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Hayden A. Sharma, Michael Bielecki, Meredith A. Holm, Ty M. Thompson, Yue Yin, Jacob B. Cravatt, Timothy B. Ware, Alex Reed, Molhm Nassir, Tamara El-Hayek Ewing, Bruno Melillo, J. Fernando Bazan, Phil S. Baran, and Benjamin F. Cravatt Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.5c01944 Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds (stereoprobes) offers a versatile way to discover covalent ligands for proteins in native b
FRIDAY, April 25, 2025 Novavaxs COVID-19 vaccine could soon receive full approval from the U.S. Food and Drug Administration (FDA), the company said Wednesday.The update sent Novavaxs stock up more than 21% in early trading. It also helped ease.
R. Justin Grams, Wesley J. Wolfe, Robert J. Seal, James Veccia, and Ku-Lung Hsu Journal of Medicinal Chemistry 2025 [link] Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-dependent cancers. Interest in developing selective inhibitors has produced tool compounds for the inactivation or degradation of AKR1C3 with varying degrees of selectivity among the
FRIDAY, April 25, 2025 -- On Tuesday, the U.S. Department of Health and Human Services announced that the government will invest $176 million in Moderna to expedite the creation of a pandemic influenza vaccine, according to a report from the.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
A new study provides new evidence that sensory stimulation of a gamma-frequency brain rhythm may promote broad-based restorative neurological health response.
The drug, being developed for a rare genetic disorder and currently under review in the U.S., is seen by some investors as critical to Biohaven’s future.
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The drug, being developed for a rare genetic disorder and currently under review in the U.S., is seen by some investors as critical to Biohaven’s future.
A landmark study reveals that a single oral dose of baloxavir marboxil (baloxavir) significantly reduces the transmission of influenza within households, marking a major advancement in influenza management. The trial provides robust evidence that an antiviral treatment can curb the spread of influenza to close contacts.
Quercetin is the core component of Hedyotis diffusa against breast cancer (BRCA). CDK1, BIRC5, and HSP90AA1 play key roles in the anti-BRCA effect of Hedyotis diffusa. ABSTRACT Hedyotis diffusa , a famous Traditional Chinese Medicine (TCM), has been extensively used clinically for thousands of years. Although the therapeutic effect of Hedyotis diffusa on tumors has attracted wide attention, components, and mechanisms against breast cancer (BRCA) have not been fully understood.
FRIDAY, April 25, 2025 -- Bad habits like smoking, heavy drinking and skipping exercise can start to impact a persons health as early as their mid-30s, a new study says.In fact, those three specific vices mean poorer physical and mental health s.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
The CRISPR company is laying off about a third of its employees and stopping work on an experimental lupus treatment in a bid to focus resources on a pair of cancer cell therapies.
FRIDAY, April 25, 2025 Breathing the air in nearly half of the United States could be putting the health of residents at risk.A new American Lung Association report shows that 156 million people live in areas with unhealthy air.The groups annual.
The company is looking to the highly anticipated launch of a closely watched HIV medicine to offset weakening demand for Trodelvy and its cancer cell therapies.
FRIDAY, April 25, 2025 -- Doctors can accurately predict a persons risk of fatty liver disease as early as 16 years before symptoms develop, a new study says.A blood test looking for five specific proteins can predict metabolic d.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Inavolisib WeightAverage: 407.378 Monoisotopic: 407.140510438 Chemical FormulaC 18 H 19 F 2 N 5 O 4 GDC-0077 CAS 2060571-02-8 GDC0077 RG6114 WHO 11204 GDC 0077 GDC-0077 RG-6114 RG6114 RO-7113755 RO7113755 FDA APPROVED, 10/10/2024, Itovebi , To treat locally advanced or metastatic breast cancer Drug Trials Snapshot (2 S )-2-[[2-[(4 S )-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazoli
FRIDAY, April 25, 2025 -- Risk factors for dementia could start taking their toll as early as a persons 20s and 30s, a new study says.Younger adults who carry known risks for dementia performed worse on memory and thinking tests between ages 24 a.
Halozyme claims Merck infringed on patents in developing a subcutaneous form of Keytruda. Elsewhere, Vanda’s challenge to an FDA rejection dragged on, while Sanofi revealed an immune drug setback.
FRIDAY, April 25, 2025 Health officials in California are now offering gift cards to encourage folks near farms to get tested for bird flu.The project is a partnership between the state and the U.S. Centers for Disease Control and Prevention (.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Navigating the complexities of drug development demands more than internal resources. From overcoming technical hurdles and avoiding costly or inappropriate development paths to meeting regulatory standards, every stagediscovery to marketpresents unique challenges. At key moments, companies must recognize when external expertise isn't just helpful but crucial.
FRIDAY, April 25, 2025 -- Doctors might be able to predict a newborn's long-term health outlook, by analyzing their umbilical cord blood, a new study says.Genetic clues found in cord blood can offer early insight into which infants are at higher.
It's no secret that our waistlines often expand in middle-age, but the problem isn't strictly cosmetic. Belly fat accelerates aging and slows down metabolism, increasing our risk for developing diabetes, heart problems and other chronic diseases. Exactly how age transforms a six pack into a softer stomach, however, is murky. New research shows how aging shifts stem cells into overdrive to create more belly fat.
FRIDAY, April 25, 2025 Four specific genes serve as a telltale clue to how potentially deadly stomach cancers will develop and progress, a new study says.Testing for these genetic mutations could enable doctors to offer targeted treatments and s.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Astronomers have discovered that super-Earth exoplanets are more common across the universe than previously thought. While it can be relatively easy to locate worlds that orbit close to their star, planets with wider paths can be difficult to detect. Still, researchers estimated that for every three stars, there should be at least one super-Earth present with a Jupiter-like orbital period, suggesting these massive worlds are extremely prevalent across the universe.
FRIDAY, April 25, 2025 -- A Kaiser Permanente colon cancer screening initiative put a huge dent in cancer cases and deaths over two decades, a new study says.The systematic outreach program doubled colon cancer screening rates, researchers are.
Bocodepsin, OKI-179 CAS 1834513-65-3 1834513-67-5 (besylate) K5D067O1SW S-((3E)-4-((6S,9S)-12,12-DIMETHYL-4,8,11,14-TETRAOXO-9-(PROPAN-2-YL)-7-OXA -3,10,13-TRIAZA-1(2,4)-(1,3)THIAZOLACYCLOTETRADECAPHAN-6-YL)BUT-3-EN-1-YL) (2S)-2-AMINO-3-METHYLBUTANETHIOATE S-(4-((7S,10S)-4,4-DIMETHYL-2,5,8,12-TETRAOXO-7-(PROPAN-2-YL)-9-OXA-16-THIA- 3,6,13,18-TETRAAZABICYCLO(13.2.1)OCTADECA-15(18),17-DIEN-10-YL)BUT-3-EN-1-YL) (2S)-2-AMINO-3-METHYLBUTANETHIOATE Molecular Weight 581.75 Formula C 26 H 39 N 5 O 6 S 2
In Part 2 , we integrated Azure AI Search with Azure Personalizer to build a smarter, user-focused experience in Optimizely CMS. We used ServiceAPI to send CMS content to Azure AI Search. In Part 3, well take things a step further: enabling users to ask natural language questions and get AI-powered answers. But here’s the twist: instead of using ServiceAPI, this time well explore how to query indexed content directly using Azure AI Searchs REST API.
Predictive Sales Intelligence: Scalable Strategies You Can Implement Today This white paper will explore the value of this right-now capability and how developments in causal AI are making it possible in a fast-moving, data-driven universe of tools and technologies. Download now. sdees Fri, 04/25/2025 - 15:56 This white paper will explore the value of this right-now capability and how developments in causal AI are making it possible in a fast-moving, data-driven universe of tools and technologie
On Aug. 16, 2022, Congress signed the Inflation Reduction Act (IRA) into law. This marked the largest reform to the United States health care access landscape since the Affordable Care Act in 2010. The IRA has several provisions with widespread impact to the pharmaceutical industry, and the objective of its Medicare-related provisions falls into two categories: Reduce prescription drug prices Reduce beneficiary cost sharing and premiums While these changes apply to Medicare only, they are likely
As technology continues to advance, patients and care teams expect to seamlessly engage with tools that support better health and accelerate progress. These developments demand the rapid, secure, scalable, and compliant sharing of data. By aligning enterprise and business goals with digital technology, healthcare organizations (HCOs) can activate strategies for transformative outcomes and improve experiences and efficiencies across the health journey.
Todays guest post comes from Scott Hughes, Vice President of Strategy of CareMetx. In this latest analysis from CareMetx, Scott explores how the Inflation Reduction Act (IRA) is reshaping Medicare patients access to critical medications across three high-impact therapeutic areas: immunology, oncology, and endocrinology. Drawing on fresh 2025 plan data, he highlights the emerging barriers faced by patients, the shifting demands on providers, and the strategic implications for drug manufacturers.
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