Drug Target Review

JUNE 5, 2025

Currently, three FDA-approved disease-modifying drug therapies are available: hydroxyurea, crizanlizumab and L-glutamine, though each has limitations that affect patient compliance. The use of FDA-approved medications for preventing vaso-occlusive events in sickle cell disease. Published March 2016. JAMA Netw Open.

Disease 52

Disease Treatment Therapies Nurses 52

Drug Target Review

AUGUST 29, 2024

MR : Chimeric antigen receptor T-cell (CAR-T) therapy is very effective in treating patients with B-cell lymphoma, leukemia, and multiple myeloma, where we have six FDA-approved drugs. What potential advantages does the CD5 modulation strategy offer over traditional CAR-T therapies?

Therapies 59

Therapies Treatment Engineering Molecular Biology 59

Codon

JUNE 5, 2025

The treatment, now known as Casgevy, became the first CRISPR-based therapy to gain FDA approval, in 2023. Therapeutics There are no FDA-approved therapies built upon Cas12, but the enzyme is currently being used in multiple clinical trials. It was first characterized in 2016 by Feng Zhang’s lab.

DNA 78

DNA RNA Clinical Trials Engineering 78

Broad Institute

APRIL 25, 2024

Christian Happi Christian Happi However, in other parts of West Africa , Ebola was spreading, infecting nearly 29,000 people and killing more than 11,000 before the outbreak was contained in 2016. This year they began testing for 19 bloodborne pathogens such as Ebola, yellow fever, Lassa, and HIV.

Virus 132

Virus Hospitals Disease Government 132

Codon

JUNE 18, 2024

Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. By 2016, Shapiro had set up a research laboratory at the California Institute of Technology in Pasadena and began to devote his attention entirely to gas vesicles.

Engineering 70

Engineering Laboratories International Clinical Trials 70