Thu.Jun 06, 2024

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Five 2024 breakthroughs in cancer drug research

Drug Discovery World

With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting , taking place from 30 May to 3 June, the drug discovery announcements have been coming thick and fast, with many new cancer therapies making significant strides forward in our ability to treat the disease. Lorbrena advances lung cancer treatment New data show that an unprecedented 60% of patients with advanced lung cancer given Lorbrena (lorlatinib) remain alive without disease progression after five years.

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In review of Lilly Alzheimer’s drug, FDA staff focus on safety, patient selection

BioPharma Drive: Drug Pricing

The agency is seeking input from an advisory panel on whether donanemab is effective across different groups of Alzheimer's patients, and on an unusual dosing strategy used by Lilly.

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Cancer vaccine shows sustained improvement in survival rates

Drug Discovery World

Cancer vaccine mRNA-4157 (V940) in combination with Keytruda reduced the risk of recurrence or death by 49% in patients with resected high-risk melanoma, according to follow-up data presented at ASCO 2024. The combination therapy was also shown to reduce the risk of distant metastasis or death by 62% compared to Keytruda alone in these patients. Professor Charles Swanton, Cancer Research UK’s chief clinician, said the melanoma trial results were “extremely impressive”, adding: “The new vaccine a

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Statins, Metformin Can Cut Odds for Brain Aneurysms

Drugs.com

THURSDAY, June 6, 2024 -- Common drugs used to control cholesterol, blood sugar and high blood pressure might also lower a person’s risk of stroke, a new study finds.The researchers evaluated the risk of brain aneurysms that cause bleeding strokes i.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Ozempic reduces risk of 13 types of cancer

Drug Discovery World

Patients taking semaglutide (the active ingredient in Wegovy and Ozempic) were 19% less likely to develop 13 obesity-related cancers, according to new data presented at ASCO 2024. The research, led by the Case Western Reserve University in Ohio and reported in The Guardian , also found patients were half as likely to die over 15 years compared with patients not taking a GLP-1 receptor agonist (RA).

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Artificial Sweetener Xylitol Linked to Heart Attack, Stroke

Drugs.com

THURSDAY, June 6, 2024 -- Higher amounts of the artificial sweetener xylitol might raise the risk of heart attack and stroke, a new study warns.Xylitol is a zero-calorie sugar alcohol commonly used in sugar-free candy, chewing gum, baked goods and.

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It's Safe to Take GLP-1 Weight Loss Meds Before Surgery: Study

Drugs.com

THURSDAY, June 6, 2024 -- Despite recent concerns that taking Ozempic, Wegovy or other GLP-1 medications might be unsafe before a surgery, a new review has uncovered no such danger.The issue arose because weight-loss drugs slow gastric emptying.

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Webinar: Using AI, ML and lab automation in drug discovery

Drug Discovery World

In this free webinar , hosted by DDW and sponsored by Benchling, you will learn about technology through the lens of artificial intelligence (AI), machine learning and lab automation. It will take place on 11 June from 3:00 PM – 4:00 PM BST. You will hear from Jonathan Wingfield, Principal Scientist at AstraZeneca; Abraham Heifets, CEO at Atomwise; Raminderpal Singh, AI Expert at HitchhikersAI; and a joint presentation from Helen Liu-Mayo, Product Manager, Machine Learning at Benchling, an

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Underutilized Opportunities: Exploring Patent Term Extensions for Medical Devices

Drug Patent Watch

In a recent study published in the Expert Review of Medical Devices, researchers investigated the utilization of patent term extensions (PTEs) to extend regulatory timeframes for medical devices in the… Source

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Webinar: Leveraging digital PCR-based assays in biotherapy manufacturing

Drug Discovery World

Join DDW and Thermo Fisher Scientific on 20 June, 11AM EDT/4PM BST, for an exclusive webinar, ‘ Advancing biotherapy manufacturing: innovative strategies for residual DNA and viral titre quantitation using dPCR ’. This free event will feature insight from Thermo Fisher Scientific’s Jonas Buege, Senior Manager, Product Management, as well as Viki Mahen, Scientist III, Molecular Biology.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Ultrasound Device Delivers Meds to Better Fight Brain Tumors

Drugs.com

THURSDAY, June 6, 2024 -- One of the biggest obstacles to treating brain cancer is getting tumor-killing drugs past the blood-brain barrier that normally protects the brain from foreign invaders.Now, new research shows that ultrasound waves emitted.

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Younger children in school year are more commonly diagnosed with ADHD than their older classmates, says new study

Science Daily: Pharmacology News

New research has found that teachers may be attributing signs of age-related immaturity in children, to conditions such as Attention-Deficit/Hyperactivity Disorder (ADHD) or Autism Spectrum Disorder (ASD). The results of the study showed that the youngest students in a class, with birth dates just before the school entry cut-off date, were overrepresented among children receiving an ADHD diagnosis or medication for the condition.

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Salmonella Illness Linked to Cucumbers Now Reported in 25 States

Drugs.com

THURSDAY, June 6, 2024 -- An outbreak of salmonella illness linked to recalled cucumbers has now expanded to at least 162 cases in 25 states, U.S. health officials reported Wednesday.In an update issued from the the U.S. Centers for Disease Control.

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FDA Approved Oncology Drugs 2023

Crown Bioscience

In a significant development, the US Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) approved 55 new drugs in 2023. This marks the second-highest count in the past 30 years, with the highest being 59 new drug approvals in 2018 and represents an impressive 50% increase in drugs approved in 2022.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA Panel OKs New COVID Vaccine for Fall

Drugs.com

THURSDAY, June 6, 2024 -- A U.S. Food and Drug Administration advisory panel on Wednesday recommended updating the formula for COVID vaccines ahead of a fall campaign that will encourage Americans to get the latest shots.The unanimous vote.

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A new study reveals that marine cyanobacteria communicate

Science Daily: Pharmacology News

A breakthrough study changes the way we understand cyanobacteria, which are essential for the sustenance of life. The study shows that these organisms do not operate in isolation, but rather physically interact through membrane-nanotubes, which function as exchange bridges between cells.

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Patient in Mexico Dies From First Known Human Infection of H5N2 Strain of Bird Flu

Drugs.com

THURSDAY, June 6, 2024 -- A 59-year-old person in Mexico is the first human in the world known to be infected with the H5N2 strain of avian flu, and the patient died of complications linked to the illness, the World Health Organization reported.

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People feel more connected to 'tweezer-like' bionic tools that don't resemble human hands

Science Daily: Pharmacology News

Some say the next step in human evolution will be the integration of technology with flesh. Now, researchers have used virtual reality to test whether humans can feel embodiment -- the sense that something is part of one's body -- toward prosthetic 'hands' that resemble a pair of tweezers. They report that participants felt an equal degree of embodiment for the tweezer-hands and were also faster and more accurate in completing motor tasks in virtual reality than when they were equipped with a vi

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Long COVID's Toll Outlined in New Report

Drugs.com

THURSDAY, June 6, 2024 -- Long COVID continues to plague millions of Americans as the health costs of the pandemic linger four years later, a new report warns.In a hefty document released Wednesday, the National Academies of Sciences, Engineering.

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Regenerating damaged heart cells in mice

Science Daily: Pharmacology News

Scientists have discovered a way to regenerate damaged heart muscle cells in mice, a development which may provide a new avenue for treating congenital heart defects in children and heart attack damage in adults, according to a new study.

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Many Americans Are Using Marijuana to Manage Health Issues

Drugs.com

THURSDAY, June 6, 2024 -- One in six patients serviced by a major California health care system said they used marijuana regularly, with many citing health reasons for doing so, a new study finds.In most cases, doctors may not know that weed is.

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Planet-forming disks around very low-mass stars are different

Science Daily: Pharmacology News

Using the James Webb Space Telescope, a team of astronomers studied the properties of a planet-forming disk around a young and very low-mass star. The results reveal the richest hydrocarbon composition seen to date in a protoplanetary disk, including the first extrasolar detection of ethane and a relatively low abundance of oxygen-bearing species. By including previous similar detections, this finding confirms a trend of disks around very low-mass stars to be chemically distinct from those aroun

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Calls to U.S. Poison Control Centers Are Becoming More Severe

Drugs.com

THURSDAY, June 6, 2024 -- America's poison control centers are increasingly fielding calls on cases of deliberate or accidental poisonings that end in disability or death, a new report finds.Researchers at the University of Virginia Health System.

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Exotic black holes could be a byproduct of dark matter

Science Daily: Pharmacology News

In the first quintillionth of a second, the universe may have sprouted microscopic black holes with enormous amounts of nuclear charge, MIT physicists propose. The gravitational pull from these tiny, invisible objects could potentially explain all the dark matter that we can't see today.

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Mpox Is Still Circulating Among U.S. Gay Men

Drugs.com

THURSDAY, June 6, 2024 -- Though not at numbers seen in the 2022 outbreak, mpox cases are still circulating in the United States, largely among gay and bisexual men, new government data shows. According to the U.S. Centers for Disease Control and.

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Antibodies 101: Flow Cytometry Controls

addgene Blog

When you are running flow cytometry, you’ll need various controls to help you set up and analyze your samples. While you are probably familiar with the basics of controls in experimental design, you’ll need a few controls specific to flow as an application. These controls will allow you to distinguish real results from background noise or nonspecific binding.

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Researchers upend theory about the formation of the Milky Way Galaxy

Science Daily: Pharmacology News

Research reveals a shocking discovery about the history of our universe: the Milky Way Galaxy's last major collision occurred billions of years later than previously thought.

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As biotech recovers, venture firms’ preferences appear to shift

BioPharma Drive: Drug Pricing

Venture investment into U.S. biotechs is back at pre-COVID levels. But firms seem more selective in the companies they favor, and some are looking toward M&A rather than IPOs for an exit.

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Lantern Pharma's Pioneering Role in AI-Driven Oncology Drug Development with the RADR® Platform

DrugBank

In the rapidly evolving landscape of oncology drug development, artificial intelligence (AI) has emerged as a revolutionary force, altering not just the pace but the very methodology of discovery and development. Among the leaders of this transformation is Lantern Pharma , a company that has seamlessly integrated AI into its core R&D and clinical development operations.

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Fish in schools have an easier time swimming in rough waters

Science Daily: Pharmacology News

Swimming through turbulent water is easier for schooling fish compared to solitary swimmers, according to a new study.

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FDA advisers back updating COVID shots to target JN.1 virus family

BioPharma Drive: Drug Pricing

The unanimous recommendation from the panel should help Novavax, which would have had difficulty adapting its shot in time if the committee picked a more specific subvariant.

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Mind Your Mind: Open Conversations for a Mentally Strong Workplace

BenchSci

Mental Health Awareness Month reminds us to prioritize mental well-being, challenge stigma, practice self-reflection, and encourage open conversations. At BenchSci, we embraced this month as an opportunity to spark dialogue and share resources through our internal Slack channel dedicated to mental health. Additionally, we hosted a panel discussion for BenchSciers, “Mind Your Mind: Open Conversations for a Mentally Strong Workplace.

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GSK acquires oligonucleotide drug startup Elsie

BioPharma Drive: Drug Pricing

The deal, worth up to $50 million, adds to a pipeline GSK is building around nucleic acid drugs, including its hepatitis B candidate bepirovirsen.

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Cellarium

Broad Institute

Cellarium By Rose Circeo June 6, 2024 Breadcrumb Home Cellarium The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tools for biostatistics, computational genomics, and variant annotation.