FDA-approved triple combination.

FDA Approval

FDA Approval FDA Treatment Drugs

FDA Upgrades Recall on 160,000+ Bottles of Thyroid Medication

Drugs.com

JULY 24, 2025

THURSDAY, July 24, 2025 — The U.S. Food and Drug Administration (FDA) has upgraded a recall of a commonly prescribed thyroid medication due to what it described as "subpotent" active ingredients. The recall of more than 160,000 bottles of.

FDA

FDA Drugs

Transforming Cancer Therapy: Insights from 2025 H1 FDA Approvals and Preclinical Drug Discovery

Crown Bioscience

JULY 17, 2025

Oncology drug approvals in H1 2025 In the first half of 2025, the FDA’s Center for Drug Evaluation and Research (CDER) approved a total of 16 novel drugs , with half of these drugs related to the treatment of cancer.

FDA Approval

FDA Approval Therapies FDA Drugs

FDA Limits COVID-19 Boosters to Seniors, Other High-Risk Groups

Drugs.com

MAY 21, 2025

WEDNESDAY May 21, 2025 The U.S. Food and Drug Administration (FDA) has decided that only seniors and people at high risk should get the latest COVID-19 booster shots this fall.The new framework, announced Tuesday, says adults 65 and older, and p.

FDA

FDA Drugs

June Q2 2025 - Product Update Webinar: AI+ and Curves

Collaborative Drug

JUNE 12, 2025

Explore new AI+ and curve fitting tools in CDD Vault for structure prediction, docking, and assay analysis. Now available with no setup required.

Production

FDA Approves Prefilled Syringe Presentation for Shingles Vaccine

Drugs.com

JULY 21, 2025

MONDAY, July 21, 2025 -- The U.S. Food and Drug Administration has approved a prefilled syringe presentation of Shingrix (zoster vaccine recombinant, adjuvanted) for the prevention of shingles (herpes zoster). The existing vaccine consists of two.

Vaccine

Vaccine FDA Approval FDA Drugs

New Antibody Shot, Enflonsia, Could Help Protect Babies From RSV

Drugs.com

JUNE 12, 2025

THURSDAY, June 12, 2025 — A newly approved shot could soon help protect babies from respiratory syncytial virus (RSV), the top cause of hospitalization in U.S. Food and Drug Administration (FDA) has approved a monoclonal.

Virus

Virus Hospitals FDA Drugs

Chemoselective Stabilized Triphenylphosphonium Probes for Capturing Reactive Carbonyl Species and Regenerating Covalent Inhibitors with Acrylamide Warheads in Cellulo

Covalent Modifiers

DECEMBER 28, 2024

Ai-Lin Chen, Zih-Jheng Lin, Hsiao-Yu Chang, and Tsung-Shing Andrew Wang Journal of the American Chemical Society , 2025 [link] Reactive carbonyl species (RCS) are important biomarkers of oxidative stress-related diseases because of their highly reactive electrophilic nature.

Disease

Disease Production

Biotech startup funding dried up in second quarter, HSBC finds

BioPharma Drive: Drug Pricing

JULY 17, 2025

Overall venture funding, as well as “first financing” rounds, fell significantly in the second quarter, erasing what had been a fast start to 2025, according to HSBC.

FDA to Review and Possibly Ban Fluoride Supplements for Kids

Drugs.com

MAY 14, 2025

WEDNESDAY, May 14, 2025 The U.S. Food and Drug Administration (FDA) plans to review and possibly remove prescription fluoride supplements for children from the market.The FDA announced Tuesday that it intends to conduct the review by Oct.

FDA

FDA Drugs

Altasciences At CPHI Americas 2025

Alta Sciences

JULY 3, 2025

Altasciences At CPHI Americas 2025 pmjackson Thu, 07/03/2025 - 13:41 In the ever-changing drug development world, staying agile is essential to enabling more informed decisions, faster. This blog was originally published in July 2025. Image Thumbnail_Blog_Lisa-v2.jpg Tags Manufacturing and Analytical Services Weight 14

Small Molecule

Small Molecule Drug Development Pharmaceuticals Science

Actithera draws new investors to radiopharma drug pitch

BioPharma Drive: Drug Pricing

JULY 9, 2025

Published July 9, 2025 Gwendolyn Wu Senior reporter post share post print email license Actinium is one of several radioisotopes favored by biotechnology companies developing drugs for cancer. billion in 2025, giving the industry a glimpse of radiopharmaceuticals’ sales potential. The drug earned Novartis more than $1.3

Drugs

Drugs Clinical Development Therapies Clinical Trials

Some Newer Antiseizure Meds Safer During Pregnancy

Drugs.com

JULY 17, 2025

THURSDAY, July 17, 2025 — Some newer antiseizure medications appear to be safer for pregnant women to take without risk of birth defects, a new study says. Second-generation antiseizure drugs like levetiracetam, oxcarbazepine, gabapentin and.

Drugs

Collaborative Drug Discovery and deepmirror Announce Collaboration for Humanitarian and Commercial Drug Discovery

Collaborative Drug

JULY 8, 2025

July 8, 2025. BURLINGAME, Calif.

Drugs

Drugs Pharmaceuticals

Insulin Nasal Spray Reaches Alzheimer's Targets, Brain Scans Show

Drugs.com

JULY 24, 2025

THURSDAY, July 24, 2025 — Insulin delivered by nasal spray might be a potential treatment for Alzheimer’s disease, a new study says. An insulin nasal spray effectively reached key memory regions in the brains of a small group of older.

Treatment

Treatment Disease

Sports, Exercise Protects Mental Health Of Growing Kids

Drugs.com

MAY 14, 2025

WEDNESDAY, May 14, 2025 Exercise and sports appear to help kids avoid mental health problems as they grow into young adults, a new study says.Young children who participated in sports teams and physical education classes were less likely to d.

Recap Of The Collaborative Drug Discovery's Inaugural Canadian User Group Meeting

Collaborative Drug

JULY 17, 2025

The 2025 CDD User Group Meeting (UGM) Canada brought together researchers, industry experts, and thought leaders to discuss the latest advancements in drug discovery, data management, and collaborative research.

Drugs

Drugs Research

Too Much Cinnamon May Interfere With Some Medications, Study Shows

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 Consuming too much cinnamon might affect how your body absorbs some medications, new research shows.The study published in the June issue of the journal Food Chemistry: Molecular Sciences looked at how cinnamon and its key.

Science

Science Research

Eli Lilly to Buy Gene Therapy Firm Verve in $1 Billion Deal to Develop Heart Drug

Drugs.com

JUNE 18, 2025

WEDNESDAY, June 18, 2025 — Drugmaker Eli Lilly plans to buy Verve Therapeutics, a gene-editing startup, for about $1 billion upfront. The deal gives Lilly a potential new treatment for heart disease, The Wall Street Journal reported.

Therapies

Therapies Treatment Disease Drugs

Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads

Covalent Modifiers

MAY 7, 2025

Xinyuan Wu, Jiayi Pan, Rufeng Fan, Yiwei Zhang, Chao Wang, Guoliang Wang, Jiaxiang Liu, Mengqing Cui, Jinfeng Yue, Rui Jin, Zhiqiang Duan, Mingyue Zheng, Lianghe Mei, Lu Zhou, Minjia Tan, Jing Ai, and Xiaojie Lu Journal of the American Chemical Society 2025 147 (18), 15469-15481 DOI: 10.1021/jacs.5c01712

DNA

DNA Small Molecule Therapies Drugs

Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders

Covalent Modifiers

JUNE 25, 2025

2025 , 147 , 25 , 21512–21525 [link] Targeted protein degradation (TPD) has emerged as a promising therapeutic strategy for treating various diseases. Xiaoqiang He, Shihan Zeng, Yalei Wen, Tao Yang, Chaoming Huang, Yifang Li, Zhang Zhang, Ke Ding, Tongzheng Liu, Yi Tan, and Zhengqiu Li J.

Targeted Protein Degradation

Targeted Protein Degradation Small Molecule Disease

Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Covalent Modifiers

FEBRUARY 10, 2025

DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes.

Biophysical Assays

Biophysical Assays Small Molecule Engineering Regulations

Discovery and Optimization of a Covalent AKR1C3 Inhibitor

Covalent Modifiers

APRIL 25, 2025

Seal, James Veccia, and Ku-Lung Hsu Journal of Medicinal Chemistry 2025 [link] Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-dependent cancers. Justin Grams, Wesley J. Wolfe, Robert J.

Cell Biology

Long-Lasting HIV Prevention Shot Headed Toward Approval

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — A new injection to prevent HIV is expected to be approved by the U.S. Food and Drug Administration (FDA) later this month. If approved, the shot — lenacapavir — would be given twice a year and could be a big.

FDA

FDA Drugs

Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis

Covalent Modifiers

MAY 23, 2025

Danyang Hu, Hairong Zeng, Wenxuan Li, Ya Zhang, Xiaoqian Chi, Xiaoyu Liu, Haijing Zhang, Guangbo Ge, Xiaozhen Jiao, and Ping Xie Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.5c00563 We previously reported that bysspectin A and its derivative LC-20W were potent reversible hCES2A inhibitors.

Drugs

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Collaborative Drug

MARCH 21, 2025

Our recent Q1 2025 scientific webinar brought together industry veterans Dr. Chris Waller and Dr. Dimitris Agrafiotis to discuss the current state and future directions of drug discovery informatics in large pharmaceutical organizations led by CDD's Founder and CEO, Dr.

Drugs

Drugs Pharmaceuticals

Advancing Covalent Ligand and Drug Discovery beyond Cysteine

Covalent Modifiers

JUNE 5, 2025

Justin Grams, and Ku-Lung Hsu Chemical Reviews 2025 DOI: 10.1021/acs.chemrev.5c00001 Gibae Kim, R. 5c00001 Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional drug design.

Drugs

GLP-1 Drugs Appear To Lower Cancer Risk

Drugs.com

MAY 19, 2025

MONDAY, May 19, 2025 Cutting-edge GLP-1 weight-loss drugs appear to help lower cancer risk even beyond the benefits from dropping excess pounds, a new study says.First-generation GLP-1 drugs like liraglutide (Saxenda) and exenatide (Byetta) were a.

Drugs

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

Covalent Modifiers

APRIL 20, 2025

Genhui Xiao, Yumeng Cui, Liangliang Zhou, Chuya Niu, Bing Wang, Jinglan Wang, Shaoyang Zhou, Miaomiao Pan, Chi Kin Chan, Yan Xia, Lan Xu, Yu Lu, Shawn Chen mLife , 2025 DOI: [link] The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens.

Small Molecule

Small Molecule Drugs Research

Florida-Grown Cucumbers Behind Salmonella Outbreak, CDC Warns

Drugs.com

MAY 21, 2025

WEDNESDAY, May 21, 2025 Health officials are investigating a salmonella outbreak tied to cucumbers grown in Florida. At least 26 people across 15 states have gotten sick, and nine people have been hospitalized, the U.S. Food and Drug A.

Hospitals

Hospitals Drugs

More Florida Teens Strapping Up, Study Says

Drugs.com

JULY 8, 2025

TUESDAY, July 8, 2025 — More Florida teens are roaming the streets packing heat, a new study says.Handgun carrying among Florida middle and high school students increased by 65% between 2002 and 2022, researchers reported July 7 in the journal P.

Research

More U.S. Teens Getting Weight-Loss Surgery

Drugs.com

MAY 14, 2025

WEDNESDAY, May 14, 2025 More U.S. teenagers are getting weight-loss surgery, despite the discovery of new drugs like Ozempic/Wegovy that help people drop pounds surgery-free, a new study says.Weight loss surgeries for teens increased 15% between 2.

Drugs

AI Can Catch Hard-To-Detect Breast Cancers In Mammograms

Drugs.com

MAY 14, 2025

WEDNESDAY, May 14, 2025 -- Artificial intelligence (AI) can help prevent breast cancers that develop between routine mammograms, by catching ones that trained radiologists would overlook, a new study says.Incorporating AI into mammography could.

Weight Gain, Delayed Motherhood Linked To Breast Cancer Risk

Drugs.com

MAY 14, 2025

WEDNESDAY, May 14, 2025 Significant weight gain paired with delayed or foregone motherhood nearly triples a young womans risk of later breast cancer, a new study says.Women were 2.7 times more likely to develop breast cancer if they:Had a more th.

Methods for Kinetic Evaluation of Reversible Covalent Inhibitors from Time-Dependent IC50 Data

Covalent Modifiers

MARCH 24, 2025

2025 DOI: 10.1039/D5MD00050E Potent reversible covalent inhibitors are often slow in establishing their covalent modification equilibrium, resulting in time-dependent inhibition. Mader and J. Keillor, RSC Med.

Drugs

Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors

Covalent Modifiers

APRIL 25, 2025

Cravatt Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c01944 Cravatt, Timothy B. Ware, Alex Reed, Molhm Nassir, Tamara El-Hayek Ewing, Bruno Melillo, J. Fernando Bazan, Phil S. Baran, and Benjamin F.

Merck Names Neoclease Winner of 2025 Biotech Grant

The Pharma Data

JUNE 18, 2025

This year’s North American announcement will be followed by regional grant awards in Asia-Pacific (October 2025) and Europe, the Middle East, and Africa (EMEA) (November 2025), reflecting Merck’s strategic commitment to fostering innovation in every major biotech market.

Therapies

Therapies Science Disease Treatment

How AI will reshape pharma by 2025

CDD Vault Update (July 2025): Custom Axis Scaling, AUC Fold Change, Copy Reactions and Stoichiometry Tables, and Sample Tracking Improvements for the ELN

Trending Sources

CDD Vault Update (July #2 2025) Search Inventory by Molecule & Batch Fields, Protocol Plate Locations, Stoichiometry Table Debiting, Synonym Links in ELN, Chemical Properties in Structure Editor

Ubrogepant (Ubrelvy) Effective Against Early Migraine Symptoms

Bridging Innovation & Patient Care: The Growing Role of AI

Fluoride Ban Could Create Cavities For 1 Of Every 3 U.S. Kids

CDD Vault Update (May 2025): New PDB Viewer, AI Similarity Searches, Registered IDs in AI Results, Inventory Unit Conversion, Visualize Batch Data, Nucleotide to Amino Acid Sequence Translation

FDA Approves Polypill Widaplik for Hypertension

FDA Upgrades Recall on 160,000+ Bottles of Thyroid Medication

Transforming Cancer Therapy: Insights from 2025 H1 FDA Approvals and Preclinical Drug Discovery

FDA Limits COVID-19 Boosters to Seniors, Other High-Risk Groups

June Q2 2025 - Product Update Webinar: AI+ and Curves

FDA Approves Prefilled Syringe Presentation for Shingles Vaccine

New Antibody Shot, Enflonsia, Could Help Protect Babies From RSV

Chemoselective Stabilized Triphenylphosphonium Probes for Capturing Reactive Carbonyl Species and Regenerating Covalent Inhibitors with Acrylamide Warheads in Cellulo

Biotech startup funding dried up in second quarter, HSBC finds

FDA to Review and Possibly Ban Fluoride Supplements for Kids

Altasciences At CPHI Americas 2025

Actithera draws new investors to radiopharma drug pitch

Some Newer Antiseizure Meds Safer During Pregnancy

Collaborative Drug Discovery and deepmirror Announce Collaboration for Humanitarian and Commercial Drug Discovery

Insulin Nasal Spray Reaches Alzheimer's Targets, Brain Scans Show

Sports, Exercise Protects Mental Health Of Growing Kids

Recap Of The Collaborative Drug Discovery's Inaugural Canadian User Group Meeting

Too Much Cinnamon May Interfere With Some Medications, Study Shows

Eli Lilly to Buy Gene Therapy Firm Verve in $1 Billion Deal to Develop Heart Drug

Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads

Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders

Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Discovery and Optimization of a Covalent AKR1C3 Inhibitor

Long-Lasting HIV Prevention Shot Headed Toward Approval

Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Advancing Covalent Ligand and Drug Discovery beyond Cysteine

GLP-1 Drugs Appear To Lower Cancer Risk

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

Florida-Grown Cucumbers Behind Salmonella Outbreak, CDC Warns

More Florida Teens Strapping Up, Study Says

More U.S. Teens Getting Weight-Loss Surgery

AI Can Catch Hard-To-Detect Breast Cancers In Mammograms

Weight Gain, Delayed Motherhood Linked To Breast Cancer Risk

Methods for Kinetic Evaluation of Reversible Covalent Inhibitors from Time-Dependent IC50 Data

Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors

Merck Names Neoclease Winner of 2025 Biotech Grant

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