Drugs - Drug Discovery Digest

Bristol Myers allies with BioNTech on bispecific cancer drug

BioPharma Drive: Drug Pricing

JUNE 2, 2025

billion to co-develop a BioNTech drug that targets the proteins PD1 and VEGF, following Merck, and Pfizer into what’s become a competitive development race. The oncology giant will pay $1.5

Drugs

GLP-1 Drugs Appear To Lower Cancer Risk

Drugs.com

MAY 19, 2025

MONDAY, May 19, 2025 Cutting-edge GLP-1 weight-loss drugs appear to help lower cancer risk even beyond the benefits from dropping excess pounds, a new study says.First-generation GLP-1 drugs like liraglutide (Saxenda) and exenatide (Byetta) were a.

Drugs

Brain training game offers new hope for drug-free pain management

Science Daily: Pharmacology News

JUNE 2, 2025

A trial of an interactive game that trains people to alter their brain waves has shown promise as a treatment for nerve pain -- offering hope for a new generation of drug-free treatments.

Drugs

Drugs Treatment Trials

Diabetes Drug, Dapagliflozin, Effective For Fatty Liver Disease

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — A repurposed diabetes drug can be an effective tool against fatty liver disease, a new clinical trial has found. Dapagliflozin helped people reduce fat levels in their liver and avoid liver scarring that comes with the.

Disease

Disease Clinical Trials Drugs Trials

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Combo Drug Treatment More Effective For Kidney Disease in Type 2 Diabetics

Drugs.com

JUNE 9, 2025

MONDAY, June 9, 2025 — Prompt treatment with a drug combo can effectively manage chronic kidney disease in people with type 2 diabetes, a new clinical trial shows. Patients prescribed the combination of finerenone and empagliflozin.

Treatment

Treatment Disease Clinical Trials Drugs

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Collaborative Drug

MARCH 21, 2025

Our recent Q1 2025 scientific webinar brought together industry veterans Dr. Chris Waller and Dr. Dimitris Agrafiotis to discuss the current state and future directions of drug discovery informatics in large pharmaceutical organizations led by CDD's Founder and CEO, Dr. Barry Bunin.

Drugs

Drugs Pharmaceuticals

FDA to speed reviews for drugs supporting ‘national interests’

BioPharma Drive: Drug Pricing

JUNE 18, 2025

A new pilot program announced by FDA Commissioner Martin Makary would award vouchers that could cut drug reviews to one or two months — but only for products that meet a special criteria.

FDA

FDA Drugs Production

Alzheimer’s Drug, Leqembi, Can Be Safely Administered In Memory Clinics, Study Says

Drugs.com

MAY 15, 2025

THURSDAY, May 15, 2025 — The 2023 approval of the first drug shown to slow the progression of Alzheimer’s disease came with no small amount of concern from skeptics. Lecanemab (Leqembi) modestly slows Alzheimer’s by helping the.

Drugs

Drugs Disease

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes.

Clinical Trials

AstraZeneca drug could help keep a common breast cancer at bay

BioPharma Drive: Drug Pricing

JUNE 1, 2025

Data presented at ASCO show that swapping in the oral drug camizestrant for an older therapy helped sustain the benefit of initial treatment, potentially opening a novel step in patient care.

Drugs

Drugs Therapies Treatment

Agility with Complex Data Sets – Integration of Predicted and Empirical Data for Drug Discovery

Collaborative Drug

DECEMBER 6, 2024

We recently hosted an insightful webinar featuring the team from Congruence Therapeutics , who shared how they're using CDD Vault alongside their proprietary systems to manage complex drug discovery data.

Computational Chemistry

Computational Chemistry Drugs

Real-World Results For GLP-1 Drugs Underwhelm, Study Says

Drugs.com

JUNE 11, 2025

WEDNESDAY, June 11, 2025 — Real-world results for blockbuster weight-loss meds like Ozempic, Wegovy and Zepbound aren’t as impressive as those promised by the drugs’ clinical trials, a new study says. People taking such GLP-1.

Clinical Trials

Clinical Trials Drugs Trials

Diabetes Drug Effective For Fatty Liver Disease

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — A repurposed diabetes drug can be an effective tool against fatty liver disease, a new clinical trial has found.Dapagliflozin helped people reduce fat levels in their liver and avoid liver scarring that comes with the c.

Disease

Disease Clinical Trials Drugs Trials

Otsuka tops Vera with kidney drug data; Regenxbio sinks on Duchenne update

BioPharma Drive: Drug Pricing

JUNE 6, 2025

Elsewhere, investors scrutinized Regenxbio’s Duchenne data and a brain drug study failed. Late-stage results Otsuka presented in IgA nephropathy triggered a sell-off in Vera shares.

Drugs

Texas Invests $50M in Psychedelic Drug Research into Ibogaine to Treat Addiction

Drugs.com

JUNE 16, 2025

MONDAY, June 16, 2025 — Texas has moved to fund research into ibogaine, a psychedelic drug that may help treat addiction, depression, and brain injuries. Greg Abbott signed a bill last week approving $50 million in state funds for.

Drug Research

Drug Research Research Drugs

Vera drug scores in closely watched study in rare kidney disease

BioPharma Drive: Drug Pricing

JUNE 2, 2025

Phase 3 results revealed Monday led shares to surge and should yield an approval application in IgA nephropathy, a competitive corner of drug research, later this year.

Disease

Disease Drugs Drug Research Research

New Drug Could Quell Uncontrolled High Blood Pressure

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 An experimental drug might help people with uncontrolled high blood pressure, according to early clinical trial results.People taking lorundrostat experienced twice the decline in their systolic blood pressure than people t.

Clinical Trials

Clinical Trials Drugs Trials

FDA Plans to Use AI to Speed Up Drug and Food Safety Reviews

Drugs.com

JUNE 11, 2025

Food and Drug Administration (FDA) says it plans to use artificial intelligence (AI) to help speed the approval of new drugs and medical devices. WEDNESDAY, June 11, 2025 — The U.S. That's one of several priorities federal officials detailed.

FDA

FDA Drugs

Advancing Covalent Ligand and Drug Discovery beyond Cysteine

Covalent Modifiers

JUNE 5, 2025

5c00001 Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional drug design. Justin Grams, and Ku-Lung Hsu Chemical Reviews 2025 DOI: 10.1021/acs.chemrev.5c00001

Drugs

Abeona sells speedy drug review voucher for $155M

BioPharma Drive: Drug Pricing

MAY 12, 2025

The biotech has quickly turned a cell therapy approval into one of the more lucrative recent sales for a priority review voucher, which companies can use to fast track drug reviews.

Drugs

Drugs Therapies

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide

Chemical Biology and Drug Design

JANUARY 20, 2025

ABSTRACT Drug targeting strategies, such as peptidedrug conjugates (PDCs), have arisen to combat the issue of off-target toxicity that is commonly associated with chemotherapeutic small molecule drugs. The PDCs crossed membranes and cleavable PDCs killed melanoma cells with nanomolar potency.

Small Molecule

Small Molecule Drugs International Therapies

FDA approves twice-yearly shot of Gilead drug for HIV prevention

BioPharma Drive: Drug Pricing

JUNE 18, 2025

The clearance ushers in a closely-watched launch for Gilead, which aims to show a long-acting injection can upend a market dominated by oral medicines.

FDA Approval

FDA Approval FDA Marketing Drugs

Targeted Covalent Modification Strategies for Drugging the Undruggable Targets

Covalent Modifiers

JANUARY 9, 2025

4c00745 The term undruggable refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic properties. Thus, investigating methods to achieve such drugging is an important challenge in medicinal chemistry.

Drugs

Drugs Therapies Treatment Disease

Daiichi Sankyo struck gold with ‘ADC’ cancer drugs. Its new CEO has to figure out what’s next.

BioPharma Drive: Drug Pricing

JUNE 4, 2025

Enhertu, Datroway and other antibody-drug conjugates developed by Daiichi Sankyo have made the company a leader in a competitive field. Hiroyuki Okuzawa is working to keep it that way.

Drugs

Insmed surges on lung drug data; Recursion cuts staff

BioPharma Drive: Drug Pricing

JUNE 11, 2025

Insmed shares rocketed on results for a pulmonary arterial hypertension drug that exceeded Wall Street expectations. Elsewhere, Recursion is laying off 20% of its workforce and Gilead halted several HIV studies.

Drugs

PTC stock slides on new data for Huntington’s drug

BioPharma Drive: Drug Pricing

MAY 5, 2025

While updated study results confirmed the drug lowers a target protein, the therapy's effect on clinical outcomes was less clear-cut.

Drugs

Drugs Therapies

Genetics is a missing link in kidney disease drug development

BioPharma Drive: Drug Pricing

JUNE 2, 2025

Genetic research is driving progress in kidney disease drug discovery.

Disease

Disease Drug Development Drugs Research

Reproductive health startup raises $65M for infertility drugs

BioPharma Drive: Drug Pricing

MAY 21, 2025

Founded in 2021, ReproNovo has licensed rights to two drugs from Mereo BioPharma and ObsEva that it thinks could address fertility issues in men and women.

Licensing

Licensing Licensing Drugs

Drug Effective Against Early Migraine Symptoms

Drugs.com

MAY 14, 2025

WEDNESDAY, May 14, 2025 -- Migraines dont just cause headaches.These attacks often are accompanied by symptoms like light and sound sensitivity, nausea, neck pain and dizziness.Whats more, those non-headache symptoms tend to crop up before a ful.

Drugs

Experimental Drug Lorundrostat Could Quell Uncontrolled High Blood Pressure

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 — An experimental drug might help people with uncontrolled high blood pressure, according to early clinical trial results. People taking lorundrostat experienced twice the decline in their systolic blood pressure than.

Clinical Trials

Clinical Trials Drugs Trials

Top Scientific Data Platforms for AI-Driven Drug Discovery: What to Look For

Collaborative Drug

JUNE 11, 2025

Compare top scientific data platforms for AI-driven drug discovery. Evaluate CDD Vault, Dotmatics, Benchling & more for chemistry and biologics workflows.

Drugs

GSK to buy liver disease drug for $1.2B

BioPharma Drive: Drug Pricing

MAY 14, 2025

The new acquisition from Boston Pharmaceuticals adds to a wave of dealmaking undertaken by GSK to build its liver disease franchise.

Disease

Disease Pharmaceuticals Drugs

After rejections, AbbVie secures approval for Parkinson’s drug

BioPharma Drive: Drug Pricing

OCTOBER 17, 2024

Vyalev’s clearance is the second victory for AbbVie in Parkinson’s this year, following an April readout for a drug acquired through its Cerevel buyout.

Drugs

CDD Vault Curves vs. GraphPad Prism: Which Tool is Best for Early-Stage Drug Discovery Data Analysis?

Collaborative Drug

JUNE 16, 2025

Compare CDD Vault Curves vs GraphPad Prism for drug discovery data analysis. See which tool best fits your workflow for curve fitting and collaboration.

Drugs

Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis

Covalent Modifiers

MAY 23, 2025

Collectively, a novel serine-targeting covalent inhibitor against hCES2A was developed, offering a promising candidate for treating drug-induced diarrhea and ulcerative colitis. In vivo tests showed that 9d significantly alleviates irinotecan-induced diarrhea and dextran sulfate sodium-induced colitis.

Drugs

Summit lung cancer drug shows ‘striking’ benefit over Keytruda

BioPharma Drive: Drug Pricing

SEPTEMBER 8, 2024

Study results provide much-anticipated details to Summit’s claim earlier this year that its drug “decisively beat” Merck’s dominant immunotherapy.

Drugs

Use of new approach methodology for hepatic safety assessment of covalent inhibitor drug candidates

Covalent Modifiers

MAY 28, 2025

However, the inherent targeted covalent inhibitor (TCI) adverse off-target reactivity risk requires a mitigation strategy early during drug discovery. Drug induced liver injury was assessed in primary human hepatocyte spheroids. The mitigation strategy was applied to compound 35, a potent irreversible inhibitor to KRASG12C.

Drugs

Drugs Treatment Research Marketing

Analyzing Oxygen Atom Distribution in FDA‐Approved Drugs to Enhance Drug Discovery Strategies

Chemical Biology and Drug Design

FEBRUARY 6, 2025

Analysis of prevalence of ring, nonring, sp 3 -, and sp 2 -hybridized oxygen in approved drugs. This work presents a comprehensive analysis of oxygen atoms in approved drugs, aiming to streamline drug design and discovery efforts. In approved drugs, majority of oxygen atoms are present within 4 from the COM of the molecule.

FDA Approval

FDA Approval FDA Small Molecule Pharmacokinetics

FDA clears CSL’s swelling disease drug; Regeneron loses 23andMe auction

BioPharma Drive: Drug Pricing

JUNE 17, 2025

The agency cleared CSL’s hereditary angioedema drug days after “resource constraints” delayed a rival medicine. Elsewhere, Intellia revealed new data and Lilly beefed up an online service offering access to Zepbound.

Disease

Disease FDA Drugs

GLP-1 Drugs Improve Outlook For Kidney Transplants

Drugs.com

MARCH 6, 2025

THURSDAY, March 6, 2025 -- GLP-1 drugs like Ozempic can help kidney transplant patients avoid organ failure and live longer, a new study suggests.The drugs help manage patients type 2 diabetes and promote weight loss, both of which improve the c.

Drugs

Stroke rehabilitation drug repairs brain damage

Science Daily: Pharmacology News

MARCH 18, 2025

A new study has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice, following from human studies.

Drugs

Drugs Research

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

JANUARY 30, 2025

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

FDA Approval

FDA Approval Doctors Research FDA

A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

BioPharma Drive: Drug Pricing

SEPTEMBER 4, 2024

But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes. Over the past 10 years, PD1-blocking medicines have transformed cancer care.

Pharmaceutical Companies

Pharmaceutical Companies Drugs Pharmaceuticals

Bristol Myers allies with BioNTech on bispecific cancer drug

GLP-1 Drugs Appear To Lower Cancer Risk

Trending Sources

Brain training game offers new hope for drug-free pain management

Diabetes Drug, Dapagliflozin, Effective For Fatty Liver Disease

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Combo Drug Treatment More Effective For Kidney Disease in Type 2 Diabetics

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

FDA to speed reviews for drugs supporting ‘national interests’

Alzheimer’s Drug, Leqembi, Can Be Safely Administered In Memory Clinics, Study Says

Bridging Innovation & Patient Care: The Growing Role of AI

AstraZeneca drug could help keep a common breast cancer at bay

Agility with Complex Data Sets – Integration of Predicted and Empirical Data for Drug Discovery

Real-World Results For GLP-1 Drugs Underwhelm, Study Says

Diabetes Drug Effective For Fatty Liver Disease

Otsuka tops Vera with kidney drug data; Regenxbio sinks on Duchenne update

Texas Invests $50M in Psychedelic Drug Research into Ibogaine to Treat Addiction

Vera drug scores in closely watched study in rare kidney disease

New Drug Could Quell Uncontrolled High Blood Pressure

FDA Plans to Use AI to Speed Up Drug and Food Safety Reviews

Advancing Covalent Ligand and Drug Discovery beyond Cysteine

Abeona sells speedy drug review voucher for $155M

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide

FDA approves twice-yearly shot of Gilead drug for HIV prevention

Targeted Covalent Modification Strategies for Drugging the Undruggable Targets

Daiichi Sankyo struck gold with ‘ADC’ cancer drugs. Its new CEO has to figure out what’s next.

Insmed surges on lung drug data; Recursion cuts staff

PTC stock slides on new data for Huntington’s drug

Genetics is a missing link in kidney disease drug development

Reproductive health startup raises $65M for infertility drugs

Drug Effective Against Early Migraine Symptoms

Experimental Drug Lorundrostat Could Quell Uncontrolled High Blood Pressure

Top Scientific Data Platforms for AI-Driven Drug Discovery: What to Look For

GSK to buy liver disease drug for $1.2B

After rejections, AbbVie secures approval for Parkinson’s drug

CDD Vault Curves vs. GraphPad Prism: Which Tool is Best for Early-Stage Drug Discovery Data Analysis?

Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis

Summit lung cancer drug shows ‘striking’ benefit over Keytruda

Use of new approach methodology for hepatic safety assessment of covalent inhibitor drug candidates

Analyzing Oxygen Atom Distribution in FDA‐Approved Drugs to Enhance Drug Discovery Strategies

FDA clears CSL’s swelling disease drug; Regeneron loses 23andMe auction

GLP-1 Drugs Improve Outlook For Kidney Transplants

Stroke rehabilitation drug repairs brain damage

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

A decade of cancer immunotherapy: Keytruda, Opdivo and the drugs that changed oncology

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