Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. Nature reviews immunology [Internet] 2008 July [2023 November 10]; 8:523-32. It is challenging to change a cell’s identity, even from an infection-fighting T cell to a regulatory T cell.

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Government DNA RNA Regulations 104

Drug Target Review

FEBRUARY 7, 2024

For example, innate immune peptides being imitated by SARS-CoV-2 fragments have a special ability to organise double stranded RNA into structures that strongly amplify activation of the human innate immune system in autoimmune diseases. He currently serves on the Editorial Board of Physical Review E.

RNA 69

RNA Virus Immune Response Engineering 69

Metabolite Tales Blog

JANUARY 26, 2023

Table 1 – Small molecule drugs approved by the FDA in 2022 and the major reported route of biotransformation *Note: 17 small molecule drugs as classified in C&EN ( [link] i.e. excluding antibody-drug conjugates, antibodies, proteins, radioligands and small interfering RNA). References Iversen et al., Basic Clin Pharmacol Toxicol.

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Small Molecule FDA Approval FDA Drugs 52

Codon

JUNE 11, 2024

Their solution was to fuse hairpins, little loops made from RNA or DNA, at various positions along the DNA strand that was being sequenced. But in 2008 , physicists at the University of Washington made a nanopore sequencer using a protein, called MspA, from Mycobacterium smegmatis, a bacterium first described in the 1880s.

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DNA Engineering RNA Small Molecule 96

Codon

FEBRUARY 20, 2024

At any given moment, thousands of messenger RNAs are being translated into proteins by ribosomes, which are protein-making machines that are, themselves, made from a mixture of proteins and RNA. In 2008, researchers at UC Berkeley devised an ingenious solution. But again, how do we know? This paper is one example.

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RNA DNA Engineering Cell Biology 98

Drug Target Review

MARCH 21, 2024

Additionally, the COVID-19 RNA vaccines have already demonstrated how safe RNA can be, and we look forward to seeing additional safety data on RNA approaches as the field continues to grow. 2008 Sep 1;17(17):2622-32. AAV-based therapies often can’t be dosed more than once due to concerns about an immune response.

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Therapies RNA Immune Response Treatment 64

BMG Labtech

DECEMBER 20, 2024

Absorbance measurements at this specific wavelength can be used to determine DNA or RNA concentrations quickly. Online corrected version: (2008) "Absorbance". Another crucial parameter is DNA purity since impurities or contaminants may affect the successful implementation of subsequent experiments using purified DNA samples.

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DNA Science Laboratories RNA 52