Drugs.com
MARCH 12, 2025
WEDNESDAY, March 12, 2025 -- Only 17 percent of adults say they want to see Medicaid funding decreased, while 42 percent think funding should increase and 40 percent think it should be kept about the same, according to results of the February 2025.
Chemical Biology and Drug Design
MARCH 14, 2025
Fragment-based drug discovery (FBDD) was applied to cytochrome P450 3A4 reconstituted in Nanodiscs (NDs) with various lipid compositions. The choice of ND lipid influenced drug membrane interactions and fragment hit rates, demonstrating the critical role of the membrane environment in fragment screening for membrane proteins. ABSTRACT Membrane proteins (MPs) are important yet challenging targets for drug discovery.
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Covalent Modifiers
MARCH 8, 2025
Beatrice Noce, Sara Marchese, Marta Massari, Chiara Lambona, Joana Reis, Francesco Fiorentino, Alessia Raucci, Rossella Fioravanti, Mariana Castela, Alessandro Mormino, Stefano Garofalo, Cristina Limatola, Lorenzo Basile, Andrea Gottinger, Claudia Binda, Andrea Mattevi, Antonello Mai, and Sergio Valente Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02644 NADPH oxidases (NOXs) are enzymes dedicated to reactive oxygen species (ROS) production and are implicated in cancer, neuroin
Sygnature Discovery
MARCH 14, 2025
Sygnature Discovery offers high throughput screening along with additional hit identification tools including virtual screening, knowledge-based design, and fragment screening. Employing a comprehensive strategy for hit identification, we use the most effective methods to accurately pinpoint hit series that have the highest potential for evolving into compounds with drug-like properties.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
PPD
MARCH 11, 2025
While individual rare diseases affect populations that are small in numbers, collectively they impact millions globally, posing significant health and research challenges. While there is no universally accepted definition for rare disease, it is estimated that more than 10,000 distinct rare conditions exist, and people living with these rare diseases represent as much as 10% of the global population.
Chemical Biology and Drug Design
MARCH 13, 2025
Design and synthesis of pyrrole-tethered bisbenzoxazole (PTB) derivatives reveal potent anticancer activity against MCF-7 breast cancer cells. Compounds B8 , B14 , and B18 exhibit ~20-fold lower IC 50 values than tamoxifen, induce early-stage apoptosis, and arrest the cell cycle at the G1 phase via caspase-9 activation. These findings position PTB derivatives as promising candidates for targeted breast cancer therapy.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Perficient: Drug Development
MARCH 12, 2025
Intro In this post, we’ll take a look at a couple Sitecore SDKs commonly used to build XM Cloud head applications. Specifically, we’ll be looking at how to disable cookies used by these SDKs. This can be useful for data privacy and/or regulatory compliance reasons. These SDKs allow your application to integrate with other composable Sitecore services like analytics, personalization, and search.
Fierce BioTech
MARCH 14, 2025
Innovations in Analytical Testing, Biopharma, and Manufacturing Access our report today for a deep dive into the critical advancements shaping the future of pharmaceutical development. Discover how to ensure drugs meet the highest standards before they reach the market. smarcus Fri, 03/14/2025 - 09:39 Access our report today for a deep dive into the critical advancements shaping the future of pharmaceutical development.
Chemical Biology and Drug Design
MARCH 12, 2025
We have discovered a novel non-covalent MurA inhibitor as an antibacterial agent through machine learning and bioactivity testing. This is the first to use machine learning for virtual screening of non-covalent inhibitors of MurA. ABSTRACT The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis.
Broad Institute
MARCH 11, 2025
Count Me In launches new patient-partnered research project for translocation renal cell carcinoma By Corie Lok March 11, 2025 Breadcrumb Home Count Me In launches new patient-partnered research project for translocation renal cell carcinoma The effort will engage with patients, empowering them to share their unique health data with scientists to accelerate research.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Perficient: Drug Development
MARCH 11, 2025
Perficient’s talented colleagues from around the world bring unique perspectives that spark innovation and shatter boundaries. By fostering a culture that champions growth and celebrates every individual, were forging deep, meaningful connections that drive our success. Meet Joe Tufo, lead technical consultant, whose unwavering dedication to mentoring has promoted greater collaboration across Perficients Sitecore practice.
Science Daily: Pharmacology News
MARCH 12, 2025
Large, undisturbed forests are better for harboring biodiversity than fragmented landscapes, according to recent research. Ecologists agree that habitat loss and the fragmentation of forests reduces biodiversity in the remaining fragments. But ecologists don't agree whether it's better to focus on preserving many smaller, fragmented tracts of land or larger, continuous landscapes.
Drug Patent Watch
MARCH 13, 2025
Navigating the Complex World of Biosimilar Supply Chains As the demand for biosimilars continues to grow, so do the challenges associated with their supply chains. From manufacturing and quality control to distribution and regulatory compliance, the stakes are high for pharmaceutical companies looking to bring these life-changing treatments to market.
FDA Law Blog: Biosimilars
MARCH 12, 2025
The American Conference Institutes 21st Annual Paragraph IV Disputes is scheduled to take place from April 29-30, 2025 at The Altman Building in New York, NY. Widely recognized as the industry gold standard, the conference unites leaders from brand-name and generic drug companies, alongside federal judges, the U.S. PTOs PTAB, the FTC, and the FDA, to tackle the critical legal, regulatory, and business issues shaping pharmaceutical patent litigation.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Perficient: Drug Development
MARCH 11, 2025
In the ever-evolving landscape of cloud computing, Infrastructure as Code (IaC) has emerged as a cornerstone practice for managing and provisioning infrastructure. IaC enables developers to define infrastructure configurations using code, ensuring consistency, automation, and scalability. AWS CloudFormation, a key service in the AWS ecosystem, simplifies IaC by allowing users to easily model and set up AWS resources.
Science Daily: Pharmacology News
MARCH 13, 2025
A recent study has reclassified the species commonly known as the Javan rhinoceros, proposing a more precise scientific name: Eurhinoceros sondaicus. The research highlights key differences in body structure and ecology that set this species apart from the Indian rhinoceros (Rhinoceros unicornis). Recognizing it as a separate genus not only improves scientific understanding but also has important implications for conservation efforts.
Drug Patent Watch
MARCH 10, 2025
The Future of Generic Drugs: How Technology is Revolutionizing the Industry As we continue to navigate the ever-changing landscape of healthcare, one thing is clear: technology is playing an increasingly important role in shaping the future of generic drug development. From AI-powered discovery to 3D printing, the latest advancements are not only speeding up the process but also making it more efficient and cost-effective.
BioPharma Drive: Drug Pricing
MARCH 13, 2025
The joint venture with generative AI firm Hologen hands MeiraGTx $200 million up front as well as other financial perks — a “transformative” deal, according to the company’s CEO.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Perficient: Drug Development
MARCH 13, 2025
Perficient has a FinOps mindset with Databricks , so the Automatic Liquid Clustering announcement grabbed my attention. I’ve mentioned Liquid Clustering before when discussing the advantages of Unity Catalog beyond governance use cases. Unity Catalog : come for the data governance , stay for the predictive optimization. I am usually a fan of being able to tune the dials of Databricks.
Science Daily: Pharmacology News
MARCH 12, 2025
Researchers have announced the creation of the first operating system designed for quantum networks: QNodeOS. The research marks a major step forward in transforming quantum networking from a theoretical concept to a practical technology that could revolutionize the future of the internet.
Drug Patent Watch
MARCH 10, 2025
The Secret to Protecting Your Pharmaceutical Innovations: A Proven Patent Strategy As a pharmaceutical professional, you know how crucial it is to safeguard your groundbreaking discoveries. But with the ever-changing landscape of patent law, it's easy to get left behind. That's why we've put together a comprehensive guide to help you navigate the complex world of pharmaceutical patents.
Drugs.com
MARCH 14, 2025
FRIDAY, March 14, 2025 -- Senate Democrats are raising concerns about Dr. Mehmet Ozs nomination to lead the Centers for Medicare and Medicaid Services (CMS), alleging he significantly underpaid Medicare and Social Security taxes in recent years.A m.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Perficient: Drug Development
MARCH 12, 2025
SFTP? Isn’t that old? It is an oldie, but a goodie. With Data Cloud we can send data to a lot of external data sources like Marketing Cloud Engagement or Amazon S3 through Activation Targets. But there are times we are working with a destination system like Eloqua or Marketo that has solid support for SFTP. SFTP and Data Cloud work well together!
Science Daily: Pharmacology News
MARCH 13, 2025
The 2025 U. S. State of the Birds Report, produced by a coalition of leading science and conservation organizations, reveals continued widespread declines in American bird populations across all mainland and marine habitats, with 229 species requiring urgent conservation action.
Drug Patent Watch
MARCH 12, 2025
The Unseen Heroes of Generic Drugs: Stability Testing 101 As a consumer, have you ever stopped to think about the rigorous process that goes into bringing a generic version of your favorite medication to market? It's not just a matter of copying a formula and slapping a new label on it. Behind the scenes, generic drug manufacturers are working tirelessly to ensure that their products are safe, effective, and identical to their branded counterparts.
BioPharma Drive: Drug Pricing
MARCH 10, 2025
A study in people with obesity and diabetes again found CagriSema helps people lose weight, but not by enough to clearly surpass Eli Lilly’s Zepbound.
Perficient: Drug Development
MARCH 14, 2025
Shoptalk Spring 2025 in Las Vegas is only a few weeks away, and our experts cannot wait to reconnect with brands and discuss where the industry is headed. They have been busy scheduling meetings , packing their mics, and making predictions about which technologies and strategies retailers and ecommerce brands will be placing their bets on this year.What do they believe is a safe bet?
Science Daily: Pharmacology News
MARCH 11, 2025
Researchers were shocked to see that bacteria's antimicrobial resistance is strengthened when exposed to plastic particles and point to a potential outsized impact on refugees.
Drugs.com
MARCH 14, 2025
FRIDAY, March 14, 2025 -- Only 43 percent of parents report they are able to find accurate and current information on avian influenza A(H5N1), commonly known as bird flu, according to the University of Michigan Health C.S. Mott Children's Hospital.
BioPharma Drive: Drug Pricing
MARCH 11, 2025
The deal ends 2Seventy’s short run as an independent company, during which it restructured, sold off research and lost nearly all of its market value.
Perficient: Drug Development
MARCH 10, 2025
Are you using Vercel to supercharge your Sitecore experience? If so, youre already benefiting from a powerful, globally optimized platform designed for modern web applications. But did you know you can take your performance even further? Vercel Fluid Compute is a game-changer, optimizing workloads for higher efficiency, lower costs, and enhanced scalability perfect for high-performance Sitecore deployments.
Science Daily: Pharmacology News
MARCH 10, 2025
New research has revealed that people often do not perceive the true meaning of their pet's emotions and can misread their dog. The reasons for this are many and include a human misunderstanding of dog expressions due to a bias towards projecting human emotions onto our pets.
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