Science Daily: Pharmacology News
JANUARY 31, 2025
Increased use of ventilation and air cleaners, designed to mitigate the spread of viral infections in hospitals, is likely to have unpredictable effects and may cause viral particles to move around more, according to a new study.
BioPharma Drive: Drug Pricing
JANUARY 30, 2025
Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.
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Drugs.com
JANUARY 31, 2025
FRIDAY, Jan. 31, 2025 -- The U.S. Food and Drug Administration (FDA) has approved Journavx, a new pain reliever without the risks of addiction or overdose linked to drugs like Vicodin and OxyContin. The new pill, developed by Vertex.
FDA Law Blog: Drug Discovery
JANUARY 30, 2025
By Mark A. Tobolowsky & Charles G. Raver & James E. Valentine We recently blogged about a new December 2024 draft guidance about accelerated approval (the December 2024 draft guidance). That post largely focused on endpoints as well as the broader context for when accelerated approval is appropriate. However, as we note in that post, the design, timing of initiation, and timely conduct of confirmatory trials are also important considerations in FDAs determination of whether accelerated
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
JANUARY 28, 2025
The study helps explain why 2023 and early 2024 saw unprecedented ocean temperatures.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
JANUARY 29, 2025
WEDNESDAY, Jan. 29, 2025 -- A popular diabetes drug just got a major new approval -- and it could be a game-changer for millions of Americans at risk for kidney failure. The U.S. Food and Drug Administration (FDA) has officially approved Ozempic to.
Chemical Biology and Drug Design
JANUARY 30, 2025
The remarkable therapeutic potential of luteolin against cervical cancer can be ascribed to its profound influence on amino acid and nucleotide metabolism, substantiated by the seamless integration of metabolomics, bioinformatics, and molecular docking techniques in this comprehensive investigation. ABSTRACT The incidence of cervical cancer is high among women globally.
Science Daily: Pharmacology News
JANUARY 27, 2025
An interdisciplinary team of researchers has projected that if the rate of global CO2 emissions continues to increase and reaches a high emission scenario, sea levels would as a result very likely rise between 0.5 and 1.9 meters by 2100. The high end of this projection's range is 90 centimeters higher than the latest United Nations' global projection of 0.6 to 1.0 meters.
BioPharma Drive: Drug Pricing
JANUARY 31, 2025
After decades of research, Vertex Pharmaceuticals now has an approved pain medication. Can one of the world’s most powerful biotechs contend with a healthcare system that’s long favored opioids?
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
JANUARY 29, 2025
WEDNESDAY, Jan. 29, 2025 -- Hidden hunger -- low levels of essential vitamins or minerals -- is common among people with type 2 diabetes, a new evidence review saysOverall, as many as 45% of type 2 diabetics are suffering multiple deficiencies in.
Chemical Biology and Drug Design
JANUARY 25, 2025
N -substituted-5-([2,5-dihydroxybenzyl]-amino)salicylamides; 1 11 , exhibited invitro anticancer activity, with Compounds 4 , 5 , and 9 being most potent. COMPARE analysis showed polypharmacological multitargeting compounds. Compounds 4 , 5 , 9 11 displayed a remarkable EGFR-TK invitro inhibitory activity, induced apoptosis in NCI-H522 cell line, and showed predicted ADME pharmacokinetic profile.
Science Daily: Pharmacology News
JANUARY 31, 2025
In a comprehensive systematic review and meta-analysis, researchers have taken a deep dive into the effects of cold-water immersion on health and wellbeing. Analyzing data from 11 studies with 3177 participants, researchers found that cold-water immersion may lower stress, improve sleep quality, and boost quality of life.
BioPharma Drive: Drug Pricing
JANUARY 28, 2025
The clearance is a step forward in AstraZeneca and Daiichi Sankyo’s plan to position antibody-drug conjugates like Enhertu ahead of chemotherapy in a variety of tumors.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JANUARY 28, 2025
TUESDAY, Jan. 28, 2025 -- Kansas health officials are fighting the largest tuberculosis (TB) outbreak in U.S. history, with 67 confirmed cases since new year began.The outbreak includes 60 active cases in Wyandotte County and seven in Johnson.
Chemical Biology and Drug Design
JANUARY 25, 2025
Coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for pancreatic lipase (PL) inhibition. Among the analogues, 5dh and 5de showed best PL inhibition, with IC 50 values of 9.20 and 11.4M, respectively, compared to Orlistat (IC 50 =0.97M). Analogue 5dh inhibited PL competitively with a K i of 4.504M. ABSTRACT A set of coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for their ability to impede pancreatic lipase (PL) activity.
Science Daily: Pharmacology News
JANUARY 31, 2025
A team of scientists has made the first experimental measurements of laser-induced motions of miniature lightsails in the lab.
BioPharma Drive: Drug Pricing
JANUARY 29, 2025
The approval adds a new indication for GLP-1 drugs and gives Novo an advantage over Lilly’s rival diabetes drug Mounjaro, which hasn’t yet proven it can improve outcomes in kidney disease.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
JANUARY 27, 2025
MONDAY, Jan. 27, 2025 -- After years of speculation, the CIA has weighed in yet again: A lab leak is now considered the likely origin of the COVID pandemic. However, the agency admits it has "low confidence" in its conclusion and says both a.
Chemical Biology and Drug Design
JANUARY 27, 2025
This study investigates the effects and mechanisms of combining Polyphyllin VII (PPVII) with Docetaxel (DTX) in the treatment of prostate cancer (Pca). Experiments were conducted using DTX-sensitive DU-145 cells and DTX-resistant DU145/DTX cells. The results indicate that PPVII significantly enhanced the inhibitory effect of DTX, reduced cell viability, and promoted apoptosis and cell cycle arrest.
Science Daily: Pharmacology News
JANUARY 31, 2025
Low levels of traffic-related air pollution harms the liver and may raise the risk of metabolic-associated fatty liver disease, a new study in mice suggests.
BioPharma Drive: Drug Pricing
JANUARY 27, 2025
Taking control of O2 — ushering in the future of cell therapy research.
Drugs.com
JANUARY 31, 2025
FRIDAY, Jan. 31, 2025 -- A rapid blood test could speed treatment for people whove suffered a stroke related to brain bleeding, a new study says.Stroke victims with brain bleeds have nearly seven times higher blood levels of a brain protein called.
Science Daily: Pharmacology News
JANUARY 30, 2025
U of T Scarborough researchers have directly linked population decline in polar bears living in Western Hudson Bay to shrinking sea ice caused by climate change.
BioPharma Drive: Drug Pricing
JANUARY 30, 2025
The testing company ended last year with $79 million and told investors it will need to raise money to fund its operations and financial commitments.
Drugs.com
JANUARY 29, 2025
WEDNESDAY, Jan. 29, 2025 -- A new strain of bird flu, H5N9, has been detected for the first time in the United States, raising concerns about how it continues to spread. The strain was discovered at a commercial duck farm in California's Merced.
Chemical Biology and Drug Design
JANUARY 30, 2025
New 9H purine derivatives were designed and synthesized, and CDK9 inhibitory activity were evaluated. Compound B5 behaved as a highly selective inhibitors of CDK9. ABSTRACT Cyclin-dependent kinase 9 (CDK9) is considered as an important target in the research of antitumor drugs. Taking the CDK2/9 inhibitor CYC065 as the positive control and an in-house library compound ( 64 ) as the lead compound, four classes of 22 target compounds with 9H purine as the core structure were designed to establish
Science Daily: Pharmacology News
JANUARY 30, 2025
The antibody targets a stable part of the bird flu virus, ensuring that the immune protection can resist new variants and offer long-term protection against the globally spreading airborne infection.
BioPharma Drive: Drug Pricing
JANUARY 30, 2025
Robert F. Kennedy Jr., nominated to be health secretary, seemed unfamiliar with the particulars of the massive insurance program he'd oversee in exchanges with senators Thursday.
Drugs.com
JANUARY 28, 2025
TUESDAY, Jan. 28, 2025 -- Helping kids with obesity drop pounds can have a huge impact on their future health.When these children and teens lose weight, they are less likely to have type 2 diabetes, high blood pressure and elevated cholesterol as.
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