Practical Cheminformatics
NOVEMBER 16, 2024
Introduction Dataset splitting is one topic that doesn’t get enough attention when discussing machine learning (ML) in drug discovery. The data is typically divided into training and test sets when developing and evaluating an ML model. The model is trained on the training set, and its performance is assessed on the test set. If hyperparameter tuning is required, a validation set is also included.
Science Daily: Pharmacology News
NOVEMBER 16, 2024
The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.
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BioPharma Drive: Drug Pricing
NOVEMBER 18, 2024
The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.
Covalent Modifiers
NOVEMBER 22, 2024
Giulia Alboreggia, Parima Udompholkul, Emma L. Atienza, Kendall Muzzarelli, Zahra Assar, and Maurizio Pellecchia Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.4c01541 Covalent drugs provide pharmacodynamic and pharmacokinetic advantages over reversible agents. However, covalent strategies have been developed mostly to target cysteine (Cys) residues, which are rarely found in binding sites.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Drugs.com
NOVEMBER 18, 2024
MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
Researchers have discovered evidence of the oldest alphabetic writing in human history. The writing was etched onto clay cylinders discovered during a dig at an ancient Syrian city.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Covalent Modifiers
NOVEMBER 18, 2024
Conghao Gai, Hairong Zeng , Haoming Xu, Xiaoyun Chai, Yan Zou, Chunlin Zhuang, Guangbo Ge, Qingjie Zhao European Journal of Medicinal Chemistry, 2024 [link] Isocitrate dehydrogenase (IDH) is an enzyme that catalyses the oxidative decarboxylation of isocitrate, producing α-ketoglutarate (α-KG) relative to the hydroxylation of substrates. However, IDH mutants can further reduce α-KG to 2-hydroxyglutarate (2-HG) which competitively inhibits α-KG dependent enzymes, leading to the downregulation of n
Drugs.com
NOVEMBER 20, 2024
WEDNESDAY, Nov. 20, 2024 -- Rates of postpartum depression have more than doubled in little over a decade among American women, a new analysis shows. While about 1 in every 10 new moms (9.4%) suffered postpartum depression in 2010, that number rose.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
Scientists discovered a stretch of DNA in both C3 plants, like wheat and soybeans, and C4 plants, like corn and sorghum, that is responsible for optimizing C4 plant photosynthesis and making them better at withstanding heat and drought. The findings are insightful in understanding how some plants evolved to be more efficient, and may now be used as a springboard for turning C4 photosynthesis on in C3 plants -- an important step for creating sustainable crop populations in the face of climate cha
BioPharma Drive: Drug Pricing
NOVEMBER 22, 2024
The approval of Attruby for transthyretin amyloidosis with cardiomyopathy begins a battle for control of a lucrative market that investors have been skeptical BridgeBio can win.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Collaborative Drug
NOVEMBER 18, 2024
Vault Snack #25 - All About CDD Vault Templates
Drugs.com
NOVEMBER 19, 2024
TUESDAY, Nov. 19, 2024 -- Women who won't leave the house without makeup or a spritz of hairspray may want to think twice about those habits when they're pregnant or breastfeeding.New research links these and other personal care products, including.
Science Daily: Pharmacology News
NOVEMBER 22, 2024
New research has uncovered what may be the oldest direct evidence of ancient hot water activity on Mars, revealing the planet may have been habitable at some point in its past.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
The startup, Pep2Tango, is combining four methods of accelerating weight loss into one medicine in the hopes of developing a treatment that can improve upon drugs like Wegovy and Zepbound.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Perficient: Drug Development
NOVEMBER 20, 2024
Quantum computing is rapidly transitioning from theory to reality, using the principles of quantum mechanics to achieve computational power far beyond traditional computers. Imagine upgrading from a bicycle to a spaceship—quantum computers can solve complex problems at extraordinary speeds. However, this leap in computing power poses significant challenges, particularly for cybersecurity, which forms the backbone of data protection in our digital world.
Drugs.com
NOVEMBER 22, 2024
FRIDAY, Nov. 22, 2024 -- America's kitchen trash bins are receiving more unwanted food as appetites falter among people taking GLP-1 weight-loss meds, a new study shows.GLP-1s like Ozempic, Wegovy, Mounjaro and Zepbound all work by making food less.
Science Daily: Pharmacology News
NOVEMBER 21, 2024
Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.
BioPharma Drive: Drug Pricing
NOVEMBER 18, 2024
Phase 1 data indicate Intellia’s medicine could be a powerful treatment for a cardiac form of ATTR amyloidosis. But rival drugs are further ahead.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Collaborative Drug
NOVEMBER 19, 2024
Drug Discovery Industry Roundup with Barry Bunin — November, 6 2024
Drugs.com
NOVEMBER 22, 2024
FRIDAY, Nov. 22, 2024 -- A daily dose of vitamin B3 reduced inflammation in the lungs of patients with COPD, Danish researchers report. "This is significant, because inflammation can lead to reduced lung function in these patients," said researcher.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
A recently published meta-analysis reveals an advantage in sports-related information processing compared to non-athletes. The data consisted of 21 studies involving a total of 1455 participants. Athletes had better working memory than non-athletes and this advantage was further enhanced when athletes were compared to sedentary people.
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2024
Pfizer will work with Ampersand Biomedicines and Montai Therapeutics to find drugs for obesity and lung cancer, respectively, adding to collaborations it previously formed with other Flagship startups.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Chemical Biology and Drug Design
NOVEMBER 21, 2024
Edaravone significantly lowered glucose, leptin, insulin, apolipoprotein-B, body weight, weight gain, food, and water intake in rats. The intervention significantly reduced heart rate, systolic, diastolic, and mean diastolic blood pressure. The lipid profile, antioxidant levels, inflammatory cytokines, and MMP levels were also affected in atherosclerotic rats.
Drugs.com
NOVEMBER 21, 2024
THURSDAY, Nov. 21, 2024 -- A wearable patch the size of a postage stamp that can monitor blood pressure continuously could soon help people manage their hypertension.Researchers at the University of California, San Diego, who developed the wearable.
Science Daily: Pharmacology News
NOVEMBER 20, 2024
Trust between humans and robots is improved when the movement between both is harmonized, researchers have discovered.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2024
Venture capital firms incubate, grow and finance dozens of new drug companies each year. Follow the money they channel into the industry with this database.
Nvidia Developer: Drug Discovery
NOVEMBER 18, 2024
AI models for science are often trained to make predictions about the workings of nature, such as predicting the structure of a biomolecule or the properties of. AI models for science are often trained to make predictions about the workings of nature, such as predicting the structure of a biomolecule or the properties of a new solid that can become the next battery material.
Drugs.com
NOVEMBER 18, 2024
MONDAY, Nov. 18, 2024 -- People on blood thinners have a doubled risk of dangerous internal bleeding if they also take a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen, a new study warns.People typically are prescribed.
Science Daily: Pharmacology News
NOVEMBER 21, 2024
A massive collision of galaxies sparked by one travelling at a scarcely-believable 2 million mph (3.2 million km/h) has been seen in unprecedented detail by one of Earth's most powerful telescopes. The dramatic impact was observed in Stephan's Quintet, a nearby galaxy group made up of five galaxies first sighted almost 150 years ago. It sparked an immensely powerful shock akin to a 'sonic boom from a jet fighter' -- the likes of which are among the most striking phenomena in the Universe.
BioPharma Drive: Drug Pricing
NOVEMBER 22, 2024
The restructuring follows the company's receipt of a letter from the FDA citing "deficiencies" in its approval application for diabetes drug Zynquista.
Drug Patent Watch
NOVEMBER 18, 2024
The concept of a blockbuster drug, defined as a medication generating at least $1 billion in annual sales, has long been a cornerstone of the pharmaceutical industry. However, the question arises whether a drug can achieve blockbuster status without heavily relying on U.S. sales.
Drugs.com
NOVEMBER 21, 2024
THURSDAY, Nov. 21, 2024 -- After a hit to the head or a fall, people, especially seniors, can develop a dangerous pooling of blood and fluid between the brain's surface and it's protective covering, the dura.These "subdural hematomas" typically.
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