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Tomonori Tamura and Itaru Hamachi Accounts of Chemical Research 2025 58 (1), 87-100 DOI: 10.1021/acs.accounts.4c00628 Selective chemical modification of endogenous proteins in living systems with synthetic small molecular probes is a central challenge in chemical biology. Such modification has a variety of applications important for biological and pharmaceutical research, including protein visualization, protein functionalization, proteome-wide profiling of enzyme activity, and irreversible inhi
Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the tally of failed drugs in the innovative “Healey platform trial” to seven.
A newly described dinosaur whose fossils were recently uncovered is challenging the existing narrative, with evidence that the reptiles were present in the northern hemisphere millions of years earlier than previously known.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
TUESDAY, Jan. 7, 2025 -- The U.S. Food and Drug Association (FDA) released the first-ever guidelines for levels of lead in processed baby foods this week. However, many health and safety advocates say they are not satisfied with the guidance.Under.
The startup, which has already raised more than half a billion dollars, released Phase 2 results that could position its drug as a future threat to weight loss medicines from Novo Nordisk and Eli Lilly.
TUESDAY, Jan. 7, 2025 -- Fluoride exposure appears to slightly decrease IQ scores in children, a new federal meta-analysis has concluded -- but not at the low levels recommended for U.S. drinking water. Fluoride in drinking water was associated.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
TUESDAY, Jan. 7, 2025 -- Fluoride exposure appears to slightly decrease IQ scores in children, a new federal meta-analysis has concluded -- but not at the low levels recommended for U.S. drinking water. Fluoride in drinking water was associated.
TUESDAY, Jan. 7, 2025 -- Patients have more access to their own medical test results than ever before, thanks to legislation requiring results be released as soon as theyre available.But thats not necessarily a good thing, a new study warns.Many p.
It's time for Drug Channels annual examination of U.S. brand-name drug pricing. For 2024, average brand-name drugs list prices grew by only 2.3%. Whats more, after adjusting for overall inflation, brand-name drug net prices dropped for an unprecedented seventh consecutive year. Details and additional commentary below. As I predicted two years ago , the combined impact of changes to Medicaid rebates, the Inflation Reduction Act (IRA), and novel formulary access strategies have led multiple m
TUESDAY, Jan. 7, 2025 -- More and more adults are stuck in the middle of their families, caring not only for their children but also for aging parents and other older family members.The mental and physical health of these sandwich carers is more l.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
When I last wrote about AI on this blog three years ago, I spoke of it being a tool with the potential to transform scientific discovery, but the application I described was primarily theoretical. For AI to be a meaningful tool in R&D, I argued, we needed better sources of truth better data sets that AI tools could query and learn from over time and technology capable of integrating multiples steps into a semi-automated system.
TUESDAY, Jan. 7, 2025 -- Pulse oximeters -- those tiny devices that measure blood oxygen levels with a quick clip to your finger -- may soon get a major upgrade to ensure they work just as well for people of all skin tones.The U.S. Food and Drug.
Generic drugs play a crucial role in providing affordable medication options to patients. However, many individuals still harbor misconceptions and doubts about the efficacy and safety of generic alternatives. As healthcare professionals, it’s our responsibility to educate patients about generic drugs and empower them to make informed decisions about their treatment options.
TUESDAY, Jan. 7, 2025 -- Kids with autism who speak more than one language tend to have fewer symptoms from their disorder.Being multilingual not only enhances their general cognitive abilities, but also helps them better control their daily.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
TUESDAY, Jan. 7, 2025 -- That cold sore on your lip might be painful and unsightly, but it could also be a harbinger of debilitating brain aging.The oral herpes virus appears to be linked with Alzheimers disease, suggesting that the common i.
People who drink coffee in the morning have a lower risk of dying from cardiovascular disease and a lower overall mortality risk compared to all-day coffee drinkers, according to new research.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
TUESDAY, Jan. 7, 2025 -- Worried about the risky sex you had last night?Using a common antibiotic following sex can dramatically reduce a persons risk of some sexually transmitted infections (STIs), a new study says.Taking doxycycline within 72 h.
TUESDAY, Jan. 7, 2025 -- A Louisiana resident has died after being hospitalized with bird flu in December of last year, marking the first known U.S. death from the virus. The patient who, "was over the age of 65 and was reported to have underlying.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
TUESDAY, Jan. 7, 2024 -- Its long been a mystery why folks need a flu vaccine every year, even though immunizations they got in childhood continue to protect them from measles and mumps.Researchers now think they know why vaccine effectiveness v.
A researcher has used advanced models that indicate that the formation of Pluto and Charon may parallel that of the Earth-Moon system. Both systems include a moon that is a large fraction of the size of the main body, unlike other moons in the solar system. The scenario also could support Pluto's active geology and possible subsurface ocean, despite its location at the frozen edge of the solar system.
Applications that run smoothly across numerous platforms are in demand more than ever in today’s ever-changing technological landscape. Introducing Microsoft’s robust framework,NET Multi-platform App UI (.NET MAUI ), which makes it easier to create native desktop and mobile apps with a single codebase.NET MAUI: What is it? NET MAUI is an open-source framework that lets programmers use C# and XAML to create Windows, macOS, iOS, and Android applications.
Goji berries are a ubiquitous superfood known for a multitude of health benefits, including their antibiotic properties. Researchers have now found an effective way to harvest silver nanoparticles from these berries. They created the nanoparticles by drying, grinding, and then filtering the goji berries to create an extract. Then, they added chemical silver nitrate (AgNO3) and reduced the solution.
A clinical genomicist harnesses team-based science to help rare-disease patients By Allessandra DiCorato January 7, 2025 Breadcrumb Home A clinical genomicist harnesses team-based science to help rare-disease patients Heidi Rehm convinced labs and scientists to work together and share data. This has helped many people with rare disease find answers.
If you like the smell of spring roses, the sounds of summer birdsong, and the colors of fall foliage, you have the stabilization of the ozone layer to thank for it. Located in the stratosphere, where it shields the Earth from harmful ultraviolet radiation, the ozone layer plays a key role in preserving the planet's biodiversity. And now we may have a better idea of why that took so long -- more than 2 billion years -- to happen.
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