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Gene editing extends lifespan in mouse model of prion disease

Broad Institute

In 2018, Liu, who works on the same floor as Minikel and Vallabh at Broad, approached them and proposed a collaboration. His lab had just developed base editing, a gene-editing approach that makes single-letter changes in DNA and can shut down protein production using strategies including installing a stop signal in the genetic code.

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Key considerations before commencing cell line development

Drug Target Review

5 And for the latter, the development of a technique to temporally track gene expression in CHO cells, which therefore has the potential to lead to the identification of targets to improve recombinant protein production. 2018) 34(6): 1460-1471. PDA J Pharm Sci Technol (2018), 72(4): 438-450. Wang B, Albanetti T, et al.

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Targeting a human protein may stop Ebola virus in its tracks

The Pharma Data

Back in 2018, researchers tested a broad-spectrum antiviral candidate called remdesivir/VEKLURY, which acts as a nucleotide decoy to get incorporated into the viral RNA genome and stop viral polymerase. . “The virus hijacks this protein and makes it do something different than its normal job in cells.

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JS Bio and Etta Biotech Advancing Strategic Partnership

The Pharma Data

Etta Biotech”), to set up a high titer transient protein expression platform for high quality protein production using JS Bio’s transient transfection media. JS Bio becomes the exclusive cell culture supplier for Etta Biotech’s transient transfection high titer protein expression platform.

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Merkin Prize in Biomedical Technology awarded to F. William Studier for development of widely used protein- and RNA-production platform

Broad Institute

When proteins are the desired end result, the E. coli molecular machinery for translating mRNA into proteins is used after the T7 system makes the RNA. Studier continued studying the T7 polymerase and promoter, fine-tuning the system for years, and publishing new improved versions as recently as 2018.

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The Codon Guide to Synthetic Biology

Codon

Artificial Life (2018). Nature Biotechnology (2018). Science (2018). Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. eLife (2018). Link Modelling and analysis of gene regulatory networks , by Karlebach G. & & Shamir R. Science (2017).

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The Codon Guide to Synthetic Biology

Codon

Artificial Life (2018). Nature Biotechnology (2018). Science (2018). Link The PURE system for the cell-free synthesis of membrane proteins , by Kuruma Y. & Link An integrated cell-free metabolic platform for protein production and synthetic biology , by Jewett M.C. & Shamir R. Science (2017).

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