Metabolite Tales Blog

OCTOBER 5, 2023

Trapping agents are described for reactive metabolites that could ordinarily be overlooked due to quenching with endogenous small molecules and protein nucleophiles. Journal of Medicinal Chemistry Article ASAP. Christopher, Robert S. Foti, Chungang Gu, S. Cyrus Khojasteh, Joyce Liu, Shuguang Ma, Bin Ma, R.

Small Molecule

Drug Target Review

JULY 18, 2023

This article is the second part of my interview with Olivia Cavlan, Chief Corporate Development and Strategy Officer at Alchemab Therapeutics Ltd, this time exploring the AI applications in personalised medicine, and the evolving landscape of drug development. This means that we are not doing something right.

Drug Development

LifeSciVC

MARCH 1, 2023

Such is the story of targeting casitas B-lineage lymphoma-B (CBL-B) that was highlighted in a recent scientific review article published in the Journal for ImmunoTherapy of Cancer. Even good ideas are met with healthy skepticism for the practical and technical limitations of being able to effectively test a hypothesis.

Small Molecule

KIF1A

MAY 6, 2023

In this week’s article, researchers collected high resolution recordings of the kinesin-1 motor protein as it walked along the microtubule. To do so, they tagged a single head of kinesin with a fluorophore, a small molecule that lights up when excited by (i.e. hit by) the lasers in microscopes.

Small Molecule

Alta Sciences

APRIL 17, 2024

In this blog article, we review some of these areas of investigation where Altasciences has robust expertise and solution offerings. According to a 2022 article published in Molecular Psychiatry, treatment resistance affects 20 to 60% of patients with psychiatric disorders. Asia, and Europe.

Drug Development

Vial

FEBRUARY 19, 2024

We can link small molecule drugs to a payload that would enter in the cell and kill it. We have the capability of different types of targets, whether small molecules or antibodies. Also, payloads that are permeable payloads and specifically microtubule inhibitors or DNA alkylators or chemo.

Small Molecule

Agency IQ

JULY 26, 2024

in equipment) for products that are more complex or aren’t as well-characterized, such as antibody drug conjugates or recombinant DNA products, will be considered higher risk than they would if the change was made to the production of standard, small molecule products. Any CMC changes (e.g.,

Biosimilars

Agency IQ

AUGUST 11, 2023

In a study of more than 12,000 small molecule drugs , researchers found 40.4% This latter category is “not predicted to be metabolically activated via an α-hydroxylation pathway,” or would not be predicted to react with DNA. of the APIs analyzed were nitrosamine precursors.

FDA

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression.

DNA

Agency IQ

APRIL 19, 2024

Note: Both analyses focused only on studies of small molecules, antibodies and biologics; studies of CAR T therapies were not included. The i2TEAMM meta-analysis had a broader scope, including previously untreated, newly diagnosed patients (transplant eligible or ineligible) as well as patients with RRMM.

FDA

PLOS: DNA Science

JUNE 22, 2023

A “DNA damage checkpoint” rests the cell cycle while special proteins repair damaged DNA. The candidate drug, vorasidenib, is a small molecule that inhibits survivin. Here’s an article from 2002. The post How Targeted Cancer Drugs Disrupt the Cell Cycle appeared first on DNA Science.

Drugs

Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

Vaccine

Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

Vaccine

KIF1A

AUGUST 20, 2024

Susannah’s ASO Treatment Regimen A brief note: Throughout this post I will be citing the original article; unless otherwise noted, quotes are sourced from Ziegler et al. The effects of an ASO administered to the eye have yet to be determined, and we are also investigating small-molecule therapies to treat this high-priority symptom.

Science

The Pharma Data

DECEMBER 21, 2020

With seven new medicines launched between 2014 and 2020, and a broad pipeline of small molecules and biologics in development, the Company is committed to advance oncology as a key growth driver for AstraZeneca focused on lung, ovarian, breast and blood cancers. Related Articles: Tagrisso (osimertinib) FDA Approval History.

Treatment

Drug Target Review

DECEMBER 13, 2024

Innovations in payload substances, such as topoisomerase inhibitors (topo-1i), and next-generation DNA- damaging agents to replace older, more toxic agents. Additionally, newer-generation linkers enable more specific and stable payload attachment, potentially improving therapeutic indices and safety.

Therapies

Codon

DECEMBER 12, 2024

” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” For the article in Science , more than 30 scientists from ten countries are calling on the broader community to confront the risks of mirrored life. ” But what, exactly, is a mirrored organism?

RNA

Codon

APRIL 16, 2023

Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. Perhaps there is now a way to use DNA to extract metals: You could fuse the DNA strands to an antibody, coat them onto electronics, and then use a column to isolate the DNA:metal compounds? coli DNA using a Retro-Cascorder.

Engineering

BioPharma Drive: Drug Pricing

JUNE 12, 2025

Deep Dive Library Events Press Releases Topics Sign up Search Sign up Search Pharma Biotech FDA Clinical Trials Deals Drug Pricing Gene Therapy An article from Pharma’s wins and losses in the budget bill Key pharma reforms are up in the air as Republicans battle over their mammoth legislation that includes significant healthcare spending cuts.

Small Molecule

Codon

FEBRUARY 16, 2025

This article is best experienced on our website. Building a Circuit Much like electronic circuits, which use wires and transistors to create or process signals, a synthetic gene circuit is a network of biological parts — DNA, RNA, and proteins — that process inputs and generate outputs. 3 Subscribe to Asimov Press.

DNA

Drug Target Review

DECEMBER 11, 2024

While LLMs are most commonly associated with consumer tools like ChatGPT, they can be trained on any text-based dataset, including DNA and protein sequences. Generative AI algorithms, known as large language models (LLMs), are useful for predicting and manipulating interactions between antibodies, TCRs and their targets.

Immune Response