PerkinElmer

AUGUST 13, 2020

The virus, which can cause a severe form of pneumonia and lead to acute respiratory distress, currently has no FDA-approved targeted therapeutic or vaccine. For this reason, researchers around the globe are scrambling to understand this novel virus and figure out its potentially targetable vulnerabilities.

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Advarra

JANUARY 11, 2024

In this blog, we examine how mRNA can impact cancer treatment, the unique challenges associated with working with mRNA, and strategies for researchers proposing mRNA-based cancer trials. The mRNA constructs used in COVID-19 vaccines, for example, direct cells to produce a version of the “spike” protein studding the surface of SARS-CoV-2.

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Vaccine Therapies Clinical Trials Small Molecule 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Promising new malaria vaccine for kids approved in Ghana. If you want to edit a gene inside of a neuron, what do you do? Green dots indicate neurons.

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Vaccine DNA Virus Engineering 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. Promising new malaria vaccine for kids approved in Ghana. If you want to edit a gene inside of a neuron, what do you do? Green dots indicate neurons.

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Vaccine DNA Virus Engineering 52

EG Life Sciences

FEBRUARY 15, 2023

The US Food and Drug Administration (FDA) approved around 26 novel drugs in 2022. Approval processes were slow in comparison to 2020 and 2021, where 53 and 50 approvals were achieved respectively. Going into the third year of the pandemic, we know that the virus still impacts industry operations.

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Drug Development FDA Approval Drugs Virus 52

Codon

APRIL 2, 2023

Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection. Read A really simple way to isolate AAVs, which are a type of virus often used to deliver gene therapies into cells. Only about 15% of antibodies actually neutralize the new variants. Ricciardi M.J. Gene Therapy.

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NIH Director's Blog: Drug Development

FEBRUARY 16, 2021

ACTIV-2 : A Phase 2/3 trial is enrolling adults with COVID-19 who are not hospitalized to evaluate the safety of multiple monoclonal antibodies (Lilly’s LY-CoV555, Brii Biosciences’s BRII-196 and BRII-198, and AstraZeneca’s AZD7442) used to block or neutralize the SARS-CoV-2 virus.

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Clinical Trials Trials Hospitals Vaccine 52

Codon

MAY 22, 2023

One paper estimates that the entirety of human-created mass (half of which is concrete) probably reached the total weight of Earth’s entire biomass — every tree, bacterium, virus, and whale — in 2020. Nature Communications. Read Engineered P. taiwanensis make aromatic chemicals with yields of 32.4% from glycerol.

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DNA Engineering Science Trials 63

Eye on FDA

AUGUST 8, 2022

In February 2020 I published a blog posting – Emerging Pathogens, Communications – that encapsulated my observations and learnings from my years work in the early years of the HIV/AIDS pandemic in the early 1980s. That means there is an increasing amount of virus out there. Source: CDC. But they are all viruses.

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Codon

MAY 22, 2023

One paper estimates that the entirety of human-created mass (half of which is concrete) probably reached the total weight of Earth’s entire biomass — every tree, bacterium, virus, and whale — in 2020. Nature Communications. Read Engineered P. taiwanensis make aromatic chemicals with yields of 32.4% from glycerol.

DNA 52

DNA Engineering Science Trials 52

Codon

MAY 18, 2023

Scientists removed Ashanti’s blood cells and inserted a functional copy of the ADA gene via a virus. Wilson then went on to isolate AAV9 for the first time, and it was later used to develop one of the first FDA-approved gene therapies: Zolgensma. link ) Yup, Elizabeth Holmes is going to prison. Maybe for real this time?

DNA 52

DNA Therapies Engineering Virus 52

Codon

MAY 18, 2023

Scientists removed Ashanti’s blood cells and inserted a functional copy of the ADA gene via a virus. Wilson then went on to isolate AAV9 for the first time, and it was later used to develop one of the first FDA-approved gene therapies: Zolgensma. link ) Yup, Elizabeth Holmes is going to prison. Maybe for real this time?

DNA 52

DNA Therapies Engineering Virus 52

SugarCone Biotech

MAY 28, 2019

So, another hypothesis is: PFIZER/BIONTECH’S VACCINE BNT162B2 PREVENTS SARS-COV2 VIRUS INFECTION. When we review the data we find our predictions are robustly supported: in every instance in which it has been studied BNT162b2 prevents SARS-COV2 virus infection and reduces viral spreading. Stay tuned. [1]

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Vaccine Clinical Trials Virus Science 52

PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! Looking back, which blog post was the most important? Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. That got me thinking.

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DNA Vaccine Science Therapies 105

Drug & Device Law

OCTOBER 13, 2023

We blogged on similar cases here , here , and here. The defendant has developed multiple drugs used to treat or prevent infection with the AIDS virus, including several containing tenofovir disoproxil fumarate (“TDF”) as an active ingredient. It makes no difference in our view that the FDA ultimately approved TAF-based drugs.

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