Sat.Jan 25, 2025 - Fri.Jan 31, 2025

article thumbnail

Ventilation in hospitals could cause viruses to spread further

Science Daily: Pharmacology News

Increased use of ventilation and air cleaners, designed to mitigate the spread of viral infections in hospitals, is likely to have unpredictable effects and may cause viral particles to move around more, according to a new study.

Hospitals 278
article thumbnail

Combination of Metabolomics and Bioinformatics to Reveal the Mechanism of Luteolin in the Treatment of Cervical Cancer

Chemical Biology and Drug Design

The remarkable therapeutic potential of luteolin against cervical cancer can be ascribed to its profound influence on amino acid and nucleotide metabolism, substantiated by the seamless integration of metabolomics, bioinformatics, and molecular docking techniques in this comprehensive investigation. ABSTRACT The incidence of cervical cancer is high among women globally.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

When is a Confirmatory Trial “Underway” or Conducted with “Due Diligence” Enough for Accelerated Approval? FDA Explains Its New Authorities

FDA Law Blog: Drug Discovery

By Mark A. Tobolowsky & Charles G. Raver & James E. Valentine We recently blogged about a new December 2024 draft guidance about accelerated approval (the December 2024 draft guidance). That post largely focused on endpoints as well as the broader context for when accelerated approval is appropriate. However, as we note in that post, the design, timing of initiation, and timely conduct of confirmatory trials are also important considerations in FDAs determination of whether accelerated

FDA 105
article thumbnail

Laravel Livewire: Simplifying Dynamic Interfaces

Perficient: Drug Development

In today’s rapidly evolving web development landscape, creating interactive and dynamic user interfaces has become essential. Traditionally, developers relied on JavaScript frameworks like Vue.js or React to achieve this. However, Laravel developers now have an effective alternative: Laravel Livewire. Laravel Livewire enables developers to build dynamic, reactive components directly using PHP, eliminating the need for JavaScript.

article thumbnail

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

article thumbnail

Q&A with Keystone Fellow & 2025 Organoids meeting Organizer, Dr. Quinton Smith

keypoint

Dr. Quinton Smith is a chemical engineer wearing a biologists hat. His lab at the University of California, Irvine, works on lifelike human organ models or miniature avatars of human tissues, according to Dr. Smith. Their goal is to generate lab-grown versions of human organs that are so accurate they can be used to test the impact of drugs outside of the body and study the earliest stages of human development.

article thumbnail

N‐Substituted‐5‐ [(2,5‐Dihydroxybenzyl)amino]salicylamides as Lavendustin Analogs: Antiproliferative Activity, COMPARE Analyses, Mechanistic, Docking, ADMET and Toxicity Studies

Chemical Biology and Drug Design

N -substituted-5-([2,5-dihydroxybenzyl]-amino)salicylamides; 1 11 , exhibited invitro anticancer activity, with Compounds 4 , 5 , and 9 being most potent. COMPARE analysis showed polypharmacological multitargeting compounds. Compounds 4 , 5 , 9 11 displayed a remarkable EGFR-TK invitro inhibitory activity, induced apoptosis in NCI-H522 cell line, and showed predicted ADME pharmacokinetic profile.

More Trending

article thumbnail

Limitations of MVC Frameworks and CMS in Recent Days

Perficient: Drug Development

Software development techniques have rapidly improved because of the quick growth of technology, with Content Management Systems (CMS) and MVC (Model-View-Controller) frameworks performing a key role in the creation of contemporary online applications. These approaches do, however, have challenges in the fast-paced, high-demanding technological environment of today.

52
article thumbnail

Case study: gget’s new Open Target module

The Open Targets Blog

This blog post is part of a series that will explore applications and expansions of the Open Targets informatics ecosystem, particularly the Open Targets Platform and Open Targets Genetics through conversations with our users. Sam Wagenaar is a high school senior, who, during his internship last year with the Pachter Lab at the California Institute of Technology (Caltech), developed the gget opentargets module under the mentorship of Laura Luebbert and Joe Rich.

article thumbnail

Coumarin Analogues as Promising Anti‐Obesity Agents: In Silico Design, Synthesis, and In Vitro Pancreatic Lipase Inhibitory Activity

Chemical Biology and Drug Design

Coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for pancreatic lipase (PL) inhibition. Among the analogues, 5dh and 5de showed best PL inhibition, with IC 50 values of 9.20 and 11.4M, respectively, compared to Orlistat (IC 50 =0.97M). Analogue 5dh inhibited PL competitively with a K i of 4.504M. ABSTRACT A set of coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for their ability to impede pancreatic lipase (PL) activity.

Research 100
article thumbnail

Decoding Tumor Evolution: Insights from Longitudinal Multi-Omics Studies

Crown Bioscience

Cancer remains one of the most complex and heterogeneous diseases, driven by genetic, epigenetic, and environmental factors. Understanding tumor evolution is pivotal for designing effective therapeutic strategies and overcoming treatment resistance. Advances in multi-omics analysis and biomarker discovery have ushered in a new era of precision oncology, enabling researchers to dissect tumor dynamics with unprecedented resolution.

article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Is it really DeepSeek FTW?

Perficient: Drug Development

So, DeepSeek just dropped their latest AI models, and while its exciting, there are some cautions to consider. Because of the US export controls around advanced hardware, DeepSeek has been operating under a set of unique constraints that have forced them to get creative in their approach. This creativity seems to have yielded real progress in reducing the amount of hardware required for training high-end models in reasonable timeframes and for inferencing off those same models.

article thumbnail

Marketing Your Patented Drug Effectively: Strategies for Maximizing Patent Protection and Exclusivity

Drug Patent Watch

Maximizing Patent Protection: Strategies for Pharmaceutical Marketers As a pharmaceutical marketer, you know how crucial it is to protect your patented drug's market share. But with the ever-changing landscape of the industry, it can be challenging to stay ahead of the competition. In this post, we'll explore effective strategies for maximizing patent protection and exclusivity, ensuring your product remains a leader in the market.

article thumbnail

Polyphyllin VII Enhances the Sensitivity of Prostate Cancer Cells to Docetaxel by Promoting Mitochondrial Dysfunction and Inducing Ferroptosis

Chemical Biology and Drug Design

This study investigates the effects and mechanisms of combining Polyphyllin VII (PPVII) with Docetaxel (DTX) in the treatment of prostate cancer (Pca). Experiments were conducted using DTX-sensitive DU-145 cells and DTX-resistant DU145/DTX cells. The results indicate that PPVII significantly enhanced the inhibitory effect of DTX, reduced cell viability, and promoted apoptosis and cell cycle arrest.

article thumbnail

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Security and Privacy in Experience Cloud: Best Practices for Protecting Customer Data

Perficient: Drug Development

Why Security and Privacy Matter Security and privacy are not just best practices but legal requirements when handling customer data. Regulations like the General Data Protection Regulation (GDPR) in the EU, the California Consumer Privacy Act (CCPA) in California, and other global privacy laws mandate that businesses protect the privacy of individuals and ensure their data is stored and processed securely.

article thumbnail

Ocean-surface warming four times faster now than late-1980s

Science Daily: Pharmacology News

The study helps explain why 2023 and early 2024 saw unprecedented ocean temperatures.

348
348
article thumbnail

Design, Synthesis and Biological Evaluation of Novel 9H Purine Derivatives as Potent CDK9 Inhibitors

Chemical Biology and Drug Design

New 9H purine derivatives were designed and synthesized, and CDK9 inhibitory activity were evaluated. Compound B5 behaved as a highly selective inhibitors of CDK9. ABSTRACT Cyclin-dependent kinase 9 (CDK9) is considered as an important target in the research of antitumor drugs. Taking the CDK2/9 inhibitor CYC065 as the positive control and an in-house library compound ( 64 ) as the lead compound, four classes of 22 target compounds with 9H purine as the core structure were designed to establish

Research 100
article thumbnail

Atalanta banks $97M to send RNAi drugs into the brain

BioPharma Drive: Drug Pricing

The startup says its specially constructed RNAi therapies can get deep into brain tissue, yielding new ways to treat neurological conditions like Huntington’s.

Therapies 328
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

How To Create High Availability Kubernetes Cluster on AWS using KubeOne: Part 1

Perficient: Drug Development

Part 1 of this new blog series will focus on what KubeOne is, its features, and its architecture. KubeOne aims to provide a reliable and automated solution for provisioning, managing, and scaling Kubernetes clusters. It focuses on high availability, self-healing, and ease of maintenance across multiple nodes and environments. What is KubeOne? KubeOne is an open-source tool for setting up, managing, and scaling Kubernetes clusters in environments such as public clouds, private clouds, and on-prem

article thumbnail

FDA Approves Journavx, First New Non-Opioid Pain Pill in Decades

Drugs.com

FRIDAY, Jan. 31, 2025 -- The U.S. Food and Drug Administration (FDA) has approved Journavx, a new pain reliever without the risks of addiction or overdose linked to drugs like Vicodin and OxyContin. The new pill, developed by Vertex.

article thumbnail

Design, Synthesis, and Biological Evaluation of Aryl Pyrazolopyrimidines as Toll‐Like Receptor 7 Agonists

Chemical Biology and Drug Design

A pyrazolopyrimidine, 2-((4-methoxyphenyl)amino)-7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile exhibits TLR7 agonistic activity and stimulates an innate immune response in RAW264.7 macrophages. ABSTRACT Compounds containing pyrazolopyrimidine scaffolds were designed and synthesized as toll-like receptor 7 (TLR7) agonists. Thirty-three compounds, including 22 novel compounds, were prepared, and their structures were identified using nuclear magnetic resonance spectroscopy and mass spec

article thumbnail

A new, non-opioid pain drug is here. Getting it to patients could be agony.

BioPharma Drive: Drug Pricing

After decades of research, Vertex Pharmaceuticals now has an approved pain medication. Can one of the world’s most powerful biotechs contend with a healthcare system that’s long favored opioids?

article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

CI-CD Deployment On AWS EKS by GitHub Actions

Perficient: Drug Development

GitHub Actions is an open-source CI-CD tool that is an extended feature of GitHub. It automates software workflows with world-class CI-CD. Build, Test, and deploy your code from GitHub. How GitHub Actions Work Workflows : Workflows are automated processes defined in the YAML file and triggered on an event like Push. Events : Events are operations that change the repository, like Pull Operations and Push Operations.

52
article thumbnail

Global sea level very likely to rise between 0.5 and 1.9 meters by 2100 under high-emissions scenario

Science Daily: Pharmacology News

An interdisciplinary team of researchers has projected that if the rate of global CO2 emissions continues to increase and reaches a high emission scenario, sea levels would as a result very likely rise between 0.5 and 1.9 meters by 2100. The high end of this projection's range is 90 centimeters higher than the latest United Nations' global projection of 0.6 to 1.0 meters.

Research 298
article thumbnail

FDA OK's Ozempic To Protect Kidneys in Type 2 Diabetes Patients

Drugs.com

WEDNESDAY, Jan. 29, 2025 -- A popular diabetes drug just got a major new approval -- and it could be a game-changer for millions of Americans at risk for kidney failure. The U.S. Food and Drug Administration (FDA) has officially approved Ozempic to.

FDA 293
article thumbnail

Enhertu, with new FDA OK, set to supplant chemo in HER2-low breast cancer

BioPharma Drive: Drug Pricing

The clearance is a step forward in AstraZeneca and Daiichi Sankyo’s plan to position antibody-drug conjugates like Enhertu ahead of chemotherapy in a variety of tumors.

FDA 306
article thumbnail

Down Syndrome Diagnosis Network to Receive $5,000 Through Perficient Gives Global Grants Program

Perficient: Drug Development

Our colleagues at Perficient are generous, kind, and take pride in paying it forward through a passion for philanthropy. In 2024, Perficients Giving Employee Resource Group (ERG) launched the Perficient Gives Global Grants Program, a unique opportunity to support global nonprofit organizations in their mission to make a significant impact in our communities.

article thumbnail

The big chill: Is cold-water immersion good for our health?

Science Daily: Pharmacology News

In a comprehensive systematic review and meta-analysis, researchers have taken a deep dive into the effects of cold-water immersion on health and wellbeing. Analyzing data from 11 studies with 3177 participants, researchers found that cold-water immersion may lower stress, improve sleep quality, and boost quality of life.

Research 290
article thumbnail

Kansas Reports Largest Tuberculosis Outbreak in U.S. History

Drugs.com

TUESDAY, Jan. 28, 2025 -- Kansas health officials are fighting the largest tuberculosis (TB) outbreak in U.S. history, with 67 confirmed cases since new year began.The outbreak includes 60 active cases in Wyandotte County and seven in Johnson.

273
273
article thumbnail

FDA clears use of Ozempic to protect kidney health

BioPharma Drive: Drug Pricing

The approval adds a new indication for GLP-1 drugs and gives Novo an advantage over Lilly’s rival diabetes drug Mounjaro, which hasn’t yet proven it can improve outcomes in kidney disease.

FDA 251
article thumbnail

Sitecore Awards Six Perficient Colleagues as MVPs in 2025

Perficient: Drug Development

Were excited to share that Sitecore has honored six of our Perficient colleagues with the prestigious title of Sitecore Most Valuable Professional across all three categoriesstrategy, technology, and ambassador. With this achievement, our total MVP recognitions now exceed 80. Together, our team has continued to reach new heights and set a benchmark of excellence for our Sitecore practice here at Perficient, Art Quinn, General Manager said.

article thumbnail

Sharp look into Ockham's razor

Science Daily: Pharmacology News

A new article argues that by relying too much on parsimony in modeling, scientists make mistakes and miss opportunities.

276
276