Remove DNA Remove Government Remove Immune Response
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Scientists engineer CRISPR enzymes that evade the immune system

Broad Institute

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The team identified protein sequences on each nuclease that trigger the immune system and used computational modeling to design new versions that evade immune recognition.

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The immune system’s role in lung cancer risk

Drug Target Review

HLA are the critical molecules that our immune systems use to present peptides to T cells and facilitate recognition and killing in immune responses to pathogens. HLA-II presents peptides to CD4 T cells thought to be important for indirectly helping immune responses and facilitating antibody production.

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UK Pharma Company Scancell Selects COVID-19 Vaccine for Clinical Trials | 2020-12-21

The Pharma Data

SN14 works by targeting the coronavirus’ nucleocapsid and spike proteins to prevent viral replication using the company’s ImmunoBody DNA vaccine technology. The company, along with partners University of Nottingham and Trent University, received a British government grant to support the study. . Source link.

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INOVIO Announces Publication of Phase 1 Data from its COVID-19 DNA Vaccine Candidate, INO-4800 in The Lancet’s EClinicalMedicine

The Pharma Data

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

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Mechanisms, Challenges, and Future Use Cases of Epigenetic Drugs

DrugBank

Epigenetics , the study of changes in gene activity that occur without altering the DNA sequence, has revolutionized our understanding of gene expression regulation. DNA methylation involves adding methyl groups to cytosine residues in CpG dinucleotides , a process catalyzed by DNA methyltransferases (DNMT).

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Women in Stem with Dr Christine Schuberth-Wagner

Drug Target Review

Everything started in school with an experiment on isolating DNA from bananas. Making a little tangle of DNA visible to the eye and understanding that this is the basis of complex organisms, which might be altered in disease, was the defining moment for my future path in life sciences.

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Biological robots: a new therapeutic tool

Drug Target Review

This discovery begins to solve a wider question posed by the lab: what governs how cells assemble and work together in the body, and can the cells be taken out of their natural context and recombined into different ‘body plans’ to do other functions by design?