Drug Target Review

DECEMBER 20, 2024

Artificial intelligence (AI) has revolutionised many industries, yet its adoption in pharmaceutical drug development has been notably slower. Concerns surrounding data security, the complexity of AI systems, and the rigorous regulatory frameworks in this field have caused the pharmaceutical industry to approach these technologies with caution. For years, AI and machine learning (ML) were often dismissed as little more than advanced statistics with little practical value in drug development.

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Clinical Trials Trials Pharmaceuticals Drug Development 128

keypoint

DECEMBER 20, 2024

Meet the Keystone Symposia Fellows Class of 2025, a stellar group of post-doctoral fellows and early-career scientists who will take part in this prestigious mentorship program.

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Doctors 123

Science Daily: Pharmacology News

DECEMBER 20, 2024

Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.

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BioPharma Drive: Drug Pricing

DECEMBER 20, 2024

Novo shares lost nearly a quarter of their value after an experimental combination treatment called cagrisema fell short of the bar set by executives.

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Trials Treatment Drugs 117

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- An existing drug might be able to treat an autoimmune disorder that causes dry eye, dry mouth, fatigue and muscle or joint pain. Baricitinib (Olumiant), a drug currently used to treat rheumatoid arthritis, appears to.

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Disease Research Drugs 116

Chemical Biology and Drug Design

DECEMBER 20, 2024

Our results demonstrate the effects of LYD on cell viability, cell cycle, and apoptosis in NSCLC invitro and invivo models and explored its underlying mechanisms. Our findings suggest that LYD inhibited NSCLC cells growth by inducing G2/M arrest and subsequent apoptosis. It also inhibited the P70S6K and PS6 pathways. More interestingly, LYD also significantly activated the STING pathway in NSCLC, inducing CXCL10 and CCL5 expression, which may help overcome immunotherapy resistance.

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Immune Response Treatment Research 100

BioPharma Drive: Drug Pricing

DECEMBER 19, 2024

The FDA’s decision will close a lucrative market opportunity for compounding pharmacies, although the agency will give a limited grace period before taking any enforcement actions.

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Compounding Pharmacies FDA Pharmacy Marketing 111

Drugs.com

DECEMBER 16, 2024

MONDAY, Dec. 16, 2024 -- The established hormone therapy drug tamoxifen can significantly decrease the risk of cancer recurring in women with an early, low-risk form of breast cancer, a new study says. Women who took tamoxifen after undergoing a.

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Therapies Drugs 111

Chemical Biology and Drug Design

DECEMBER 19, 2024

The new palmitoylated derivatives of thioglycolic acid are designed to mimic microbial lipopeptides as a new class of small-molecule immunomodulators. The most active compound ( 10 ) induced a 1226-fold increase in the expression of TNF- and IL-1 mRNA and triggered a marked release of NO in isolated macrophages at 1.0M. ABSTRACT The immune system is essential for the defense against infections and is critically implicated in various disorders, including immunodeficiency, autoimmunity, inflammati

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Small Molecule Immune Response Research 100

Science Daily: Pharmacology News

DECEMBER 18, 2024

California ground squirrels hunt, kill and eat voles, reveals a new study documenting evidence of widespread carnivorous behavior among squirrels.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

DECEMBER 16, 2024

The company is scrapping two drugs aimed at targets called TIGIT and LAG-3, both of which were in the middle of Phase 3 testing.

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Drugs 111

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- An outbreak of salmonella linked to cucumbers has now been tied to 100 known cases of the illness across 23 states, the U.S. Food and Drug Administration reported Thursday. That's up from 68 cases reported in the FDA's last.

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FDA Drugs 105

Chemical Biology and Drug Design

DECEMBER 19, 2024

The results of invivo anti-inflammatory tests showed that compound 5k was the most potent of the mollugin derivatives with an inhibition rate of 81.77%, which was significantly more potent than or the positive control drugs (ibuprofen and mesalazine). ABSTRACT Nuclear factor B (NF-B) is a key inducible transcription factor that controls a large number of genes involved in inflammatory and immune processes.

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Pharmacokinetics Regulations Treatment Drugs 100

Science Daily: Pharmacology News

DECEMBER 19, 2024

A brotherly research duo has discovered that when the Large Hadron Collider (LHC) produces top quarks -- the heaviest known fundamental particles -- it regularly creates a property known as magic.

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Research 114

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

DECEMBER 17, 2024

Phase 2 results in inflammatory bowel disease hinted the therapy could be more potent than similar medicines from Merck and Roche, each of which were acquired in multibillion-dollar deals.

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Disease Therapies Drugs 107

Drugs.com

DECEMBER 19, 2024

THURSDAY, Dec. 19, 2024 -- Parkinson's is a relentless disease for which few treatments, and no real cure, exists. Now, researchers say they are on the trail of a potential new therapy for the disabling neurological illness.It's early research.

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Research Therapies Treatment Disease 105

Quanticate

DECEMBER 16, 2024

A randomised controlled clinical trial is the most prevalent design used in Phase II and Phase III clinical trials, whereby participants are randomly assigned to a control or experimental group with a fixed probability, normally 50% for each treatment. This is the gold standard [1] for identifying the best treatment within the trial with a large degree of certainty [2].

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Clinical Trials Trials Disease Treatment 97

Science Daily: Pharmacology News

DECEMBER 19, 2024

Opening new doors for the development of nanotechnologies in medicine and other fields, scientists recreate and compare two natural mechanisms to better program the timescale of molecular communication and functionality.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

DECEMBER 19, 2024

Even with another mid-stage setback, Roche believes there were enough positive signs to “merit further exploration” of the drug, which it’s been developing with Prothena for more than a decade.

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Drugs 103

Drugs.com

DECEMBER 18, 2024

WEDNESDAY, Dec. 18, 2024 -- In a case first reported in Louisiana last Friday, a patient has now developed the first known case of bird flu so severe as to require hospitalization, according to the U.S. Centers for Disease Control and Prevention.

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Hospitals Disease 105

Drug Patent Watch

DECEMBER 17, 2024

Flexibility has become more than just a buzzword it’s a necessity. Contract Development and Manufacturing Organizations (CDMOs) are at the forefront of this shift, playing a crucial role in bringing innovative therapies to market. But what exactly makes flexibility so important for CDMOs, and how can they cultivate this essential trait? Let’s dive into the world of pharmaceutical outsourcing and explore why adaptability is the key to success.

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Pharmaceuticals Therapies Production Pharmaceutical Companies 90

Science Daily: Pharmacology News

DECEMBER 18, 2024

While volcanism caused a temporary cold period, the effects had already worn off thousands of years before the meteorite, the ultimate cause of the dinosaur extinction event, impacted.

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BioPharma Drive: Drug Pricing

DECEMBER 18, 2024

“Pain has really been out of favor in the industry up until very recently,” said John Mulcahy, SiteOne Therapeutics’ CEO. The company plans to use its new funds to get to “proof of concept” for its medicines.

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Drugs 103

Drugs.com

DECEMBER 19, 2024

THURSDAY, Dec. 19, 2024 -- California Gov. Gavin Newsom declared a public health emergency on Wednesday as bird flu continues to spread among the states dairy cattle.This proclamation is a targeted action to ensure government agencies have the res.

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Government 105

Advarra

DECEMBER 17, 2024

2024 has been a year of growth and evolution in clinical research. The coming year is expected to be no different. As we look to 2025, Advarra thought leaders have compiled predictions and perspectives on key topics shaping the industry. These topics include perspectives on how artificial intelligence (AI) will be leveraged in clinical research, key regulatory trends shaping the industry, the movements of site consolidation, the continued challenges (and potential solutions) of study startup, an

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Clinical Research Clinical Trials Trials Hospitals 98

Science Daily: Pharmacology News

DECEMBER 19, 2024

Antibodies can improve the rehabilitation of people with acute spinal cord injury. Researchers have investigated this with promising results. For the first time, it was possible to identify patient groups that displayed a clinically relevant treatment effect.

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Treatment Research 113

BioPharma Drive: Drug Pricing

DECEMBER 17, 2024

An FDA approval of Merck’s drug clesrovimab by June would give physicians another option for protecting newborns from respiratory syncytial virus.

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FDA FDA Approval Virus Drugs 94

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- Sexism is incredibly toxic to womens lives, resulting in lower pay, fewer career opportunities, worse health care and a greater risk of violence.It also can be toxic to their brain health, a new study says.U.S. women born i.

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keypoint

DECEMBER 20, 2024

Keystone Symposia CEO shares his first impressions, improvement and initiatives that will be implemented in 2025.

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Science Daily: Pharmacology News

DECEMBER 20, 2024

Scientists have discovered a way to remove toxic compounds from potatoes and tomatoes, making them safer to eat and easier to store. The breakthrough could cut food waste and enhance crop farming in extreme environments, like outer space.

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Drug Patent Watch

DECEMBER 18, 2024

Protecting your intellectual property is paramount. Drug patent prosecution is a complex and critical process that can make or break the success of a new medication. As a business professional in the pharmaceutical industry, understanding and implementing effective strategies for drug patent prosecution can be the difference between market domination and missed opportunities.

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Pharmaceuticals Drugs Drug Development Pharmaceutical Companies 98

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- Holy chip! Frito-Lay has issued a limited recall of select 13-oz bags of Lays Classic Potato Chips due to the potential presence of undeclared milk, which could pose a serious health risk to individuals with a milk a.

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keypoint

DECEMBER 20, 2024

Checkout the December 2024 Keypoint Newsletter for the latest news and views from Keystone Symposia, including Fellows spotlights, our new partership with the Endocrine Society, Women in Science networking events, emerging topics conferences and conference highlights.

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Science 82