Thu.Mar 07, 2024

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Interstellar signal linked to aliens was actually just a truck

Science Daily: Pharmacology News

Sound waves thought to be from a 2014 meteor fireball north of Papua New Guinea were almost certainly vibrations from a truck rumbling along a nearby road, new research shows. The findings raise doubts that materials pulled last year from the ocean are alien materials from that meteor, as was widely reported.

Research 323
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Boundless Bio, a Bayer-backed cancer biotech, seeks an IPO

BioPharma Drive: Drug Pricing

The startup, which has raised nearly $254 million privately, is in early testing with drugs designed to target particularly tough-to-treat tumors.

Drugs 307
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Children surpass a year of HIV remission after treatment pause

Science Daily: Pharmacology News

Four children have remained free of detectable HIV for more than one year after their antiretroviral therapy (ART) was paused to see if they could achieve HIV remission, according to new research. The children, who acquired HIV before birth, were enrolled in a clinical trial in which an ART regimen was started within 48 hours of birth and then closely monitored for drug safety and HIV viral suppression.

Treatment 323
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Carcinogen Benzene Can Form in Some Acne Treatments: Report

Drugs.com

THURSDAY, March 7, 2024 -- Some acne treatments may may banish blemishes but carry hidden dangers: A new report reveals high levels of the carcinogen benzene can form in products that contain the zit-fighting ingredient benzoyl peroxide.According.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Novo’s latest obesity pill spurs major weight loss in small trial

BioPharma Drive: Drug Pricing

Early results from a Phase 1 study suggest the drug, amycretin, could be as potent as injectable medicines already sold by Novo and rival Eli Lilly.

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More Trending

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NodThera says inflammation drug has positive effect in Parkinson’s

BioPharma Drive: Drug Pricing

The results from the privately held biotech add to early evidence supporting the potential of an increasingly popular drug target known as NLRP3 inflammasomes.

Drugs 293
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Shape-shifting ultrasound stickers detect post-surgical complications

Science Daily: Pharmacology News

Gastrointestinal surgeries carry risk of fluid leaks, a potentially life-threatening complication. But no existing methods can reliably and non-invasively detect these leaks. To address this unmet need, researchers developed a tiny, soft, flexible sticker that changes in shape inside the body, enabling standard ultrasound tech to detect leaks for earlier detection and intervention.

Research 293
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Sport Coach's Style Can Boost a Player's Mental Health

Drugs.com

THURSDAY, March 6, 2024 -- Athletes whose coaches are open, authentic and positive are more likely to have better mental health, a new study says.Athletes feel happier and deal with problems more easily if their coaches adopt an “authentic.

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Rock weathering and climate: Low-relief mountain ranges are largest carbon sinks

Science Daily: Pharmacology News

For many hundreds of millions of years, the average temperature at the surface of the Earth has varied by not much more than 20 degrees Celsius, facilitating life on our planet. To maintain such stable temperatures, Earth appears to have a 'thermostat' that regulates the concentration of atmospheric carbon dioxide over geological timescales, influencing global temperatures.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Many Labradors Become Obese and Research Shows Why

Drugs.com

THURSDAY, March 7, 2024 -- Nearly a quarter of Labrador retrievers are more likely to be obese due to a genetic “double-whammy,” a new study finds.This gene mutation causes Labradors to both feel hungry all the time and also burn fewer.

Research 246
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Earth's earliest forest revealed in Somerset fossils

Science Daily: Pharmacology News

The oldest fossilized forest known on Earth -- dating from 390 million years ago -- has been found in the high sandstone cliffs along the Devon and Somerset coast of South West England.

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ER Visits for Infant, Child Melatonin Poisonings Are Soaring

Drugs.com

THURSDAY, March 7, 2024 -- As more Americans pop over-the-counter melatonin to help them sleep, their young children are increasingly showing up in ERs after accidentally ingesting the supplements.A new report of data from 2012 through 2021 finds a.

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Loss of nature costs more than previously estimated

Science Daily: Pharmacology News

Researchers propose that governments apply a new method for calculating the benefits that arise from conserving biodiversity and nature for future generations.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Alabama Passes Law Protecting IVF Following Frozen Embryo Ruling

Drugs.com

THURSDAY, March 7, 2024 -- Just three weeks after the Alabama Supreme Court ruled that frozen embryos should be considered children, lawmakers in that state passed legislation that shields both patients and providers who use in vitro fertilization.

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Baby quasars: Growing supermassive black holes

Science Daily: Pharmacology News

The James Webb Space Telescope makes one of the most unexpected findings within its first year of service: A high number of faint little red dots in the distant Universe could change the way we understand the genesis of supermassive black holes.

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Even a Little Daily Exercise Cuts Your Stroke Risk

Drugs.com

THURSDAY, March 6, 2024 -- Even a little physical activity can cut a person’s stroke risk compared to being a complete couch potato, a new review shows.Folks whose physical activity levels fell short of recommended guidelines still had a lower.

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Lost tombs and quarries rediscovered on British military base in Cyprus

Science Daily: Pharmacology News

Archaeologists rediscovers 46 sites at the Eastern Sovereign Base Area at Dhekelia, Cyprus. Archaeologists located sites from archive records, a number of which were thought to have been 'lost.' They uncovered evidence of quarries and tombs likely to span from the Bronze Age, Byzantine, Hellenistic and Roman periods.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Ozempic Eases Fatty Liver Disease in People Living With HIV

Drugs.com

THURSDAY, March 7, 2024 -- There's more good news around the diabetes and weight-loss drug Ozempic: It might help ease fatty liver disease in people living with HIV, new research shows.Six months of weekly injections of Ozempic (semaglutide).

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LACTOSE-Free Medicines: Which Drugs Contain LACTOSE?

Drug Patent Watch

LACTOSE-Free Medicines, 2024 is part of DrugPatentWatch’s deep library of business intelligence on biopharmaceutical drugs. Buy Lactose-Free Medicines from Amazon This guide is designed to provide information for healthcare providers to… The post LACTOSE-Free Medicines: Which Drugs Contain LACTOSE? appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 111
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Analysis Showed Maine Mass Shooter Had Blast-Related Brain Damage

Drugs.com

THURSDAY, March 7, 2024 -- The perpetrator of a mass shooting in Maine last fall had extensive brain damage from "thousands of low-level blasts" tied to his work at an Army Reserve hand grenade training range, a new report shows.On Oct. 25, Robert.

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How to Run DMC? It’s Tricky – FDA’s New Draft Guidance Provides Updated Recommendations on How to Best Use Data Monitoring Committees in Clinical Trials

FDA Law Blog: Drug Discovery

By Mark A. Tobolowsky & Véronique Li, Senior Medical Device Regulation Expert & David B. Clissold — The trio of CDER, CBER, and CDRH released a new draft guidance titled “ Use of Data Monitoring Committees in Clinical Trials ” that revises the 2006 guidance “Establishment and Operation of Clinical Trial Data Monitoring Committees” and, when final, will replace the 2006 guidance.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Food Allergies in College 101: Tips to Cope

Drugs.com

THURSDAY, March 7, 2024 -- Food allergies are difficult to manage at any age, but college students face complex challenges when it comes to navigating the dangers posed by the possibility of life-threatening anaphylaxis. A recent review published.

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Progress Towards a PAM-Free CRISPR

addgene Blog

The PAM… that sneaky little bit of sequence that you hope is present next to the "perfect" guide sequence for your genome engineering experiment. With CRISPR entering the clinic for correction of disease-causing alleles, and the growing need for gene editing in research, the old PAM constraints just won’t cut it anymore. Say hello to PAM-free and PAM-flexible nucleases!

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Is 'Selfie' Culture Driving Folks to Cosmetic Surgery?

Drugs.com

THURSDAY, March 7, 2024 -- The “selfie” culture on social media appears to be intensifying people’s desires to undergo cosmetic procedures, a new study suggests.Time spent on Snapchat or Instagram seems to heighten a person’s interest in.

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New patent expiration for Takeda Pharms drug ULORIC

Drug Patent Watch

Annual Drug Patent Expirations for ULORIC Uloric is a drug marketed by Takeda Pharms Usa and is included in one NDA. It is available from one supplier. There are three… The post New patent expiration for Takeda Pharms drug ULORIC appeared first on DrugPatentWatch - Make Better Decisions.

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Living Near Green Spaces Could Strengthen Your Bones

Drugs.com

THURSDAY, March 7, 2024 -- Living close to trees and other greenery could be keeping your bones strong, a new 12-year study suggests.Folks whose residences were near spots deemed "green" by satellite imagery tended to have better bone density than.

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Synthesis, in silico screening, and biological evaluation of novel pyridine congeners as anti?epileptic agents targeting AMPA (??amino?3?hydroxy?5?methylisoxazole) receptors

Chemical Biology and Drug Design

Synthesis, in silico screening, and anti-epileptic activity of novel pyridine analogs. Abstract The research involves the synthesis of a series of new pyridine analogs 5(i-x) and their evaluation for anti-epileptic potential using in silico and in vivo models. Synthesis of the compounds was accomplished by using the Vilsmeier-Haack reaction principle.

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Beclin-1-derived peptide MP1 attenuates renal fibrosis by inhibiting the Wnt/{beta}-Catenin pathway [Gastrointestinal, Hepatic, Pulmonary, and Renal]

ASPET

Renal fibrosis is distinguished by the abnormal deposition of extracellular matrix (ECM) and progressive loss of nephron function, with a lack of effective treatment options in clinical practice. In this study, we discovered that the Beclin-1-derived peptide MP1 significantly inhibits the abnormal expression of fibrosis and Epithelial-mesenchymal transition (EMT)-related markers, including α-Smooth muscle actin (α-SMA), Fibronectin (FN), Collagen I (Col I), Matrix metallopeptidase 2 (M

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Ag2O?TiO2?NTs enhance osteogenic activity in vitro by modulating TNF??/??catenin signaling in bone marrow?derived mesenchymal stem cells

Chemical Biology and Drug Design

BMSCs were isolated from the femurs of SD rats aged 7–8 weeks and identified by flow cytometry. BMSCs were inoculated into Ag2O-TiO2-NTs and added into stem cell osteogenic induction differentiation culture medium. Extracellular LDH enzyme activity was detected at 7 and 14 days of induction, respectively, and osteogenic genes in BMSCs were detected by qRT-PCR.