New Drug Approvals

AUGUST 22, 2023

1951476-79-1 Hepatitis B virus (HBV) is an infectious disease that targets the liver resulting in either an acute infection, with symptoms arising in 45 to 160 days, or a chronic infection, which 350 million people worldwide are affected by. EIDD-2173; also known as ATI-2173 Fosclevudine alafenamide Phase 2 Molecular Weight 529.45

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. 📎 Papers Strands of DNA can be used to build molecular logic gates. If you want to edit a gene inside of a neuron, what do you do? From Stahl E.C.

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. 📎 Papers Strands of DNA can be used to build molecular logic gates. If you want to edit a gene inside of a neuron, what do you do? From Stahl E.C.

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Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. Read Switchable hydrophobic pockets in DNA protocells enhance chemical conversion. Nature Microbiology. Meeussen J.V.W.

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PerkinElmer

JULY 13, 2020

From this data, scientists have begun to try to classify different subtypes and create phylogenetic trees of the virus to understand how the viral genome is evolving as it spreads across the globe. The question as to whether these genome variations lead to different strains of the novel virus (i.e. Why and how do viruses evolve?

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Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. A phage is a virus that infects bacteria. Let’s be real.

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DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. A phage is a virus that infects bacteria. Let’s be real.

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Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

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Codon

APRIL 30, 2023

Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. The vaccine printer can make lots of different types of vaccines, including protein, DNA, and mRNA ones, but I’m sure this is all quite expensive right now. From Zhang et al.

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Advarra

JUNE 13, 2024

Recombinant DNA technologies and genetically modified biological agents are being adapted for a wide scope of therapeutic applications, and their use is becoming increasingly common in clinical trials. This blog describes why hazard communications are necessary and what an effective SOP should include.

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Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. Collections of mRNA have been understood as a proxy for cell states for decades.

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PerkinElmer

AUGUST 18, 2020

The time sensitivity of virus research, combined with an increasing complexity of bench tasks, can make it helpful for labs to increase automaticity of experiments. For this reason, it might be necessary for research teams to screen many potential leads before they find one or two with strong potential. Sources Zhang et al.

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Codon

APRIL 9, 2023

Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Read DNA Sequencing & Synthesis *Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing. Bergs A.C.F. Nature Communications. Porta-de-la-Riva M. Nature Methods.

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PerkinElmer

MAY 7, 2021

One important step of viral, and subsequently vaccine, research is the quantification of viral DNA libraries using plate readers. The post Hey…Walkaway on the Automated Side first appeared on PerkinElmer Blog. Once a viral genome is detected, isolated, multiplied, and purified, it must be quantified and then sequenced.

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PLOS: DNA Science

SEPTEMBER 7, 2023

As genetics morphed into genomics, artificial intelligence stepped in, layering the combinatorial information of comparative genomics onto DNA sequences. Train an algorithm on the DNA sequences of a known disease-causing gene, then search for identical or highly similar sequences in cells from other individuals to assist diagnosis.

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Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito.

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Codon

MAY 15, 2023

3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. Read more in Cell. ( #1 , #2 ) (Video credit: Gong Y.

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Codon

MAY 15, 2023

3/ Prime Editing Spree Prime editors can change DNA in ways that Cas9 — and even base editors — cannot. Known as a "search-and-replace" gene-editing tool, prime editors can delete or replace DNA up to 10,000 bases in length, or substitute one base for another. Read more in Cell. ( #1 , #2 ) (Video credit: Gong Y.

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Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

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Codon

MAY 22, 2023

And experiments at Tune Therapeutics showed that CRISPR epigenome editing — which doesn’t cut DNA at all, but merely silences genes by adding chemical groups to them — can curb “bad cholesterol” by more than 50% in monkeys. These tools do not cut or nick DNA, and so they may be safer than other options.

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Codon

MAY 18, 2023

shelves, it’s easy to find DNA in the air , and some weird insect cybernetics. 2/ Your DNA is Everywhere. A study published Monday in Nature Ecology & Evolution shows that tiny amounts of human DNA, shed into the soil or air, can be easily detected using little more than a $1,000 Nanopore MinION. Read more in WIRED.

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Codon

MAY 18, 2023

shelves, it’s easy to find DNA in the air , and some weird insect cybernetics. 2/ Your DNA is Everywhere. A study published Monday in Nature Ecology & Evolution shows that tiny amounts of human DNA, shed into the soil or air, can be easily detected using little more than a $1,000 Nanopore MinION. Read more in WIRED.

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addgene Blog

DECEMBER 3, 2024

Many different substances can be injected, including cells, drugs, DNA, viral vectors, and viruses. While not an exhaustive list, these can include what’s being injected, the type of experiment, the number of mice, the potential pain or discomfort of the mice, and restraint method.

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Codon

APRIL 16, 2023

Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. Perhaps there is now a way to use DNA to extract metals: You could fuse the DNA strands to an antibody, coat them onto electronics, and then use a column to isolate the DNA:metal compounds? coli DNA using a Retro-Cascorder.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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Codon

FEBRUARY 19, 2025

The same model can also generate brand-new DNA sequences at the scale of yeast chromosomes or small bacterial genomes. AI Architectures Before explaining how Evo 2 could make bioengineering more predictable, it helps to first understand how AI models actually “learn” the language of DNA.

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PLOS: DNA Science

OCTOBER 24, 2024

In those early days, politicians and government officials who’d never heard terms like “cytokine storm” and “RNA virus” were suddenly charged with explaining what was happening. The post The Dangers of “Do Your Own Research” and “Believe in Science” appeared first on DNA Science.

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Codon

MAY 11, 2023

It is used to prevent respiratory syncytial virus, or RSV, which causes about 60,000 hospitalizations in this age group each year. link ) A more representative human genome sequence, based on DNA from 47 ethnically diverse people, was published yesterday. Read more in WIRED. The vaccine was 82.6 People 2,000 years ago == people today.

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Codon

MAY 11, 2023

It is used to prevent respiratory syncytial virus, or RSV, which causes about 60,000 hospitalizations in this age group each year. link ) A more representative human genome sequence, based on DNA from 47 ethnically diverse people, was published yesterday. Read more in WIRED. The vaccine was 82.6 People 2,000 years ago == people today.

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PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! Looking back, which blog post was the most important? The Birth of DNA Science When St. The book that kickstarted DNA Science was The Forever Fix: Gene Therapy and the Boy Who Saved It.

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PLOS: DNA Science

FEBRUARY 20, 2025

Influenza incidence and severity are increasing , against a backdrop of novel drifts (small genetic changes) and shifts (larger changes) to the virus, all against a backdrop of novel infection pathways, such as birds to cows to people. The mRNA in COVID vaccines tells cells to produce the virus’s spike protein. Vaccines work!!!

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NIH Director's Blog: Drug Development

JANUARY 5, 2016

The RNA is preprogrammed to find a distinct short sequence of DNA and deliver the enzyme, which acts like a scalpel to slice the sequence out of the genome. But one end-of-the-year breakthrough list that really caught my eye was on the PLOS-hosted DNA Science Blog. It’s fast and pretty precise. 2015 Aug 29;386(9996):857-866. [3]

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Drug & Device Law

DECEMBER 19, 2022

vii) Changes solely affecting a natural product, a recombinant DNA-derived protein/polypeptide, or a complex or conjugate of a drug substance with a monoclonal antibody for the following: (A) Changes in the virus or adventitious agent removal or inactivation method(s); (B) Changes in the source material or cell line ; and.

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