Science Daily: Pharmacology News
FEBRUARY 10, 2025
Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs. This is likely down to new breeding practices introduced at the beginning of the 20th century. The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries.
Covalent Modifiers
FEBRUARY 10, 2025
DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the 14-3-3 protein family, which interacts with several hundred client proteins and plays a central role in cellular net
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Drug Target Review
FEBRUARY 10, 2025
In the rapidly advancing field of cell therapies, Dr Jason Bock has emerged as a leader, known for his innovative approach to optimising the development process. With over 25 years of experience in therapeutics, Bock has played a pivotal role in shaping the future of cell therapies, particularly through his work at CTMC. In a recent conversation, he shared his vision for transforming the development and commercialisation of novel cell therapies, focusing on cutting-edge approaches like tumour in
Codon
FEBRUARY 13, 2025
One of the ultimate aims of protein design has long been to build entirely new enzymes — proteins that perform specific chemical reactions — from scratch. These molecular machines power various cellular processes, from converting sugar into energy to switching genes on and off. Both Cas9 and hydrolases (widely used in the dairy and laundry industries) are also enzymes.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Science Daily: Pharmacology News
FEBRUARY 12, 2025
Climate scientists present a realistic supercomputer simulation that resolves the complex interactions between fire, vegetation, smoke and the atmosphere. The authors find that increasing greenhouse gas emissions will likely increase the global lightning frequency by about 1.6% per degree Celsius global warming, with regional hotspots in the eastern United States, Kenya, Uganda and Argentina.
Drug Patent Watch
FEBRUARY 10, 2025
Streamlining the Generic Drug Supply Chain: Best Practices to Improve Efficiency and Patient Access As the generic drug industry continues to grow, it's becoming increasingly clear that the traditional supply chain model is no longer sustainable. With the rise of complex generics, regulatory pressures, and increasing demand for affordable medicines, it's time to rethink the way we approach the generic drug supply chain.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Perficient: Drug Development
FEBRUARY 13, 2025
In the ever-evolving landscape of web development, choosing the right framework can significantly impact the performance and user experience of your applications. Two of the most prominent frameworks in the React ecosystem today areRemixandNext.js. Both are designed to enhance web development efficiency and performance, but they cater to different needs and use cases.
Sygnature Discovery
FEBRUARY 14, 2025
Discerning the best route to a new drug candidate can often be illuminated by building a comprehensive knowledge of a target in order to choose the best approach for a drug discovery project. Our CADD experts adopt a comprehensive target analysis approach to develop an optimal hit finding strategy and ultimately to design better, selective compounds.
addgene Blog
FEBRUARY 13, 2025
Early CRISPR applications were often limited by the low editing efficiency of homology-directed repair (HDR) , the pathway for resolving DNA double-strand breaks (DSBs) preferred by researchers. Compared to non-homologous end joining (NHEJ) , HDR occurs at a relatively low frequency, especially in nondividing cells. Scientists everywhere wistfully imagined being able to specify and correct single-base mutations without introducing DSBs at all.
Covalent Modifiers
FEBRUARY 13, 2025
Hui Tao, Bo Yang, Atena Farhangian, Ke Xu, Tongtong Li, Zhong-Yin Zhang, and Jianing Li Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02760 Covalent-allosteric inhibitors (CAIs) may achieve the best of both worlds: increased potency, long-lasting effects, and reduced drug resistance typical of covalent ligands, along with enhanced specificity and decreased toxicity inherent in allosteric modulators.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Perficient: Drug Development
FEBRUARY 12, 2025
Application programming interfaces, or APIs, are crucial to the ever-changing digital transformation landscape because they enable businesses to interact with their data and services promptly and effectively. Effective administration is therefore necessary to guarantee that these APIs operate as intended, remain secure, and offer the intended advantages.
Drug Patent Watch
FEBRUARY 12, 2025
Accelerating Generic Drug Development: Strategies for Success As a pharmaceutical professional, you know how crucial it is to navigate the complex landscape of generic drug development. With the increasing demand for affordable medications, generic drug manufacturers are under pressure to expedite their development timelines without compromising on quality.
Broad Institute
FEBRUARY 13, 2025
MPG Primer: Setting up a Biobank: Who? What? Why? By admin February 13, 2025 Breadcrumb Home MPG Primer: Setting up a Biobank: Who? What? Why? The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tools for
thought leadership
FEBRUARY 10, 2025
In today's digital age, social media has transformed how businesses communicate with their audiences. For pharmaceutical companies, this shift presents both challenges and opportunities. Social media can significantly enhance brand visibility and patient engagement and have an impact on the overall healthcare sector. Social media can significantly enhance brand visibility, patient engagement, and have an impact on the overall healthcare sector in this dynamic landscape.
Advertisement
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Perficient: Drug Development
FEBRUARY 12, 2025
The rapidly evolving payments industry is driving industry leaders to adapt their strategies in response to emerging trends. As technology advances and consumer expectations shift, staying ahead of these trends is crucial for success. Payments Trend #1: AI-Driven Payment Innovations The landscape of payments and financial services in 2025 will be marked by groundbreaking innovations and user-centric designs powered by Generative AI (GenAI).
Drug Patent Watch
FEBRUARY 11, 2025
The Dark Side of Innovation: How Companies Use Drug Patents to Block Competitors As we celebrate the breakthroughs in medical research and the development of life-saving treatments, it's essential to acknowledge the complex landscape of pharmaceutical innovation. Behind the scenes, companies are employing clever tactics to protect their intellectual property and block competitors from entering the market.
PPD
FEBRUARY 12, 2025
Its important for your clinical research organization (CRO) to continually assess and invest in capabilities that help drive the success of your clinical program. There are three core areas we are strategically addressing this year. They include: 1. Upgrading our technology stack Weve prioritized targeted improvements and new systems and tools that drive innovation, enhance efficiency, and improve site and patient relationships.
FDA Law Blog: Drug Discovery
FEBRUARY 11, 2025
By Mark A. Tobolowsky & Frank J. Sasinowski The rare pediatric disease priority review voucher program remains in its sunsetting state the current authority only allows for granting of such vouchers if the drug was designated as a drug for a rare pediatric disease not later than December 20, 2024, and for which a rare pediatric disease product application is approved not later than September 30, 2026.
Advertisement
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Sygnature Discovery
FEBRUARY 12, 2025
Sygnature Discovery has announced the appointment of Kieron Hall as its new Chief Commercial Officer (CCO) and Board member. Kieron will play a key role in driving Sygnature Discovery’s strategic vision forward. His leadership will be instrumental in steering the group towards its ambitious growth goals, and building upon the company’s strong foundation of scientific excellence and customer success.
Drug Patent Watch
FEBRUARY 13, 2025
The Unsung Heroes of Generic Drug Development: The Power of Partnerships As we navigate the complex landscape of pharmaceuticals, it's easy to overlook the crucial role that partnerships play in bringing affordable, life-saving medications to market. But the truth is, partnerships are the backbone of generic drug development, and their impact cannot be overstated.
Perficient: Drug Development
FEBRUARY 14, 2025
Looking back on our first-ever Women in Digital Breakfast at Sitecore Symposium, we had an inspiring and impactful gathering focused on empowerment, leadership, and allyship in the digital industry. The goal was to celebrate the achievements of women and provide a platform for them to share their thoughts and experiences from an industry that is constantly evolving.
FDA Law Blog: Biosimilars
FEBRUARY 13, 2025
By Lisa M. Baumhardt, Principal Medical Device Regulatory Expert FDA recently released its final guidance for Predetermined Change Control Plans (PCCPs) for Artificial Intelligence-Enabled Device Software Functions (AI-DSF). The final guidance hasnt changed much from the draft guidance with respect to the type of modifications FDA considers applicable for a PCCP and the required components of a PCCP (see our prior blog post on the draft guidance here ).
Advertisement
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
FEBRUARY 13, 2025
Electronic textiles, such as heating pads and electric blankets, can keep the wearer warm and help ease aches and pains. However, prolonged use of these devices could possibly cause heat-related illnesses, including hyperthermia or burns. Recently, a group of researchers designed and tested a 'smart' jacket equipped with environmental sensors, heat-generating and color-changing yarns, and artificial intelligence (AI) to control temperature and prevent overheating.
Drugs.com
FEBRUARY 10, 2025
MONDAY, Feb. 10, 2025 -- Yes, rare cases of vision issues have arisen in people taking popular GLP-1 weight loss drugs, but the jury's out on whether the medications caused the eye trouble, according to a new small study.The study reviewed the.
Perficient: Drug Development
FEBRUARY 11, 2025
Ensuring clear focus visibility is key for accessibility; sometimes, visually impaired users and keyboard navigators have trouble interacting with web content. This blog explores practical ways to fix focus visibility issues and improve user experience. ADA Compliance Overview ADA compliance ensures websites are accessible to people with disabilities, promoting inclusivity and fairness.
FDA Law Blog: Biosimilars
FEBRUARY 11, 2025
By Alan M. Kirschenbaum & Sophia R. Gaulkin Drug manufacturers wont be receiving their first invoices for Medicare Part B and Part D inflation rebates until later this year, but rebates have been accruing since first quarter 2023 for Part B rebates and October 2022 for Part D rebates. To help our readers learn more about these rebates before they confront the first invoices, weve prepared a memo summarizing CMS final rule on the two Medicare inflation rebate programs, which was issued on De
Science Daily: Pharmacology News
FEBRUARY 12, 2025
Global warming is producing a rapid loss of plant species -- according to estimates, roughly 600 plant species have died out since 1750 -- twice the number of animal species lost. But which species are hit hardest? And how does altered biodiversity actually affect interactions between plants? Experts have tackled these questions and, in two recent studies, presented the answers they found buried in the past: using fragments of plant genetic material (DNA) deposited in lake sediments, they were a
Drugs.com
FEBRUARY 14, 2025
FRIDAY, Feb. 14, 2025 -- There appears to be limited evidence supporting the use of epidural steroid injections for certain types of chronic lower back pain, new guidance from the American Academy of Neurology (AAN) finds. Epidural steroid.
Perficient: Drug Development
FEBRUARY 11, 2025
Optimizing B2B E-commerce with Optimizely Commerce: Best Practices and Key Features In todays fast-paced digital landscape, businesses need robust and scalable e-commerce solutions to meet the growing demands of B2B buyers. Optimizely Commerce (formerly Insite) is a leading platform that empowers businesses with cutting-edge tools to enhance the online purchasing experience.
FDA Law Blog: Biosimilars
FEBRUARY 12, 2025
By Sophia R. Gaulkin & Esther Petrikovsky & David B. Clissold On January 21, 2025, the Trump administration withdrew FDAs proposed ban on menthol cigarettes, which the Biden administration initially introduced in 2022. This move is the latest step in FDAs long, uncertain, and controversial journey to ban menthol cigarettes. For some background (which is covered in more detail in one of our previous posts on the subject ), in 2009, Congress specifically exempted tobacco or menthol when i
Science Daily: Pharmacology News
FEBRUARY 13, 2025
Who hasn't been there? The big meal is over, you're full, but the craving for sweets remains. Researchers have now discovered that what we call the 'dessert stomach' is rooted in the brain. The same nerve cells that make us feel full after a meal are also responsible for our craving for sweets afterwards.
BioPharma Drive: Drug Pricing
FEBRUARY 10, 2025
The drug is cleared to treat complicated intra-abdominal infections, including those caused by tough-to-control, gram-negative bacteria.
Expert insights. Personalized for you.
Let's personalize your content