Dark Matter Blog

APRIL 4, 2023

The tools in this kit fall into a few broad categories: understanding protein structures and their functional significance, identifying ligands that bind into functionally significant pockets, and developing assays that confirm target engagement along with demonstrating the anticipated impact on cell biology.

Small Molecule

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production

PerkinElmer

JANUARY 21, 2022

Accelerating Capabilities for Dementia Biomarker Discovery To achieve that goal, the Dementia Platform’s focus involves studying the disease from many points of view – from lifestyle, age, and cognitive function, to genetics, cell biology, and phenotypic screening. Mrc.ukri.org. 2022 [cited 6 January 2022].

Cell Biology

Codon

FEBRUARY 20, 2024

As scientists devise more experiments and take more measurements, they often make them available in papers, pre-prints, websites and blogs. Credit: Rob Phillips and Ron Milo, Cell Biology by the Numbers. 3 Part of the beauty of science is that it builds upon itself, one experiment at a time. These numbers suggest that E.

RNA

Codon

FEBRUARY 28, 2023

I felt like a scientist for the first time, and I began to grasp the “numbers of biology” (many calculations in this essay come from that course and another textbook, Cell Biology by the Numbers.) Without mathematics, I learned, biology is naked; we can only comprehend it at arm's length.

RNA

Codon

OCTOBER 22, 2024

As another example of how peer review can be augmented, The Journal of Cell Biology has successfully implemented an “ image integrity check ” to help cut down on improper image manipulation. The implementation of CLAIM has benefited the journal’s readership and is pushing the field in a much-needed direction.

Science

BMG Labtech

MARCH 8, 2023

Further, the following blog post discusses ROS detection in general. Cellular redox changes can be monitored in different ways. One approach is to use genetically encoded biosensors based on redox-sensitive GFP (roGFP). References [link] [link] Bouché C, The cellular fate of glucose and its relevance in type 2 diabetes, Endocrine Reviews.

Molecular Biology

Codon

APRIL 2, 2023

An open-source FACS automation system for high-throughput cell biology. Read Thanks for skimming, — Niko McCarty Email | Twitter | LinkedIn Disclosure: The views expressed in this blog are entirely my own and do not represent the views of any company or university with which I am affiliated. Might be useful! Wiener D.M.

DNA

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Caption: Cyclic peptide (middle) binds to iPGM (blue). Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind are probably viruses and bacteria. But parasites are another important source of devastating infection, especially in the developing world.

Small Molecule

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. That’s a win.

Vaccine

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. That’s a win.

Vaccine

Codon

APRIL 9, 2023

Nature Cell Biology. 🔻 Thanks for skimming, — Niko McCarty Email | Twitter | LinkedIn Disclosure: The views expressed in this blog are entirely my own and do not represent the views of any company or university with which I am affiliated. Trends in Biotechnology. Read Julia for biologists. Nature Methods.

Therapies

Codon

SEPTEMBER 22, 2024

They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days. He also writes the blog De Novo.

DNA

Codon

APRIL 16, 2023

Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Biotechnology. Read Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.

Engineering

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA

BMG Labtech

FEBRUARY 24, 2025

In this blog, we look at some of the ways a microplate reader can be used to advance protein nitration and related research in the laboratory. Protein nitration assays are widely used in many research areas including but not limited to biochemistry , biotechnology , cell biology , microbiology , and molecular biology.

Small Molecule