Sat.Mar 16, 2024 - Fri.Mar 22, 2024

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DDW Spring 2024

Drug Discovery World

The DDW Spring issue looks at where we are in the fight against antimicrobial resistance, explores how structural biology is informing vaccine design, and offers advice on approaching dealmaking in biopharma. It also includes an exclusive cell and gene therapy guide examining the innovation happening in this sector. DDW SPRING 2024 The post DDW Spring 2024 appeared first on Drug Discovery World (DDW).

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8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death

Science Daily: Pharmacology News

A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease.

Disease 141
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Spatial study of lung cancer reveals immune markers of response to immunotherapy

Broad Institute

Spatial study of lung cancer reveals immune markers of response to immunotherapy By Corie Lok March 20, 2024 Breadcrumb Home Spatial study of lung cancer reveals immune markers of response to immunotherapy Researchers visualize how immune cells are spatially organized within tumors and show that certain immune “hubs” are linked to better treatment responses.

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FDA clears first-of-its-kind Duchenne drug for broad use

BioPharma Drive: Drug Pricing

The approval of Italfarmaco’s Duvyzat is the first for an oral, non-steroidal Duchenne drug and was issued for all patients at least six years of age, regardless of their genetic underpinnings.

FDA 120
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Is Recursion’s new London hub an epicentre of drug discovery?

Drug Discovery World

Recursion has announced plans to open a new office in June 2024. The site will provide Recursion and Valence Labs, the company’s artificial intelligence (AI) research engine, with access to European talent and a life science ecosystem from which to work. Chris Gibson, Co-founder and CEO at Recursion, said: “London stood out as an ideal location given its brilliant and interdisciplinary talent across the fields of technology, biology and chemistry.

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James Webb Space Telescope captures the end of planet formation

Science Daily: Pharmacology News

How much time do planets have to form from a swirling disk of gas and dust around a star? A new study gives scientists a better idea of how our own solar system came to be.

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Clasp launches with $150M and a plan for precision cancer immunotherapies

BioPharma Drive: Drug Pricing

The company claims its approach could yield more effective and safer T-cell engagers, a type of cancer medicine that’s attracted significant interest from drugmakers in recent years.

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Meet the Researcher: Elaine Duncan, University of Glasgow

Drug Discovery World

DDW’s Diana Spencer speaks to Elaine Duncan, a PhD student on the lifETIME (Engineered Tissues for Discovery, Industry and Medicine) CDT at the University of Glasgow. DS: Can you tell us what you do and what you’re working on at the moment? ED : I’m currently a PhD researcher at the University of Glasgow. My research is focused on developing a 3D in vitro model of adipose tissue which can be used in the lab to help us better understand the complex signalling pathways of metabolic disorders and h

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Two artificial intelligences talk to each other

Science Daily: Pharmacology News

Performing a new task based solely on verbal or written instructions, and then describing it to others so that they can reproduce it, is a cornerstone of human communication that still resists artificial intelligence (AI). A team has succeeded in modelling an artificial neural network capable of this cognitive prowess. After learning and performing a series of basic tasks, this AI was able to provide a linguistic description of them to a 'sister' AI, which in turn performed them.

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Medicare to Cover Wegovy When Patients Also Have Heart Disease

Drugs.com

FRIDAY, March 22, 2024 -- Medicare will now cover the popular weight-loss drug Wegovy if patients using it also have heart disease, U.S. officials announced Thursday.The move comes after the U.S. Food and Drug Administration approved drugmaker Novo.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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NextCure to lay off 37% of staff, dial back research plans

BioPharma Drive: Drug Pricing

The job cuts at the cancer drug developer will primarily impact manufacturing roles, but will touch on several other parts of the organization, the company said.

Research 114
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This week in drug discovery (18-22 March) 

Drug Discovery World

News round-up for 18-22 March by DDW Digital Content Editor Diana Spencer. This has been an interesting week for cell and gene therapies, with two landmark FDA approvals, two significant fundraising efforts and potentially ground-breaking study results in glioblastoma. The top stories: ‘Dual-target’ CAR-T cell therapy shrinks brain tumours Targeting two brain tumour-associated proteins – rather than one – with CAR-T cell therapy has shown promise as a strategy for reducing solid tumour growth in

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Craving snacks after a meal? It might be food-seeking neurons, not an overactive appetite

Science Daily: Pharmacology News

A new study has shown that food-seeking cells exist in a part of a mouse's brain usually associated with panic -- but not with feeding. Activating a selective cluster of these cells kicked mice into 'hot pursuit' of live and non-prey food, and showed a craving for fatty foods intense enough that the mice endured foot shocks to get them, something full mice normally would not do.

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CDC, AMA Issue Calls to Get Vaccinated Against Measles

Drugs.com

TUESDAY, March 19, 2024 -- Two of America's leading health organizations are highlighting a global rise in measles cases as yet another reason for families to make sure they get the measles vaccine.The U.S. Centers for Disease Control and.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Why You Want To Use Looker Studio For Data Visualization on BigQuery

Perficient: Drug Development

If you have built or are building a Data Lake on the Google Cloud Platform (GCP) and BigQuery you already know that BigQuery is a fully managed enterprise data warehouse that helps you manage and analyze your data with built-in features like machine learning, geospatial analysis, and business intelligence. BigQuery’s serverless architecture lets you use SQL queries to answer your organization’s biggest questions with zero infrastructure management.

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FDA approval represents ‘transformational progress’ in hypertension

Drug Discovery World

The US Food and Drug Administration (FDA) has approved Tryvio (aprocitentan) for the treatment of hypertension in combination with other antihypertensive drugs, to lower blood pressure in adult patients who are not adequately controlled on other drugs. Tryvio (aprocitentan) is an endothelin receptor antagonist that inhibits the binding of endothelin (ET)-1 to ETA and ETB receptors.

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Your dog understands that some words 'stand for' objects

Science Daily: Pharmacology News

It's no surprise that your dog can learn to sit when you say 'sit' and come when called. But a new study has made the unexpected discovery that dogs generally also know that certain words 'stand for' certain objects. When dogs hear those words, brain activity recordings suggest they activate a matching mental representation in their minds.

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Can You Build Muscle in Old Age? Yes, and an Expert Has Tips

Drugs.com

FRIDAY, March 22, 2024 -- If you're in your 60s, 70s or even older, you might think your days of productively pumping iron are behind you.That's just not true, said Dr. Adil Ahmed, an assistant professor in the Joseph Barnhart Department of.

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All Aboard! Visualize Business Impact with the Enterprise Cloud Transit Map

Perficient: Drug Development

Cloud modernization is the primary driver of digital transformation and impactful business value. Cloud platforms have evolved from core technology to disruptive ecosystems of strategic advantage. Migration and modernization are vital to reach new markets, deliver innovative products, improve resiliency, reduce costs, and improve customer experiences.

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Vitamin A and its role in psychiatric and other disorders

Drug Target Review

Could you describe the potential link between vitamin A levels and altered neuronal connectivity in psychiatric disorders? Vitamin A (retinol and all trans-retinoic acid) is important for brain development because it triggers the differentiation of neural progenitor cells into mature neurons with a complex dendritic arborisation (tree) with many connections with other neurons that collectively form the neural network that organises behaviour.

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Breathe, don't vent: Turning down the heat is key to managing anger

Science Daily: Pharmacology News

Venting about a source of anger might feel good in the moment, but it's not effective at reducing the rage, new research suggests. Instead, techniques often used to address stress -- deep breathing, mindfulness, meditation, yoga or even counting to 10 -- have been shown to be more effective at decreasing anger and aggression.

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As Treatments Ease Anxiety, Heart Risks Also Decline

Drugs.com

THURSDAY, March 21, 2024 -- People with heart disease can stay healthier if they address their emotional problems as well as their physical ailments, a new study says.Treating anxiety and depression reduced ER visits and hospitalizations among.

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We’re All Outraged! Turning Passion into Results.

Perficient: Drug Development

If you were to pop open any social media platform or news app right now and scroll through a couple dozen posts, you’ll easily get the feeling that everything is #%&$ falling apart. Everyone is mad at something. We now use the term “doomscrolling.” In the past we had Yellow Journalism and we are there once again. As humans we tend to get addicted to outrage and drama.

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Streamlining Science: How does Lab Automation Drive Efficiency?

sptlabtech

In today’s scientific landscape, labs are under immense pressure to reduce costs, shorten timelines, and maximize output, often from limited resources. Lab automation has emerged as an incredibly valuable tool to address these challenges, empowering researchers to streamline processes and accelerate discoveries. By optimizing common laboratory tasks and processes, lab automation continues to demonstrate its value to the life science community.

Science 100
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If faces look like demons, you could have this extraordinary condition

Science Daily: Pharmacology News

Imagine if every time you saw a face, it appeared distorted. Well, for those who have a very rare condition known as prosopometamorphopsia (PMO), which causes facial features to appear distorted, that is reality. A new study reports on a unique case of a patient with PMO. The research is the first to provide accurate and photorealistic visualizations of the facial distortions experienced by an individual with PMO.

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U.S. Falls Out of Top 20 in 'World's Happiest Countries' List

Drugs.com

WEDNESDAY, March 20, 2024 -- For the first time, the United States has fallen out of the top 20 spots on the annual world's happiest nations list.Americans are now No. 23, far behind the top five countries -- Finland (No.

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[Podcast] What if Digital Could Outsmart Climate Change? An Interview With Kristine Swan, Bayer

Perficient: Drug Development

In our latest podcast episode, Jim talks with Kristine Swan , the VP of Digital Transformation and IT at Bayer Crop Science , for a conversation that’s as rich and fertile as the soil our future depends on. Kristine brings a personal touch to the digital revolution in agriculture, drawing on her roots on a Missouri farm. With her at the helm, Bayer is not just sowing seeds but also sowing data – data that empowers farmers across the globe to tackle pressing challenges like climate change and sus

Science 105
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Beyond sensors and alerts: diabetic foot prevention requires more than the odd sock

On Medicine

In a recent blog post , I introduced our study developing a smart-sensing sock to detect and prevent diabetic foot ulcers caused by rubbing, and the importance of understanding patient context when designing health devices. We have now spoken with a range of people with diabetic neuropathy, as well as their carers and podiatrists, and asked them if, when, and how, they would use a device like the smart-sensing sock we are designing.

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Robotic metamaterial: An endless domino effect

Science Daily: Pharmacology News

If it walks like a particle, and talks like a particle. it may still not be a particle. A topological soliton is a special type of wave or dislocation which behaves like a particle: it can move around but cannot spread out and disappear like you would expect from, say, a ripple on the surface of a pond. Researchers now demonstrate the atypical behavior of topological solitons in a robotic metamaterial, something which in the future may be used to control how robots move, sense their surroundings

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U.S. Abortion Rates Rose After Dobbs Decision, Led by Medication Abortions

Drugs.com

TUESDAY, March 19, 2024 -- Following the historic reversal of Roe v. Wade in June of 2022, the number of abortions in the United States has risen to more than a million per year, with medication abortions representing nearly two-thirds of those.

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Showing Grit When Performing Manual QA

Perficient: Drug Development

Many times, in my career when performing QA, I’ve dealt with many times where I’ve felt uncertain about my efforts. Through my work at Perficient—and with the help of my team—I’ve learned over time how to persist and show grit in testing to be able to ensure the highest quality of work delivered throughout a project. Here are some tips to help your breakthrough any blockers you may have when performing QA.

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The digital divide: Balancing automation and human interaction regardless of the patient support program model

BioPharma Drive: Drug Pricing

Balancing automated patient support with human touch is key in healthcare. Hybrid models offer a pragmatic path forward, prioritizing patient-centricity.

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Backyard insect inspires invisibility devices, next gen tech

Science Daily: Pharmacology News

Leafhoppers, a common backyard insect, secrete and coat themselves in tiny mysterious particles that could provide both the inspiration and the instructions for next-generation technology, according to a new study. In a first, the team precisely replicated the complex geometry of these particles, called brochosomes, and elucidated a better understanding of how they absorb both visible and ultraviolet light.

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Working-Age Americans Are Dying at Much Higher Rates Than Peers in Other Wealthy Nations

Drugs.com

FRIDAY, March 22, 2024 -- Working stiffs in the United States are dying at higher rates than those in other wealthy nations, a new study finds.Death rates among working-age Americans are 2.5 times higher than the average of other high-income.

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