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Increased use of ventilation and air cleaners, designed to mitigate the spread of viral infections in hospitals, is likely to have unpredictable effects and may cause viral particles to move around more, according to a new study.
The remarkable therapeutic potential of luteolin against cervical cancer can be ascribed to its profound influence on amino acid and nucleotide metabolism, substantiated by the seamless integration of metabolomics, bioinformatics, and molecular docking techniques in this comprehensive investigation. ABSTRACT The incidence of cervical cancer is high among women globally.
By Mark A. Tobolowsky & Charles G. Raver & James E. Valentine We recently blogged about a new December 2024 draft guidance about accelerated approval (the December 2024 draft guidance). That post largely focused on endpoints as well as the broader context for when accelerated approval is appropriate. However, as we note in that post, the design, timing of initiation, and timely conduct of confirmatory trials are also important considerations in FDAs determination of whether accelerated
In today’s rapidly evolving web development landscape, creating interactive and dynamic user interfaces has become essential. Traditionally, developers relied on JavaScript frameworks like Vue.js or React to achieve this. However, Laravel developers now have an effective alternative: Laravel Livewire. Laravel Livewire enables developers to build dynamic, reactive components directly using PHP, eliminating the need for JavaScript.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Dr. Quinton Smith is a chemical engineer wearing a biologists hat. His lab at the University of California, Irvine, works on lifelike human organ models or miniature avatars of human tissues, according to Dr. Smith. Their goal is to generate lab-grown versions of human organs that are so accurate they can be used to test the impact of drugs outside of the body and study the earliest stages of human development.
William McCoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Miguel A. Corts Gonzlez, Sabina Cosulich, Nichola L. Davies, Nicolas Floch, Ryan Greenwood, David Hargreaves, Peng Huang, Thomas A. Hunt, Tony Johnson, Peter Johnstrm, Jason G. Kettle, Mikhail Kondrashov, Demetrios H. Kostomiris, Songlei Li, Andrew Lister, Scott Martin, Darren McKerrecher, Neville McLean, J.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
William McCoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Miguel A. Corts Gonzlez, Sabina Cosulich, Nichola L. Davies, Nicolas Floch, Ryan Greenwood, David Hargreaves, Peng Huang, Thomas A. Hunt, Tony Johnson, Peter Johnstrm, Jason G. Kettle, Mikhail Kondrashov, Demetrios H. Kostomiris, Songlei Li, Andrew Lister, Scott Martin, Darren McKerrecher, Neville McLean, J.
Software development techniques have rapidly improved because of the quick growth of technology, with Content Management Systems (CMS) and MVC (Model-View-Controller) frameworks performing a key role in the creation of contemporary online applications. These approaches do, however, have challenges in the fast-paced, high-demanding technological environment of today.
This blog post is part of a series that will explore applications and expansions of the Open Targets informatics ecosystem, particularly the Open Targets Platform and Open Targets Genetics through conversations with our users. Sam Wagenaar is a high school senior, who, during his internship last year with the Pachter Lab at the California Institute of Technology (Caltech), developed the gget opentargets module under the mentorship of Laura Luebbert and Joe Rich.
Coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for pancreatic lipase (PL) inhibition. Among the analogues, 5dh and 5de showed best PL inhibition, with IC 50 values of 9.20 and 11.4M, respectively, compared to Orlistat (IC 50 =0.97M). Analogue 5dh inhibited PL competitively with a K i of 4.504M. ABSTRACT A set of coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for their ability to impede pancreatic lipase (PL) activity.
Cancer remains one of the most complex and heterogeneous diseases, driven by genetic, epigenetic, and environmental factors. Understanding tumor evolution is pivotal for designing effective therapeutic strategies and overcoming treatment resistance. Advances in multi-omics analysis and biomarker discovery have ushered in a new era of precision oncology, enabling researchers to dissect tumor dynamics with unprecedented resolution.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
So, DeepSeek just dropped their latest AI models, and while its exciting, there are some cautions to consider. Because of the US export controls around advanced hardware, DeepSeek has been operating under a set of unique constraints that have forced them to get creative in their approach. This creativity seems to have yielded real progress in reducing the amount of hardware required for training high-end models in reasonable timeframes and for inferencing off those same models.
Maximizing Patent Protection: Strategies for Pharmaceutical Marketers As a pharmaceutical marketer, you know how crucial it is to protect your patented drug's market share. But with the ever-changing landscape of the industry, it can be challenging to stay ahead of the competition. In this post, we'll explore effective strategies for maximizing patent protection and exclusivity, ensuring your product remains a leader in the market.
This study investigates the effects and mechanisms of combining Polyphyllin VII (PPVII) with Docetaxel (DTX) in the treatment of prostate cancer (Pca). Experiments were conducted using DTX-sensitive DU-145 cells and DTX-resistant DU145/DTX cells. The results indicate that PPVII significantly enhanced the inhibitory effect of DTX, reduced cell viability, and promoted apoptosis and cell cycle arrest.
Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Why Security and Privacy Matter Security and privacy are not just best practices but legal requirements when handling customer data. Regulations like the General Data Protection Regulation (GDPR) in the EU, the California Consumer Privacy Act (CCPA) in California, and other global privacy laws mandate that businesses protect the privacy of individuals and ensure their data is stored and processed securely.
New 9H purine derivatives were designed and synthesized, and CDK9 inhibitory activity were evaluated. Compound B5 behaved as a highly selective inhibitors of CDK9. ABSTRACT Cyclin-dependent kinase 9 (CDK9) is considered as an important target in the research of antitumor drugs. Taking the CDK2/9 inhibitor CYC065 as the positive control and an in-house library compound ( 64 ) as the lead compound, four classes of 22 target compounds with 9H purine as the core structure were designed to establish
The startup says its specially constructed RNAi therapies can get deep into brain tissue, yielding new ways to treat neurological conditions like Huntington’s.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Part 1 of this new blog series will focus on what KubeOne is, its features, and its architecture. KubeOne aims to provide a reliable and automated solution for provisioning, managing, and scaling Kubernetes clusters. It focuses on high availability, self-healing, and ease of maintenance across multiple nodes and environments. What is KubeOne? KubeOne is an open-source tool for setting up, managing, and scaling Kubernetes clusters in environments such as public clouds, private clouds, and on-prem
FRIDAY, Jan. 31, 2025 -- The U.S. Food and Drug Administration (FDA) has approved Journavx, a new pain reliever without the risks of addiction or overdose linked to drugs like Vicodin and OxyContin. The new pill, developed by Vertex.
A pyrazolopyrimidine, 2-((4-methoxyphenyl)amino)-7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile exhibits TLR7 agonistic activity and stimulates an innate immune response in RAW264.7 macrophages. ABSTRACT Compounds containing pyrazolopyrimidine scaffolds were designed and synthesized as toll-like receptor 7 (TLR7) agonists. Thirty-three compounds, including 22 novel compounds, were prepared, and their structures were identified using nuclear magnetic resonance spectroscopy and mass spec
After decades of research, Vertex Pharmaceuticals now has an approved pain medication. Can one of the world’s most powerful biotechs contend with a healthcare system that’s long favored opioids?
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
GitHub Actions is an open-source CI-CD tool that is an extended feature of GitHub. It automates software workflows with world-class CI-CD. Build, Test, and deploy your code from GitHub. How GitHub Actions Work Workflows : Workflows are automated processes defined in the YAML file and triggered on an event like Push. Events : Events are operations that change the repository, like Pull Operations and Push Operations.
An interdisciplinary team of researchers has projected that if the rate of global CO2 emissions continues to increase and reaches a high emission scenario, sea levels would as a result very likely rise between 0.5 and 1.9 meters by 2100. The high end of this projection's range is 90 centimeters higher than the latest United Nations' global projection of 0.6 to 1.0 meters.
WEDNESDAY, Jan. 29, 2025 -- A popular diabetes drug just got a major new approval -- and it could be a game-changer for millions of Americans at risk for kidney failure. The U.S. Food and Drug Administration (FDA) has officially approved Ozempic to.
The clearance is a step forward in AstraZeneca and Daiichi Sankyo’s plan to position antibody-drug conjugates like Enhertu ahead of chemotherapy in a variety of tumors.
Our colleagues at Perficient are generous, kind, and take pride in paying it forward through a passion for philanthropy. In 2024, Perficients Giving Employee Resource Group (ERG) launched the Perficient Gives Global Grants Program, a unique opportunity to support global nonprofit organizations in their mission to make a significant impact in our communities.
In a comprehensive systematic review and meta-analysis, researchers have taken a deep dive into the effects of cold-water immersion on health and wellbeing. Analyzing data from 11 studies with 3177 participants, researchers found that cold-water immersion may lower stress, improve sleep quality, and boost quality of life.
TUESDAY, Jan. 28, 2025 -- Kansas health officials are fighting the largest tuberculosis (TB) outbreak in U.S. history, with 67 confirmed cases since new year began.The outbreak includes 60 active cases in Wyandotte County and seven in Johnson.
The approval adds a new indication for GLP-1 drugs and gives Novo an advantage over Lilly’s rival diabetes drug Mounjaro, which hasn’t yet proven it can improve outcomes in kidney disease.
Were excited to share that Sitecore has honored six of our Perficient colleagues with the prestigious title of Sitecore Most Valuable Professional across all three categoriesstrategy, technology, and ambassador. With this achievement, our total MVP recognitions now exceed 80. Together, our team has continued to reach new heights and set a benchmark of excellence for our Sitecore practice here at Perficient, Art Quinn, General Manager said.
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