Sat.Nov 16, 2024 - Fri.Nov 22, 2024

article thumbnail

Some Thoughts on Splitting Chemical Datasets

Practical Cheminformatics

Introduction Dataset splitting is one topic that doesn’t get enough attention when discussing machine learning (ML) in drug discovery. The data is typically divided into training and test sets when developing and evaluating an ML model. The model is trained on the training set, and its performance is assessed on the test set. If hyperparameter tuning is required, a validation set is also included.

article thumbnail

Multiclass Text Classification Using LLM (MTC-LLM): A Comprehensive Guide

Perficient: Drug Development

Introduction to Multiclass Text Classification with LLMs Multiclass text classification (MTC) is a natural language processing (NLP) task where text is categorized into multiple predefined categories or classes. Traditional approaches rely on training machine learning models, requiring labeled data and iterative fine-tuning. However, with the advent of large language models (LLMs), this task can now be approached differently.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

How Can High Content Imaging Transform Your Cancer Research?

Crown Bioscience

The field of oncology research demands innovative, multi-dimensional approaches to tackle the complexities of cancer biology, therapeutic responses, and immune interactions. High Content Imaging (HCI) is revolutionizing this space, combining automated microscopy, advanced imaging, and data analytics to provide unparalleled insights into cellular behaviors.

article thumbnail

Researchers identify source of a brain cancer’s deadly transformation

Broad Institute

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations. By Wynne Parry November 21, 2024 Credit: Castro Lab, Michigan Medicine, Ann Arbor Glioma tumor cells seen under a microscope Related news Targeted drug treatment leads tumor cells to imitate vir

article thumbnail

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

article thumbnail

AI in Pharma: Benefits, Risks and the Road Ahead

Fierce BioTech

AI in Pharma: Benefits, Risks and the Road Ahead AI is revolutionizing the drug development process, streamlining and accelerating every stage, from research to approval and marketing. This whitepaper explores the benefits and risks of AI in the pharmaceutical industry and examines its future. jkarimi Fri, 11/22/2024 - 15:01 AI is revolutionizing the drug development process, streamlining and accelerating every stage, from research to approval and marketing.

article thumbnail

Quantum Computing and Cybersecurity: Preparing for a Quantum-Safe Future

Perficient: Drug Development

Quantum computing is rapidly transitioning from theory to reality, using the principles of quantum mechanics to achieve computational power far beyond traditional computers. Imagine upgrading from a bicycle to a spaceship—quantum computers can solve complex problems at extraordinary speeds. However, this leap in computing power poses significant challenges, particularly for cybersecurity, which forms the backbone of data protection in our digital world.

More Trending

article thumbnail

Accelerate Drug and Material Discovery with New Math Library NVIDIA cuEquivariance

Nvidia Developer: Drug Discovery

AI models for science are often trained to make predictions about the workings of nature, such as predicting the structure of a biomolecule or the properties of. AI models for science are often trained to make predictions about the workings of nature, such as predicting the structure of a biomolecule or the properties of a new solid that can become the next battery material.

article thumbnail

Comprehensive Exploration of Isocitrate Dehydrogenase (IDH) Mutations: Tumorigenesis, Drug Discovery, and Covalent Inhibitor Advances

Covalent Modifiers

Conghao Gai, Hairong Zeng , Haoming Xu, Xiaoyun Chai, Yan Zou, Chunlin Zhuang, Guangbo Ge, Qingjie Zhao European Journal of Medicinal Chemistry, 2024 [link] Isocitrate dehydrogenase (IDH) is an enzyme that catalyses the oxidative decarboxylation of isocitrate, producing α-ketoglutarate (α-KG) relative to the hydroxylation of substrates. However, IDH mutants can further reduce α-KG to 2-hydroxyglutarate (2-HG) which competitively inhibits α-KG dependent enzymes, leading to the downregulation of n

article thumbnail

Edaravone Ameliorate Inflammation in Vitamin D3 and High Fat Diet Induced Atherosclerosis in Rat via Alteration of Inflammatory Pathway and Gut Microbiota

Chemical Biology and Drug Design

Edaravone significantly lowered glucose, leptin, insulin, apolipoprotein-B, body weight, weight gain, food, and water intake in rats. The intervention significantly reduced heart rate, systolic, diastolic, and mean diastolic blood pressure. The lipid profile, antioxidant levels, inflammatory cytokines, and MMP levels were also affected in atherosclerotic rats.

article thumbnail

Can drugs be blockbusters without relying on US sales?

Drug Patent Watch

The concept of a blockbuster drug, defined as a medication generating at least $1 billion in annual sales, has long been a cornerstone of the pharmaceutical industry. However, the question arises whether a drug can achieve blockbuster status without heavily relying on U.S. sales.

article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

GAO Report Recommends Retaining FDA’s Drug Inspectional Workforce As Agency Prepares for Trumpian Changes

FDA Law Blog: Biosimilars

By John W.M. Claud & Mark I. Schwartz — Over the past few days, we’ve been blogging about changes that are sure to come to FDA under Trump 2.0. Calls to more generally gut Federal agencies are everywhere, including from Robert F. Kennedy, Jr., the current nominee to lead the department of Health and Human Services. But shedding regulators in sensitive areas like drug manufacturing—even in the era of influencer-driven medicine—can lead to compromises in safety and efficacy, especially when FD

FDA
article thumbnail

Covalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 Mimetics

Covalent Modifiers

Giulia Alboreggia, Parima Udompholkul, Emma L. Atienza, Kendall Muzzarelli, Zahra Assar, and Maurizio Pellecchia Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.4c01541 Covalent drugs provide pharmacodynamic and pharmacokinetic advantages over reversible agents. However, covalent strategies have been developed mostly to target cysteine (Cys) residues, which are rarely found in binding sites.

article thumbnail

How Does Imaging Support the Development of New Therapeutics

Fierce BioTech

How Does Imaging Support the Development of New Therapeutics Antibody-drug conjugates (ADCs) and radioisotope therapies (RITs) offer targeted therapies that effectively attack tumor cells while minimizing harm to surrounding healthy tissue. However, getting the design of ADC and RIT trials right is critical. This resource explores the pivotal role advanced medical imaging plays in improving clinical trial design and patient access to cutting-edge treatment options. tharilall Sun, 11/17/2024 - 13

article thumbnail

Superior photosynthesis abilities of some plants could hold key to climate-resilient crops

Science Daily: Pharmacology News

Scientists discovered a stretch of DNA in both C3 plants, like wheat and soybeans, and C4 plants, like corn and sorghum, that is responsible for optimizing C4 plant photosynthesis and making them better at withstanding heat and drought. The findings are insightful in understanding how some plants evolved to be more efficient, and may now be used as a springboard for turning C4 photosynthesis on in C3 plants -- an important step for creating sustainable crop populations in the face of climate cha

DNA
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Evidence v. Belief: What a Kennedy Appointment Could Mean to FDA and Public Health

FDA Law Blog: Biosimilars

By Jennifer D. Newberger & Jeffrey N. Gibbs — On Thursday, November 14, President-Elect Trump announced his pick of Robert Kennedy, Jr., for Secretary of Health and Human Services (HHS). Although not altogether surprising, the formality of an official announcement still came as a shock to many of us who work in areas regulated by HHS, as well as to many others in the public health arena.

FDA
article thumbnail

The Future of Generic Drug Development in Emerging Markets

Drug Patent Watch

The pharmaceutical industry is undergoing a significant shift, with emerging markets offering the next growth opportunity. This growth is driven by several factors, including the increasing prevalence of chronic diseases, cost-effectiveness, and patent expirations of branded drugs.

article thumbnail

SAP and Databricks: Better Together

Perficient: Drug Development

Across industries like manufacturing, energy, life sciences, and retail, data drives decisions on durability, resilience, and sustainability. A significant share of this critical data resides in SAP systems , which is why so many business have invested i SAP Datasphere. SAP Datasphere is a comprehensive data service that enables seamless access to mission-critical business data across SAP and non-SAP systems.

article thumbnail

NASA satellites reveal abrupt drop in global freshwater levels

Science Daily: Pharmacology News

The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.

article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Even in “Unprecedented” Times, There is Precedent

FDA Law Blog: Biosimilars

By JP Ellison — The word unprecedented has been used a lot in the past two weeks. Perhaps appropriately. Below is some precedent that’s been on this blogger’s mind recently and that may be relevant in the coming days, weeks, and months: Tummino v. Hamburg. Why? The HHS Secretary intervened in an FDA approval decision. The court ruled the agency’s action was arbitrary and capricious and entered a mandatory injunction ordering FDA to make the drug available.

article thumbnail

CDMO Vendor Management: Best Practices

Drug Patent Watch

The pharmaceutical industry has increasingly turned to contract development and manufacturing organizations (CDMOs) to optimize their facilities and outsource non-core production. Effective CDMO vendor management is crucial for the success of these partnerships. Here, we outline best practices for selecting, qualifying, and managing CDMOs.

article thumbnail

AI Regulations for Financial Services: Japan

Perficient: Drug Development

Artificial intelligence (AI) is poised to affect every aspect of the world economy and play a significant role in the global financial system, leading financial regulators around the world to take various steps to address the impact of AI on their areas of responsibility. The economic risks of AI to the financial systems include everything from the potential for consumer and institutional fraud to algorithmic discrimination and AI-enabled cybersecurity risks.

article thumbnail

Oldest known alphabet unearthed in ancient Syrian city

Science Daily: Pharmacology News

Researchers have discovered evidence of the oldest alphabetic writing in human history. The writing was etched onto clay cylinders discovered during a dig at an ancient Syrian city.

article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

FDA endorses speedy approval path for Regenxbio Duchenne gene therapy

BioPharma Drive: Drug Pricing

The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.

article thumbnail

The Future of Partnerships in Generic Drug Development

Drug Patent Watch

The pharmaceutical industry is undergoing significant transformations, particularly in the realm of generic drug development. Recent trends and advancements in technology, research, and collaboration are reshaping the landscape of generic drug development, leading to new opportunities and challenges for pharmaceutical companies.

article thumbnail

Data protection and fail safe in snowflake

Perficient: Drug Development

Problem statement: It is not uncommon to accidentally execute statements that update or delete incorrect data in database tables. To address this, Snowflake offers a feature known as Fail-safe , which allows for the recovery of lost or altered data. This functionality provides a way to restore data that may have been mistakenly updated or deleted. Below, we outline several examples and methods for recovering data using Snowflake’s Fail-safe feature.

article thumbnail

Ancient hot water on Mars points to habitable past

Science Daily: Pharmacology News

New research has uncovered what may be the oldest direct evidence of ancient hot water activity on Mars, revealing the planet may have been habitable at some point in its past.

article thumbnail

Diabetes Meds Metformin, GLP-1s Can Also Curb Asthma

Drugs.com

MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.

article thumbnail

Amgen picks prolific biotech founder Chang as new top scientist

BioPharma Drive: Drug Pricing

Howard Chang will take over as chief scientific officer and senior VP of research as the biotech searches for more ways to overcome the looming loss of exclusivity for some of its top-selling medicines.

article thumbnail

Vault Snack #25 - All About CDD Vault Templates

Collaborative Drug

Vault Snack #25 - All About CDD Vault Templates

article thumbnail

Researchers identify previously unknown compound in drinking water

Science Daily: Pharmacology News

Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.

article thumbnail

U.S. Postpartum Depression Diagnoses Doubled in a Decade

Drugs.com

WEDNESDAY, Nov. 20, 2024 -- Rates of postpartum depression have more than doubled in little over a decade among American women, a new analysis shows. While about 1 in every 10 new moms (9.4%) suffered postpartum depression in 2010, that number rose.

article thumbnail

BridgeBio heart drug approved by FDA, setting up battle with Pfizer

BioPharma Drive: Drug Pricing

The approval of Attruby for transthyretin amyloidosis with cardiomyopathy begins a battle for control of a lucrative market that investors have been skeptical BridgeBio can win.

FDA