Tue.Jun 04, 2024

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New DDW Highlights podcast: 4 June 2024

Drug Discovery World

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The selected news highlights this week report breakthrough findings from early phase research and development, mainly preclinical studies and Phase I clinical trials, including a drug that can prevent sepsis deaths, a microbiome based immuno-oncology candidate, and a plant-based therapy

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Using AI to decode dog vocalizations

Science Daily: Pharmacology News

Have you ever wished you could understand what your dog is trying to say to you? Researchers are exploring the possibilities of AI, developing tools that can identify whether a dog's bark conveys playfulness or aggression.

Research 136
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DDW Highlights: 4 June 2024

Drug Discovery World

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The selected news highlights this week report breakthrough findings from early phase research and development, mainly preclinical studies and Phase I clinical trials, including a drug that can prevent sepsis deaths, a microbiome based immuno-oncology candidate, and a plant-based therapy

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FDA panel votes against MDMA therapy for PTSD, citing muddy data and safety concerns

BioPharma Drive: Drug Pricing

A group of independent experts wasn't convinced by clinical trial data from company Lykos Therapeutics, which is seeking FDA approval of MDMA-assisted treatment for post-traumatic stress disorder.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Immunotherapy prior to surgery a ‘game-changer’ for bowel cancer

Drug Discovery World

Phase II trial results have shown the superiority of immunotherapy pembrolizumab over chemotherapy when given before bowel cancer surgery. The results were presented by researchers at University College London (UCL) and UCLH at the American Society of Clinical Oncology (ASCO) Annual Meeting 2024. They are interim results from the NEOPRISM-CRC Phase II clinical trial in patients with stage two or stage three MMR deficient/MSI-High bowel cancer.

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Internet addiction affects the behavior and development of adolescents

Science Daily: Pharmacology News

Adolescents with an internet addiction undergo changes in the brain that could lead to additional addictive behavior and tendencies, finds a new study.

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Some countries could meet their total electricity needs from floating solar panels

Science Daily: Pharmacology News

Floating solar photovoltaic panels could supply all the electricity needs of some countries, new research has shown. The researchers calculated the daily electrical output for floating photovoltaics (FPV) on nearly 68,000 lakes and reservoirs around the world, using available climate data for each location.

Research 113
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GitHub – On-Prem Server Connectivity Using Self-Hosted Runners

Perficient: Drug Development

Various deployment methods, including cloud-based (e.g., CloudHub) and on-premises, are available to meet diverse infrastructure needs. GitHub, among other tools, supports versioning and code backup, while CI/CD practices automate integration and deployment processes, enhancing code quality and speeding up software delivery. GitHub Actions, an automation platform by GitHub, streamlines building, testing, and deploying software workflows directly from repositories.

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Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Science Daily: Pharmacology News

Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to cardiovascular disease (CVD) conditions are likely to triple by 2050, according to recent projections. At least 6 in 10 U.S. adults (61%), more than 184 million people, are expected to have some type of CVD within the next 30 years, reflecting a disease prevalence that will have a $1.8 trillion price tag in direct and indirect costs.

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Perficient Achieves AWS DevOps Competency

Perficient: Drug Development

Perficient is excited to announce our achievement in Amazon Web Services (AWS) DevOps Competency for AWS partners. This designation recognizes Perficient as an AWS partner that has demonstrated expertise in delivering Dev Sec Ops solutions. This competency highlights Perficient’s ability to drive innovation, meet business objectives , and get the most out of your AWS services.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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An anti-inflammatory curbs spread of fungi causing serious blood infections

Science Daily: Pharmacology News

Study finds that mesalamine, a common anti-inflammatory drug, can fight the fungus Candida albicans in the gut, potentially preventing the risk of invasive candidiasis in patients with blood cancers.

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Pharmacist Salaries and Employment in 2023: The Grass Keeps Getting Greener in Hospitals

Drug Channels

It’s time for the annual update to Drug Channels Institute’s (DCI) analysis of pharmacist salaries and employment. 2023 was another tough year for pharmacists working in retail settings. While average salaries grew, they did not keep pace with overall inflation. Pharmacist employment at drug stores shrank but grew at supermarkets and mass merchants.

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Giant viruses found on Greenland ice sheet

Science Daily: Pharmacology News

Giant viruses found on the Greenland ice sheet probably regulate the growth of snow algae on the ice by infecting them. Knowing how to control these viruses could help us reduce the rate of ice-melt.

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Wegovy, Ozempic May Help Curb Alcohol Dependence

Drugs.com

TUESDAY, June 4, 2024 -- Could the blockbuster GLP-1 meds like Wegovy and Ozempic have a role to play in helping people cut down on problem drinking? A new study suggests so.Researchers at Case Western Reserve University in Cleveland report that.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Rate of global warming caused by humans at an all-time high, say scientists

Science Daily: Pharmacology News

Global warming caused by humans is advancing at 0.26 C per decade -- the highest rate since records began, according to new research by over 50 leading international scientists.

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A Needle in a Base-Stack: Cas9 Structural Biology

addgene Blog

Have you ever designed a CRISPR guide RNA and wondered why it is limited to only 20 bases, or why it’s so important to choose a target sequence with a nearby protospacer-adjacent motif (PAM) ? Cas9 is becoming an ever more ubiquitous tool for genome engineering, and studying its structure can help us understand the parameters of CRISPR experimental design.

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Summer droughts in Northern hemisphere increasingly likely as seasonal streamflows change

Science Daily: Pharmacology News

Declining snowfall is changing the seasonal patterns of streamflow throughout the Northern hemisphere boosting chances of water shortages in the summer, scientists have found.

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Cucumbers Sold in 14 States Recalled Over Salmonella Concerns

Drugs.com

TUESDAY, June 4, 2024 -- A company recall has been issued for cucumbers sold in 14 states because of possible contamination with salmonella.In a notice posted by the U.S. Food and Drug Administration, Florida-based Fresh Start Produce recalled the.

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Human activity contributed to woolly rhinoceros' extinction

Science Daily: Pharmacology News

Researchers have discovered sustained hunting by humans prevented the woolly rhinoceros from accessing favourable habitats as Earth warmed following the Last Ice Age.

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AI Plus Mammograms Might Boost Breast Cancer Detection

Drugs.com

TUESDAY, June 4, 2024 -- Artificial intelligence (AI) can improve doctors’ assessments of mammograms, accurately detecting even the smallest breast cancers with fewer scary false positive readings, a new study shows.AI-assisted mammography detected.

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Gigantic Jurassic pterosaur fossil unearthed in Oxfordshire, UK

Science Daily: Pharmacology News

A team of palaeontologists has discovered a fossil of a gigantic flying reptile from the Jurassic period with an estimated wingspan of more than three metres -- making it one of the largest pterosaurs ever found from that era.

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Sleep Apnea Could Mean More Hospitalizations

Drugs.com

TUESDAY, June 4, 2024 -- Folks with sleep apnea are more likely to require hospitalization for an ailment, a new study shows.People aged 50 and older with sleep apnea have 21% higher odds of hospitalization compared to those without the breathing.

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The minor phytocannabinoid delta-8-tetrahydrocannabinol attenuates collagen-induced arthritic inflammation and pain-depressed behaviors [Behavioral Pharmacology]

ASPET

Patients with arthritis report using cannabis for pain management, and the major cannabinoid 9 -THC has anti-inflammatory properties, yet the effects of minor cannabinoids on arthritis are largely unknown. The goal of the present study was to determine the antiarthritic potential of the minor cannabinoid 8 -THC using the collagen-induced arthritis (CIA) mouse model.

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U.S. Maternal Death Rate Remains Much Higher Than Other Affluent Nations

Drugs.com

TUESDAY, June 4, 2024 -- Maternal mortality rates in the United States continue to exceed those in other wealthy nations, with most women dying during pregnancy and childbirth in ways that were preventable, a new report shows.In 2022, U.S. women.

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BridgeBio data show sustained benefit for achondroplasia drug

BioPharma Drive: Drug Pricing

Longer follow-up results from a mid-stage trial indicate the company’s treatment for a genetic cause of dwarfism may be competitive to an approved therapy from BioMarin Pharmaceutical.

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Black, Hispanic Americans More Likely to Be Dropped From Medicaid

Drugs.com

TUESDAY, June 5, 2024 -- Following the end of temporary pandemic-era rules expanding access to Medicaid, about 10 million Americans have lost that coverage.But a new report finds that most folks who've lost coverage have done so because of.

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New tentative approval for Annora Pharma drug brivaracetam

Drug Patent Watch

Brivaracetam is the generic ingredient in two branded drugs marketed by Ucb Inc, Aurobindo Pharma Ltd, Lupin Ltd, Sunshine, and Zydus Pharms and, and is included in seven NDAs.

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Too Much Sitting Could Be Harming Kids' Livers

Drugs.com

TUESDAY, June 4, 2024 -- Kids who spend more than six hours a day on their duffs have a greater risk of severe fatty liver disease and liver cirrhosis by the time they’re young adults, a new study claims.Children have 15% higher odds of fatty l.

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New tentative approval for MSN drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five… Source

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Very Early Menopause Could Raise Odds for Breast, Ovarian Cancers

Drugs.com

TUESDAY, June 4, 2024 -- Menopause before the age of 40 could raise a woman's long-term risk for breast or ovarian cancers, new research suggests. Besides that, "there is also higher risk of breast, prostate and colon cancer in relatives of these.

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Drug Patent Expirations for the Week of June 2, 2024

Drug Patent Watch

ILEVRO (nepafenac) Harrow eye Patent: 7,947,295 Expiration: Jun 8, 2024 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.

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How Drinking on Long-Haul Flights Could Threaten Your Heart

Drugs.com

TUESDAY, June 4, 2024 -- Booze could threaten a sleeping air passenger’s heart health, particularly on long-haul flights, a new study warns.Alcohol combined with cabin pressure at cruising altitude lowers the amount of oxygen in the blood and r.

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How to Successfully Prepare for the HTAR Implementation in the EU

thought leadership

Health technology developers (HTD) planning submission of a centralized Market Authorization Application (MAA) to the European Medicines Agency (EMA) should being preparing today for the implementation of the European Health Technology Assessment Regulation (HTAR). The HTAR will take effect in January 2025 for oncology and/or advanced therapy medicinal product (ATMP) therapies, with other therapies following a staggered implementation process, including orphan drugs in 2028 and all drugs in 2030

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Lawsuit Claims Poppi Soda Not as Gut-Healthy as Company Says

Drugs.com

TUESDAY, June 4, 2024 -- The popular prebiotic sodas known as Poppi may not be quite as good for your gut as the company claims.In a class-action lawsuit filed last week in U.S. District Court in San Francisco, Kristin Cobbs said she bought Poppi.

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