DNA Protein Expression Therapies 
LifeSciVC
JUNE 12, 2025
Josh’s work at the Marine Biological Laboratory unlocked the potential of utilizing an endogenous protein to make a single alphabet change on RNA (RNA editing), a process that was precise, reversible and had druglike characteristics. This concept of effecting a protein change.
Codon
APRIL 14, 2025
DNA sequencing and synthesis costs have dropped precipitously, in part, because maintaining Carlson curves became a rallying point for the field. One such opportunity, for example, is in protein expression. For starters, we not only need faster, cheaper options (supply) but also people excited to use them (demand).
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Conversations in Drug Development Trends
APRIL 7, 2025
This approach improves treatment outcomes over traditional broad-spectrum therapies, which are prone to more side effects and adverse events. Carefully crafted enrichment strategies optimize recruitment and enrollment, ensuring that the included participants will likely respond to the therapy.
DrugBank
JULY 24, 2024
For example, PROTACs targeting STAT3, a protein crucial for tumor growth, have shown promise where conventional therapies have failed. Similarly, PROTACs can target and degrade overexpressed proteins, offering a way to overcome drug resistance, a common issue in cancer treatment.
The Pharma Data
MARCH 30, 2021
Broad expression of FAP demonstrated in tumors or in tumor stroma across many solid tumors 1 ,2 ,3. Novartis Oncology continues to reimagine cancer care through development of robust radioligand therapy portfolio. We continue to invest in radioligand therapy as one of the four unique platforms of Novartis Oncology.
Conversations in Drug Development Trends
AUGUST 14, 2024
Hematological cancer cells can also develop resistance to therapies over time, reducing treatment effectiveness. Fortunately, personalized treatment plans help circumvent therapy resistance while optimizing response rate and improving quality of life.
Alta Sciences
APRIL 17, 2024
Psychedelics Psychedelic therapy (or psychedelic-assisted therapy) refers to the use of psychedelic drugs, such as psilocybin, MDMA, LSD, ketamine, and ayahuasca, to treat mental disorders, especially those that have no effective treatments available or are treatment resistant.
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