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Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30

Covalent Modifiers

Nafizul Haque Kazi, Nikolas Klink, Kai Gallant, Gian-Marvin Kipka & Malte Gersch Nat Struct Mol Biol , 2025 [link] The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1parkin-driven mitophagy.

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Eisai wins over European regulators on Alzheimer’s drug Leqembi

BioPharma Drive: Drug Pricing

A key regulatory committee sided against the drug this summer. But an appeal from Eisai appears to have worked, teeing Leqembi up for authorization in a major market.

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FDA Will Begin to Regulate Thousands of Lab Tests

Drugs.com

Food and Drug Administration on Friday announced that it will for the first time regulate these vital diagnostic tools. FRIDAY, Sept. 29, 2023 -- Faced with growing reports of inaccurate clinical lab tests, the U.S. Many Americans might have.

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Researchers map how the brain regulates emotions

Science Daily: Pharmacology News

A new study is among the first of its kind to separate activity relating to emotion generation from emotion regulation in the human brain. The findings provide new insights that could help inform therapeutic treatments regarding mental health and drug addiction.

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European regulators probe suicide risk to Ozempic, other Novo drug Saxenda

BioPharma Drive: Drug Pricing

Three reports from Iceland spurred the EMA to evaluate whether certain Novo Nordisk drugs, including Ozempic, might cause thoughts of self harm.

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As drug shortages reach record highs, regulators weigh next steps

BioPharma Drive: Drug Pricing

With many chemotherapy and ADHD drugs stuck in stubbornly short supply, several agencies are looking for new solutions.

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European regulators want to know more about the risks of GLP-1 drugs

BioPharma Drive: Drug Pricing

The EMA's safety committee has more questions for makers of the in-demand therapies as it reviews whether the drugs are linked to the risk of suicidal thoughts.