Drugs.com
MAY 19, 2025
MONDAY, May 19, 2025 Cutting-edge GLP-1 weight-loss drugs appear to help lower cancer risk even beyond the benefits from dropping excess pounds, a new study says.First-generation GLP-1 drugs like liraglutide (Saxenda) and exenatide (Byetta) were a.
Science Daily: Pharmacology News
MAY 14, 2025
The northern white rhinoceros is one of the rarest animals on Earth, with just two females left and no natural way for the species to reproduce. Now, scientists have mapped the entire genome of a northern white rhino. This represents a crucial step toward bringing the critically endangered species back from the edge using advanced reproductive technologies.
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Covalent Modifiers
MAY 7, 2025
Xinyuan Wu, Jiayi Pan, Rufeng Fan, Yiwei Zhang, Chao Wang, Guoliang Wang, Jiaxiang Liu, Mengqing Cui, Jinfeng Yue, Rui Jin, Zhiqiang Duan, Mingyue Zheng, Lianghe Mei, Lu Zhou, Minjia Tan, Jing Ai, and Xiaojie Lu Journal of the American Chemical Society 2025 147 (18), 15469-15481 DOI: 10.1021/jacs.5c01712 Covalent small molecule drugs have emerged as a crucial support in precision therapy due to their high selectivity and robust potency.
Broad Institute
MAY 19, 2025
With AI, researchers predict the location of virtually any protein within a human cell By Corie Lok May 19, 2025 Breadcrumb Home With AI, researchers predict the location of virtually any protein within a human cell Trained with a joint understanding of protein and cell behavior, the model could help with diagnosing disease and developing new drugs.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
LifeSciVC
MAY 14, 2025
By Cody Tranbarger, EIR at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Its an interesting time to be thinking about space. Just a few months ago, SpaceX captivated and inspired the world by catching a reusable rocket booster with mechanical chopsticks for the first time. Meanwhile, humanitys march toward a multi-planetary future continues, with Mars on the itinerary for the 2030s (unless youre on Elon time ).
BioPharma Drive: Drug Pricing
MAY 14, 2025
The research collaboration, under which Septerna will receive more than $200 million in upfront and near-term fees, is the latest deal Novo has struck to expand its obesity pipeline.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
MAY 14, 2025
Archaeopteryx is the fossil that clearly demonstrated Darwin's views. It's the oldest known fossil bird, and it helps show that all birds -- including the ones alive today -- emerged from dinosaurs. And while the first Archaeopteryx fossil was found more than 160 years ago, scientists are continuing to learn new things about this ancient animal. A set of feathers never before seen in this species help explain why it could fly when many of its non-bird dinosaur cousins could not.
Covalent Modifiers
MAY 23, 2025
Danyang Hu, Hairong Zeng, Wenxuan Li, Ya Zhang, Xiaoqian Chi, Xiaoyu Liu, Haijing Zhang, Guangbo Ge, Xiaozhen Jiao, and Ping Xie Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.5c00563 Mammalian carboxylesterases play an important role in the hydrolysis of both endogenous substrates and xenobiotics bearing ester or amide bond(s). We previously reported that bysspectin A and its derivative LC-20W were potent reversible hCES2A inhibitors.
Broad Institute
MAY 21, 2025
Scientists create next generation of tools in battle against brain disease By Corie Lok May 21, 2025 Breadcrumb Home Scientists create next generation of tools in battle against brain disease The findings contained in eight studies could lead to targeted gene therapies for brain disorders. By Allen Institute May 21, 2025 Credit: Allen Institute Different populations of cells in the mouse brain, each one targeted with high specificity by one of the many new genetic tools developed by scientists a
Chemical Biology and Drug Design
MAY 10, 2025
Although it is currently only used in veterinary therapy, carprofen proves to be a molecule with a versatile therapeutic potential for human pharmacotherapy. Moreover, the molecule is a target in the drug discovery process for the development of new bioactive compounds. ABSTRACT Carprofen, a nonsteroidal anti-inflammatory drug (NSAID) derived from propanoic acid, is known for its analgesic and antipyretic properties.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
BioPharma Drive: Drug Pricing
MAY 31, 2025
AstraZeneca and Daiichi Sankyo’s drug extended survival by 30% compared to a widely used regimen, further establishing its importance as a second-line treatment option.
Drugs.com
MAY 14, 2025
WEDNESDAY, May 14, 2025 The U.S. Food and Drug Administration (FDA) plans to review and possibly remove prescription fluoride supplements for children from the market.The FDA announced Tuesday that it intends to conduct the review by Oct. 31, 2.
Science Daily: Pharmacology News
MAY 21, 2025
Astronomers have witnessed for the first time a violent cosmic collision in which one galaxy pierces another with intense radiation. Their results show that this radiation dampens the wounded galaxy's ability to form new stars.
Covalent Modifiers
MAY 28, 2025
Sara Amberntsson, Alison J Foster, Bhavik Chouhan, Stephen Wilkinson, Stephanie Harlfinger, Graham Smith, Jason G Kettle, Michael Niedbala, Stefan Kavanagh, Dominic P Williams Toxicology Research , 2025, 14, 3, tfaf054, [link] Interest in inhibiting target proteins through covalent binding mechanisms has increased in the last decade due to the potential for beneficial pharmacological properties.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Broad Institute
MAY 21, 2025
2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy By Corie Lok May 21, 2025 Breadcrumb Home 2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy The winners are Carl June, Bruce Levine, Isabelle Rivire, and Michel Sadelain, who developed technology that reprograms patients immune systems to target cancer, leading to several FDA-approved treatments given to over 45,000 cancer patients, including many who had exhausted all other op
Perficient: Drug Development
MAY 27, 2025
In the ever-evolving world of content management systems (CMS), there are many options to choose fromWordPress, Joomla, Drupal, and others. But for developers who love clean code, flexibility, and control, October CMS stands out as a modern, elegant solution built on the popular Laravel PHP framework. What is October CMS? October CMS is an open-source, free CMS that makes web building easier without compromising power or flexibility.
Drug Target Review
MAY 14, 2025
The integration of artificial intelligence (AI) into scientific workflows represents both tremendous opportunity and significant challenges. I recently discussed the subject with two founders at the cutting-edge of this transformation: Andr Frana of Ergodic and Eli Pollock of Ontologic. We explored the barriers scientists face when adopting AI tools , contrasting approaches to building AI systems for specialised domains, and their visions for how these technologies will reshape scientific work.
Drugs.com
MAY 14, 2025
WEDNESDAY, May 14, 2025 Exercise and sports appear to help kids avoid mental health problems as they grow into young adults, a new study says.Young children who participated in sports teams and physical education classes were less likely to d.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
MAY 15, 2025
New research shows that cyberbullying should be classified as an adverse childhood experience due to its strong link to trauma. Even subtle forms -- like exclusion from group chats -- can trigger PTSD-level distress. Nearly 90% of teens experienced some form of cyberbullying, accounting for 32% of the variation in trauma symptoms. Indirect harassment was most common, with more than half reporting hurtful comments, rumors or deliberate exclusion.
Covalent Modifiers
MAY 25, 2025
Dandan Zhu, Zijian Zheng, Huixin Huang, Xiaojuan Chen, Shuhong Zhang, Zhuchu Chen, Ting Liu, Guangyu Xu, Ying Fu, Yongheng Chen, European Journal of Medicinal Chemistry , 2025 [link] Fibroblast growth factor receptors (FGFRs) represent promising therapeutic targets in various malignancies, yet the clinical application of FGFR covalent inhibitors has been impeded by several significant challenges, including unquantifiable target engagement, undefined off-target effects, and the emergence of drug
Broad Institute
MAY 21, 2025
Genomic score predicts patients' progression to multiple myeloma By Tom Ulrich May 21, 2025 Breadcrumb Home Genomic score predicts patients' progression to multiple myeloma Mutation-based score provides a personalized indicator of disease severity and progression risk, could help inform early intervention strategies By Elizabeth Dougherty, Dana-Farber Cancer Institute May 21, 2025 Credit: NCI Visuals Online Multiple myeloma tumor cells (green) Related people Gad Getz Related programs Cancer Prog
LifeSciVC
MAY 21, 2025
By Ankit Mahadevia, former CEO of Spero Therapeutics and Atlas alumni, as part of the From The Trenches of LifeSciVC I recently read Yuval Noah Hariris Nexus ; what stuck with me was how a society uses information to create shared meaning can have a profound impact on peoples experiences. Hariri employs this lens to illustrate the significant differences between living in Moscow versus Michigan in the 1980s and Beijing versus Boston today.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drug Target Review
MAY 23, 2025
In the ever-evolving landscape of immuno-oncology, managing the side effects of advanced therapies has become just as important as enhancing their efficacy. Among the most concerning complications is cytokine release syndrome (CRS), a potentially life-threatening condition that frequently follows the administration of some CAR T-cell therapies and bispecific antibodies.
Drugs.com
MAY 14, 2025
WEDNESDAY, May 14, 2025 Significant weight gain paired with delayed or foregone motherhood nearly triples a young womans risk of later breast cancer, a new study says.Women were 2.7 times more likely to develop breast cancer if they:Had a more th.
Science Daily: Pharmacology News
MAY 14, 2025
Apples-to-apples comparisons in the distant universe are hard to come by. Whether the subject is dwarf galaxies, supermassive black holes, or 'hot Jupiters,' astronomers can spend months or years searching for comparable objects and formations to study. And it is rarer still when those objects are side-by-side. But a new study offers a road map for finding 'twin' planetary systems -- showing whether binary stars that orbit each other, and that were born at the same time and place, tend to host s
Covalent Modifiers
MAY 27, 2025
Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius, Neil Gibson, Irene C. Waizenegger, Daniel Gerlach, Martin Augsten, Fiona Spreitzer, Yukina Shirai, Masachika Ikegami, Sylvia Tilandyov, Dirk Scharn, Mark A. Pearson, Johannes Popow, Anna C. Obenauf, Noboru Yamamoto, Shunsuke Kondo, Frans L. Opdam, Annemarie Bruining, Shinji Kohsaka, Norbert Kraut, John V.
Broad Institute
MAY 27, 2025
Gene editing disrupts Huntingtons mutation in mice By Allessandra DiCorato May 27, 2025 Breadcrumb Home Gene editing disrupts Huntingtons mutation in mice Making single-letter edits in stretches of repeated DNA stopped or reversed the genetic change that causes Huntingtons disease and Friedreichs ataxia. By Allessandra DiCorato May 27, 2025 Credit: Agnieszka Grosso, Broad Communications Related news More versatile and efficient base editor unlocks new gene-editing targets Researchers extend powe
Perficient: Drug Development
MAY 15, 2025
Today, we celebrate Global Accessibility Awareness Day (GAAD) , an annual event dedicated to raising awareness about digital accessibility and inclusion for people with disabilities. Held every third Thursday in May, GAAD encourages individuals, businesses, and organizations to reflect on the importance of creating accessible digital experiences. While GAAD highlights the needs of people with disabilities, accessibility benefits everyone not just those with disabilities.
Drug Target Review
MAY 21, 2025
In an era where biotherapeutics are transforming the healthcare landscape, the organisation, Vitalant , is uniquely positioned to bridge the gap between cutting-edge therapies and community access. With decades of expertise and a deeply rooted presence in healthcare networks across the country, Vitalant is not just supporting the rise of novel therapies, its actively enabling them.
Drugs.com
MAY 14, 2025
WEDNESDAY, May 14, 2025 -- Artificial intelligence (AI) can help prevent breast cancers that develop between routine mammograms, by catching ones that trained radiologists would overlook, a new study says.Incorporating AI into mammography could.
Science Daily: Pharmacology News
MAY 14, 2025
Evidence of a unique T cell may explain why urban children are more prone to allergies than rural children. Differences in the development of the gut microbiome may be an underlying cause.
Covalent Modifiers
MAY 18, 2025
Nafizul Haque Kazi, Nikolas Klink, Kai Gallant, Gian-Marvin Kipka & Malte Gersch Nat Struct Mol Biol , 2025 [link] The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1parkin-driven mitophagy. Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is currently being explored in a clinical trial for Parkinsons disease.
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