Drug Target Review

JULY 7, 2025

3-5 These layers of regulation, while essential for animal welfare, make NHP-based studies complex, expensive and time-consuming. However, the last decade has seen a gradual reduction in their use, driven by tightening animal welfare regulations and scientific advances. Guide for the Care and Use of Laboratory Animals.

Drug Research 52

Drug Research Research Animal Testing Drugs 52

Codon

NOVEMBER 1, 2024

Today, we are largely unable to predict the outcomes of even “simple” biological questions, such as, “If I take this gene from an Arabidopsis plant, and insert it into Escherichia coli , will the cell express the gene and make functional protein?” ” Nobody really knows without trying it out in the laboratory.

DNA 132

DNA RNA Molecular Biology Laboratories 132

Drug Target Review

JULY 13, 2023

The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

Drug Target Review

SEPTEMBER 19, 2023

This major shift to the orthodox tradition of using animal experiments in drug testing dates back the Aristotle’s time and cemented 80 years ago with initial federal mandate of drug safety regulation of 1938. From 3D cell culture to organs-on-chips. Trends in Cell Biology. 2010;328(5986):1662-8. 2011;21(12):745-54.

Animal Testing 98

Animal Testing Clinical Trials Pharmaceutical Companies FDA 98

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

That includes those involved in regulating our appetites and our moods, via a class of G proteins known as inhibitory G proteins (G i ). They share a common architecture and bind a relatively limited number of intracellular signaling proteins called G proteins. 2011 Jul 19;477(7366):549-55.

Laboratories 52

Laboratories Research Drugs Regulations 52

Broad Institute

JULY 28, 2023

Our pilot study will span: 1) high-resolution EM (electron microscopy) of synaptic excitatory-inhibitory (E-I) balance and nearby glial cells; 2) functional electrophysiological signatures of altered E-I balance by sex in ACC brain slices; 3) molecular correlates of these impairments that can be targeted for recovery of function.

Medical Schools 52

Medical Schools Hospitals Regulations Research 52

Codon

APRIL 2, 2023

A giant dataset about the rat brain, and how neurons connect to each other, was collected and pooled together from 20 different research laboratories. An open-source FACS automation system for high-throughput cell biology. Cell Systems. “Human cells hacked to act like squid skin cells could unlock key to camouflage.”

DNA 52

DNA RNA Engineering Licensing 52