Chemical Biology and Drug Design

APRIL 4, 2025

Isocitrate dehydrogenase (IDH) is a key metabolic enzyme that catalyzes the conversion of isocitrate to -ketoglutaric acid (-KG). At present, there are few studies on the drug resistance of mIDH1 inhibitors. Therefore, this article first summarizes terms of IDH1 function from the molecular mechanism of IDH1, the mechanism of mutation, and the metabolism of substances due to mutations.

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Covalent Modifiers

APRIL 4, 2025

Amanda L. Waterbury, Jonatan Caroli, Olivia Zhang, Paloma R. Tuttle, Chao Liu, Jiaming Li, Ji Sung Park, Samuel M. Hoenig, Marco Barone, Airi Furui, Andrea Mattevi & Brian B. Liau Nat Commun 16 , 3156 (2025). [link] Chromatin modifiers often work in concert with transcription factors (TFs) and other complex members, where they can serve both enzymatic and scaffolding functions.

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Drug Channels

APRIL 4, 2025

This week, Im rerunning some popular posts while I prepare for todays live video webinar: PBM Industry Update: Trends, Challenges, and Whats Ahead. Click here to see the original post from January 2025. It's time for Drug Channels annual examination of U.S. brand-name drug pricing. For 2024, average brand-name drugs list prices grew by only 2.3%.

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Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- The U.S. Food and Drug Administration (FDA) has delayed the full approval of Novavaxs COVID-19 vaccine. The decision had been expected by April 1, but the agency now says it needs more information before moving forward.The.

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Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Science Daily: Pharmacology News

APRIL 4, 2025

A research group has discovered that using a device that stimulates the inner ear with a specific wavelength of sound reduces motion sickness. Even a single minute of stimulation with a unique sound, called 'sound spice ,' reduced the staggering and discomfort felt by people that were asked to read a document in a moving vehicle. Their findings suggest a simple and effective way to alleviate this common disorder.

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Research 234

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- An experimental blood test for Alzheimers disease not only can aid in its diagnosis but also indicate how far the brain condition has progressed, a new study says.The test tracks levels of a protein called MTBR-tau243, w.

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Disease 272

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- Disrespected by a neighbor or colleague? Eyerolls from servers at a restaurant or store? Denied a job or a mortgage due to skin color?More than half of Americans have experienced some such form of discrimination, and this.

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Science Daily: Pharmacology News

APRIL 4, 2025

Astronomers have discovered an extremely rare, high mass, compact binary star system only ~150 light years away. These two stars are on a collision course to explode as a type 1a supernova, appearing 10 times brighter than the moon.

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BioPharma Drive: Drug Pricing

APRIL 4, 2025

Sarepta and Roche will share the monitors' findings with EMA to resolve a temporary hold. Elsewhere, Allakos agreed to a buyout and high-dose Ocrevus missed a study goal.

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Trials Drugs 177

Science Daily: Pharmacology News

APRIL 4, 2025

Quantum states can only be prepared and observed under highly controlled conditions. A research team has now succeeded in creating so-called hot Schrodinger cat states in a superconducting microwave resonator. The study shows that quantum phenomena can also be observed and used in less perfect, warmer conditions.

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Research 171

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

BioPharma Drive: Drug Pricing

APRIL 4, 2025

Provider groups and health systems warn tariffs will test healthcare’s fragile supply chain, threatening to create disruptions to patient care.

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Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- Common chemicals used in plastic and personal care products may interfere with brain development in babies, a new study says.Phthalates are found in many everyday items, like food packaging, shampoo, toys and vinyl.

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BioPharma Drive: Drug Pricing

APRIL 4, 2025

Just two acquisitions in the first quarter, that of Intra-Cellular Therapies and IDRx, crossed the $1 billion mark, a notable decrease from the six seen during the same period last year.

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Therapies 150

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- Hospitals could be short-changing patients if they lean too heavily on nurse staffing agencies or overtime hours, a new study says.Patients are much more likely to develop bedsores at short-staffed hospitals that regularly.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Fierce BioTech

APRIL 4, 2025

AI-Powered Market Intelligence: Transforming Critical Decision-Making and Strategies in Global Healthcare pesurya Fri, 04/04/2025 - 10:55 Tue, 05/06/2025 - 09:00 Resource Type Webinar Promotion End Tue, 05/06/2025 - 12:01 In a rapidly evolving healthcare landscape, business strategies are becoming increasingly complex due to shifting payer expectations and market demographics, regulatory pressures, and dynamic market conditions.

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DS in Pharmatics

APRIL 4, 2025

The Prescription Drug User Fee Act (PDUFA) has been a cornerstone of the U.S. Food and Drug Administrations (FDA) drug approval process since its inception in 1992.

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FDA Pharmaceuticals Drugs 52

thought leadership

APRIL 4, 2025

The US Government recently modified their policy to utilize tariffs to in an effort to support the US economy. Pharmaceutical tariffs have been announced causing many global organizations to investigate the consequences of the tariffs on their overall product portfolio. Companies need to know the facts and have data to support their decisions.

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Government Pharmaceuticals Production Compliance 52

DS in Pharmatics

APRIL 4, 2025

Navigating the regulatory pathways for drug approvals in the U.S. can be complex, especially when determining whether a Biologics License Application (BLA) or a New Drug Application (NDA) is the appropriate route.

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Licensing Licensing FDA Marketing 52

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

thought leadership

APRIL 4, 2025

The US Government recently modified their policy to utilize tariffs to in an effort to support the US economy. Pharmaceutical tariffs of 25% have been forecasted causing many global organizations to investigate the consequences of the tariffs on their overall product portfolio. Companies need to know the facts and have data to support their decisions.

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Pharmaceuticals Regulations Government Production 52

DS in Pharmatics

APRIL 4, 2025

For early-stage drug developers, engaging with the FDA at the right time can be critical to success. One such opportunity is the INitial Targeted Engagement for Regulatory Advice on CBER/CDER ProducTs (INTERACT) meeting.

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FDA Drug Development Production Research 52

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- Cancer survivors can reduce their ongoing risk of death by sticking to diet and exercise guidelines recommended by the American Cancer Society, a new study suggests.Non-smoking survivors of obesity-related cancers had an.

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DS in Pharmatics

APRIL 4, 2025

The path to FDA drug approval involves several critical milestones, one of the most important being the Pre-New Drug Application (Pre-NDA) meeting. This crucial step provides pharmaceutical companies with an opportunity to engage with the FDA before submitting a New Drug Application (NDA).

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Pharmaceutical Companies FDA Pharmaceuticals Drugs 52

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- Antidepressants appear to increase peoples risk of sudden cardiac death, a new study says.People taking the mood meds are more likely to die suddenly from heart problems, and their risk rises the longer theyre on the dru.

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Alta Sciences

APRIL 4, 2025

Getting to the Heart of Science: How Clinical Research Saved My Life and Continues to Inspire Me pmjackson Fri, 04/04/2025 - 18:01 By Josiah Liang, Research Laboratory Technician, Clinical Diagnostic and Central Laboratory Services. How Clinical Research Saved My Life I was born in 2000. Had I been born 10 years earlier, I would have likely died from severe asthma.

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Clinical Research Science Research Research Laboratories 52

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- Americans received some protection against death during the COVID-19 pandemic if they lived in a state that had expanded its Medicaid program under the Affordable Care Act (ACA), a new study says.Even though death rates.

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Science Daily: Pharmacology News

APRIL 4, 2025

Low vaccination rates for influenza viruses and the lack of an HSV vaccine underscore the need for a new approach to reduce viral transmission. Researchers have now used a clinical-grade antiviral chewing gum to substantially reduce viral loads of two herpes simplex viruses and two influenza A strains in experimental models.

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DS in Pharmatics

APRIL 4, 2025

The Center for Biologics Evaluation and Research (CBER) plays a critical role in overseeing the approval of innovative biologic products, including gene therapies, cell-based treatments, and vaccines.

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Vaccine Therapies Treatment Production 52

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- A federal judge has stopped the Trump administration from cutting $11 billion in public health funding -- at least for now.U.S. District Judge Mary McElroy, who was appointed by President Donald Trump in 2019, said Thursday.

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Science Daily: Pharmacology News

APRIL 4, 2025

A team of researchers led by a physics graduate student recently made the surprising discovery of what they call a 'shape-recovering liquid,' which defies some long-held expectations derived from the laws of thermodynamics. The research details a mixture of oil, water and magnetized particles that, when shaken, always quickly separates into what looks like the classically curvaceous lines of a Grecian urn.

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Research 230

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- The U.S. Centers for Disease Control and Prevention (CDC) has not only lost nearly a fifth of its workforce, it has also been directed to slash $2.9 billion in contract spending.Thats about 35% of its total contract b.

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Disease 238

Chemical Biology and Drug Design

APRIL 4, 2025

Our deep learning framework, combining ProtTrans and multiwindow convolutional neural networks (CNNs), achieved high predictive accuracy for NAD-binding sites, with area under the curves (AUCs) of 0.9733 for human sirtuin proteins and 0.9701 for other NAD-dependent deacylation enzymes. This approach advances the understanding of sirtuin roles in aging and therapeutic potential.

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Disease Research 100

Drug Target Review

APRIL 4, 2025

Co-founded and led by CEO Cameron Owen, rBio is a biotech company making a significant impact in the biosimilar insulin market. By combining synthetic biology with advanced biomanufacturing techniques, rBio is set to reshape the production of these vital medications. With a commitment to making insulin biosimilars more affordable and accessible, rBio is addressing a critical need for patients across the globe.

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