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Targeting a human protein may stop Ebola virus in its tracks

The Pharma Data

The researchers found that Ebola virus polymerase leverages host protein GSPT1 to positively regulate viral transcription – a process the virus uses to convert its genetic material into instructions for making viral proteins. “We weren’t expecting to see this,” says Fang.

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Article FDA Thank You Draft guidance on potency assays for CGT products garners extensive stakeholder input

Agency IQ

BY RACHEL COE, MSC | APR 11, 2024 1:06 PM CDT Regulatory background: Product potency and assays As defined in statute , the FDA uses the term “potency” to refer to the “specific ability or capability” of a product to “effect a given result.” morphological cell changes or alterations in protein production or expression).

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Codon Digest: Bacteria Resist Every Virus

Codon

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Evolutionary-scale prediction of atomic-level protein structure with a language model. Biological Engineering Generation of functional oocytes from male mice in vitro. Metabolic Engineering. Metabolic Engineering.

Virus 52
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Beyond Steel Tanks

Codon

In the first real test of delivering a complex biomolecule to over a billion people, little has changed from how Genentech first approached manufacturing in the 1980s; Cells are genetically engineered and then grown in steel tanks. In response to this hysteria, regulation was aggressively tightened. Why rock the boat?

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The Codon Guide to Synthetic Biology

Codon

Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. ” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Gene Expression and Regulation. Link Regulating synthetic gene networks in 3D materials , by Deans T.L.

DNA 98
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The Codon Guide to Synthetic Biology

Codon

Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. ” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Gene Expression and Regulation. Journal of Biological Engineering (2010). Nature (2005). & Xie X.S.

DNA 52
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Toxic Proteins for Drug Discovery

Codon

This class of drugs was engineered to mimic the body’s glucagon-like peptide-1 hormone (GLP-1), which decreases blood glucose levels by activating its receptor to signal the release of insulin. This is the step after the initial transcription of DNA into mRNA by RNA Polymerase II, the protein to which alpha amanitin binds.

Drugs 107