Bioethics and Disease - Drug Discovery Digest

MPG Primer: Setting up a Biobank: Who? What? Why?

Broad Institute

FEBRUARY 13, 2025

The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

Nixing the Newborn Screening Advisory Committee Is Ill-Advised

PLOS: DNA Science

APRIL 17, 2025

Next month, families affected by the rare genetic disease metachromatic leukodystrophy (MLD) will meet in Washington. Because Calliope Joy didn’t have an older sibling with the disease, her initial symptoms were confusing. For example, only a dozen states screen for Krabbe Disease , which is similar to MLD.

Therapies

Therapies Bioethics DNA Organic Chemistry

Advancing and Safeguarding Clinical Research for a Better Tomorrow

Advarra

MARCH 6, 2025

Innovations in fields such as immunotherapy, cancer and chronic diseases owe their existence to clinical trials, which judiciously test and evaluate safety and efficacy. Without clinical research, these medical breakthroughs would remain out of reach for patients.

Clinical Research

Clinical Research Research Clinical Trials Bioethics

Something in the Air – Environmental DNA Update

PLOS: DNA Science

JUNE 26, 2025

Team leader David Duffy, professor of wildlife disease genomics at the University of Florida‘s Whitney Laboratory for Marine Bioscience, was surprised at the ease of sampling and analyzing the eDNA. The approach can detect emerging infectious diseases like new flu or COVID variants, as well as track allergens.

DNA

DNA Bioethics Science Laboratories

Leveraging large biobanks to study genetics of human traits and diseases

Broad Institute

APRIL 10, 2025

Leveraging large biobanks to study genetics of human traits and diseases By Rose Circeo April 10, 2025 Breadcrumb Home Leveraging large biobanks to study genetics of human traits and diseases The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Disease

Disease Bioethics Research

A Practical Primer on Bayesian Statistics

Broad Institute

APRIL 17, 2025

A Practical Primer on Bayesian Statistics By Rose Circeo April 17, 2025 Breadcrumb Home A Practical Primer on Bayesian Statistics The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

MPG Primer: Fine-mapping Complex Traits in Biobanks

Broad Institute

APRIL 3, 2025

MPG Primer: Fine-mapping Complex Traits in Biobanks By Rose Circeo April 3, 2025 Breadcrumb Home MPG Primer: Fine-mapping Complex Traits in Biobanks The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Polygenic risk scores: method development and application

Broad Institute

JANUARY 23, 2025

Polygenic risk scores: method development and application By Rose Circeo January 23, 2025 Breadcrumb Home Polygenic risk scores: method development and application The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Single-cell Multiome Technology and Analysis Methods

Broad Institute

JANUARY 16, 2025

Single-cell Multiome Technology and Analysis Methods By Rose Circeo January 16, 2025 Breadcrumb Home Single-cell Multiome Technology and Analysis Methods The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Linear Models for GWAS Analysis

Broad Institute

JANUARY 9, 2025

Linear Models for GWAS Analysis By Rose Circeo January 9, 2025 Breadcrumb Home Linear Models for GWAS Analysis The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

A Comparative Genomics Strategy To Discover Mechanisms of Cellular Resilience

Broad Institute

OCTOBER 31, 2024

A Comparative Genomics Strategy To Discover Mechanisms of Cellular Resilience By Rose Circeo October 31, 2024 Breadcrumb Home A Comparative Genomics Strategy To Discover Mechanisms of Cellular Resilience The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Genome-Wide Association Studies (GWAS): A Refreshed Perspective

Broad Institute

OCTOBER 3, 2024

Genome-Wide Association Studies (GWAS): A Refreshed Perspective By Rose Circeo October 3, 2024 Breadcrumb Home Genome-Wide Association Studies (GWAS): A Refreshed Perspective The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

MPG Primer: Connecting GWAS and eQTLs through colocalization

Broad Institute

OCTOBER 10, 2024

MPG Primer: Connecting GWAS and eQTLs through colocalization By Rose Circeo October 10, 2024 Breadcrumb Home MPG Primer: Connecting GWAS and eQTLs through colocalization The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Introduction to population genetics

Broad Institute

SEPTEMBER 19, 2024

Introduction to population genetics By Rose Circeo September 19, 2024 Breadcrumb Home Introduction to population genetics The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

Cellarium

Broad Institute

JUNE 6, 2024

Cellarium By Rose Circeo June 6, 2024 Breadcrumb Home Cellarium The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

Sequencing and analysis of long-read whole genome data

Broad Institute

JUNE 13, 2024

Sequencing and analysis of long-read whole genome data By Rose Circeo June 13, 2024 Breadcrumb Home Sequencing and analysis of long-read whole genome data The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Introduction to Pharmacogenetics

Broad Institute

MAY 30, 2024

Introduction to Pharmacogenetics By Rose Circeo May 30, 2024 Breadcrumb Home Introduction to Pharmacogenetics The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Pharmacogenetics

Pharmacogenetics Bioethics Disease Research

Structural Variation in Human Genomes

Broad Institute

APRIL 25, 2024

Structural Variation in Human Genomes By Rose Circeo April 25, 2024 Breadcrumb Home Structural Variation in Human Genomes The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

Genomic Interpretation, seqr and Matchmaker Exchange

Broad Institute

MAY 9, 2024

Genomic Interpretation, seqr and Matchmaker Exchange By Rose Circeo May 9, 2024 Breadcrumb Home Genomic Interpretation, seqr and Matchmaker Exchange The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Understand Single Cell ATAC-Seq Data Analysis

Broad Institute

APRIL 11, 2024

Understand Single Cell ATAC-Seq Data Analysis By Rose Circeo April 11, 2024 Breadcrumb Home Understand Single Cell ATAC-Seq Data Analysis The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Rare Variant Interpretation

Broad Institute

MARCH 22, 2024

Rare Variant Interpretation By Rose Circeo March 22, 2024 Breadcrumb Home Rare Variant Interpretation The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

Ethical considerations in genomics research

Broad Institute

FEBRUARY 15, 2024

Ethical considerations in genomics research By Rose Circeo February 15, 2024 Breadcrumb Home Ethical considerations in genomics research The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Research

Research Bioethics Disease

Integration of GWAS and functional data

Broad Institute

FEBRUARY 8, 2024

Integration of GWAS and functional data By Rose Circeo February 8, 2024 Breadcrumb Home Integration of GWAS and functional data The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

A brief history of non-invasive prenatal testing

Broad Institute

FEBRUARY 1, 2024

A brief history of non-invasive prenatal testing By Rose Circeo February 1, 2024 Breadcrumb Home A brief history of non-invasive prenatal testing The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

MPG Primer: All of Us Primer, Part 2

Broad Institute

JANUARY 18, 2024

MPG Primer: All of Us Primer, Part 2 By Rose Circeo January 18, 2024 Breadcrumb Home MPG Primer: All of Us Primer, Part 2 The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

MPG Primer: All of Us Primer, Part 1

Broad Institute

JANUARY 11, 2024

MPG Primer: All of Us Primer, Part 1 By Rose Circeo January 11, 2024 Breadcrumb Home MPG Primer: All of Us Primer, Part 1 The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

MPG Primer: Basics of gene editing/CRISPR

Broad Institute

DECEMBER 7, 2023

MPG Primer: Basics of gene editing/CRISPR By Rose Circeo December 7, 2023 Breadcrumb Home MPG Primer: Basics of gene editing/CRISPR The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

MPG Primer: Introduction to fine-mapping

Broad Institute

OCTOBER 19, 2023

MPG Primer: Introduction to fine-mapping By Rose Circeo October 19, 2023 Breadcrumb Home MPG Primer: Introduction to fine-mapping The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

MPG Primer: Modeling rare variation and calculating genetic constraint

Broad Institute

OCTOBER 12, 2023

MPG Primer: Modeling rare variation and calculating genetic constraint By Rose Circeo October 12, 2023 Breadcrumb Home MPG Primer: Modeling rare variation and calculating genetic constraint The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Mono- and bi-valent allele impact

Broad Institute

SEPTEMBER 28, 2023

Mono- and bi-valent allele impact By Rose Circeo September 28, 2023 Breadcrumb Home Mono- and bi-valent allele impact The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

Harmonization of deeply sequenced genomes

Broad Institute

JUNE 21, 2023

Harmonization of deeply sequenced genomes By admin June 21, 2023 Breadcrumb Home Harmonization of deeply sequenced genomes The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis

Broad Institute

APRIL 4, 2024

A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis By Rose Circeo April 4, 2024 Breadcrumb Home A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

RNA

RNA Bioethics Disease Research

MPG Primer: Broad Clinical Labs: Sequencing Technology Landscape and Current Offerings Overview

Broad Institute

NOVEMBER 30, 2023

Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing

Broad Institute

JUNE 1, 2023

Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing By Rose Circeo June 1, 2023 Breadcrumb Home Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

Bioethics

Bioethics Disease Research

Navigating the neuroscientific landscape with Dr Judy Illes

Drug Target Review

DECEMBER 19, 2023

On the neurologic side, there are findings about neurotoxins and environmental contaminants showing correlations with a variety of neurologic diseases across the lifespan from children to adults. On the mental health side, there is anxiety around climate change – Eco-Anxiety.

Science

Science Bioethics International Research

BetterLife’s Recent Acquisition: Taking LSD from Experimental to a Major Therapeutic Application

The Pharma Data

DECEMBER 14, 2020

Authors of “ An ethical exploration of barriers to research on controlled drugs ” in the American Journal of Bioethics have been quoted stating, “the classification of drugs as Schedule I amounts to an unsurmountable barrier to research.” For further information please visit www.abetterlifephama.com.

Bioethics

Bioethics Clinical Research Regulations Clinical Trials

How Targeted Cancer Drugs Disrupt the Cell Cycle

PLOS: DNA Science

JUNE 22, 2023

Cancer cells make too much survivin, with levels increasing as the disease spreads and becomes more aggressive. It delayed disease progression and more than doubled survival time, adding 17 months. I had the privilege to meet one of the first people to receive Gleevec, which I wrote about for Bioethics Today in 2006.

Drugs

Drugs Small Molecule DNA Bioethics

Deliberate Dysentery

Codon

JANUARY 21, 2024

Today, refined versions of these human challenge studies have become standard practice in testing vaccines for vector-borne diseases (e.g., yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying pathogenesis, the process by which a disease develops. How are disease targets selected for challenge trials?

Vaccine

Vaccine Trials Disease Treatment

The Codon Guide to Synthetic Biology

Codon

AUGUST 10, 2023

Drug Discovery Today: Disease Models (2008). Link Artificial Gene Regulatory Networks—A Review , by Cussat-Blanc S. Artificial Life (2018). Link Mathematical modeling and synthetic biology , by Chandran D. Link 📙 Courses * = Recommended What is Synthetic Biology?

DNA

DNA Cell Biology Molecular Biology Engineering

The Codon Guide to Synthetic Biology

Codon

AUGUST 10, 2023

Drug Discovery Today: Disease Models (2008). Link Artificial Gene Regulatory Networks—A Review , by Cussat-Blanc S. Artificial Life (2018). Link Mathematical modeling and synthetic biology , by Chandran D. Link 📙 Courses * = Recommended What is Synthetic Biology?

DNA

DNA Cell Biology Engineering Molecular Biology

Introduction to scRNAseq workflow

Broad Institute

FEBRUARY 6, 2025

Introduction to scRNAseq workflow By Rose Circeo February 6, 2025 Breadcrumb Home Introduction to scRNAseq workflow The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Several talks each year focus on bioethical considerations in genomics research.

Bioethics

Bioethics Disease Research

Equity + Ethical, Legal, Social Implications in Biomedicine Seminar Series

Broad Institute

APRIL 9, 2025

This panel will highlight the urgent need for greater investment in a broader range of health conditions that disproportionately impact, uniquely affect, or present differently in women, including pregnancy, polycystic ovary syndrome, endometriosis, menopause, and cardiovascular disease.

Bioethics

Bioethics Science Clinical Research Hospitals

MPG Primer: Setting up a Biobank: Who? What? Why?

Nixing the Newborn Screening Advisory Committee Is Ill-Advised

Trending Sources

Advancing and Safeguarding Clinical Research for a Better Tomorrow

Something in the Air – Environmental DNA Update

Leveraging large biobanks to study genetics of human traits and diseases

A Practical Primer on Bayesian Statistics

MPG Primer: Fine-mapping Complex Traits in Biobanks

Polygenic risk scores: method development and application

Single-cell Multiome Technology and Analysis Methods

Linear Models for GWAS Analysis

A Comparative Genomics Strategy To Discover Mechanisms of Cellular Resilience

Genome-Wide Association Studies (GWAS): A Refreshed Perspective

MPG Primer: Connecting GWAS and eQTLs through colocalization

Introduction to population genetics

Cellarium

Sequencing and analysis of long-read whole genome data

Introduction to Pharmacogenetics

Structural Variation in Human Genomes

Genomic Interpretation, seqr and Matchmaker Exchange

Understand Single Cell ATAC-Seq Data Analysis

Rare Variant Interpretation

Ethical considerations in genomics research

Integration of GWAS and functional data

A brief history of non-invasive prenatal testing

MPG Primer: All of Us Primer, Part 2

MPG Primer: All of Us Primer, Part 1

MPG Primer: Basics of gene editing/CRISPR

MPG Primer: Introduction to fine-mapping

MPG Primer: Modeling rare variation and calculating genetic constraint

Mono- and bi-valent allele impact

Harmonization of deeply sequenced genomes

A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis

MPG Primer: Broad Clinical Labs: Sequencing Technology Landscape and Current Offerings Overview

Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing

Navigating the neuroscientific landscape with Dr Judy Illes

BetterLife’s Recent Acquisition: Taking LSD from Experimental to a Major Therapeutic Application

How Targeted Cancer Drugs Disrupt the Cell Cycle

Deliberate Dysentery

The Codon Guide to Synthetic Biology

The Codon Guide to Synthetic Biology

Introduction to scRNAseq workflow

Equity + Ethical, Legal, Social Implications in Biomedicine Seminar Series

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