Codon

JULY 27, 2023

A LEGO robot , made by undergraduate students at Arizona State University, pours sucrose gradients (a tube with dense liquid at the bottom, and less dense liquid at the top), which are used to separate, say, proteins from RNA by spinning them really fast in centrifuges. How do transcription factors couple up with the correct RNA molecule?

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PerkinElmer

OCTOBER 26, 2021

Several studies have demonstrated the antiviral potential of certain classes of polyphenols against Epstein-Barr virus, 2 herpes simplex virus (HSV), 3 and other viruses causing respiratory tract-related infections. Cells were then infected with SARS-CoV-2 Spike-pseudotyped lentivirus or a control vesicular stomatitis virus G (VSVG).

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. If you want to edit a gene inside of a neuron, what do you do? These viruses enter the brain and deliver the gene-editing ingredients into neurons.

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Vaccine DNA Virus Engineering 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. If you want to edit a gene inside of a neuron, what do you do? These viruses enter the brain and deliver the gene-editing ingredients into neurons.

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Vaccine DNA Virus Engineering 52

Codon

APRIL 30, 2023

The company uses a modified virus to deliver multiple copies of the correct form of the beta-globin gene into a patient’s blood-producing stem cells. Read Ribosomes are able to build proteins because they contain a strand of RNA that imbues them with their catalytic power. It’s an easier way to get CRISPR into cells!

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Codon

APRIL 30, 2023

The company uses a modified virus to deliver multiple copies of the correct form of the beta-globin gene into a patient’s blood-producing stem cells. Read Ribosomes are able to build proteins because they contain a strand of RNA that imbues them with their catalytic power. It’s an easier way to get CRISPR into cells!

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Vaccine DNA Engineering RNA 52

Codon

JUNE 26, 2023

I pulled them from a 2011 blog post ( oH mY goD tHat’S nOt pEEr-ReVieWeD!!! ) A phage is a virus that infects bacteria. ” A blog post for the American Society for Microbiology : Early studies were promising, though experiments were often improperly designed by today's standards (i.e., Let’s be real. in Nature.

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DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

I pulled them from a 2011 blog post ( oH mY goD tHat’S nOt pEEr-ReVieWeD!!! ) A phage is a virus that infects bacteria. ” A blog post for the American Society for Microbiology : Early studies were promising, though experiments were often improperly designed by today's standards (i.e., Let’s be real. in Nature.

DNA 52

DNA Therapies Engineering Clinical Trials 52

PerkinElmer

JUNE 14, 2021

In October last year, remdesivir was the first drug approved by the FDA for treating the SARS-CoV-2 virus. Remdesivir was originally developed to treat hepatitis C and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection treatment for COVID-19.

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Codon

APRIL 9, 2023

Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. The new sequences might help de-extinction efforts.

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Therapies RNA Engineering Vaccine 52

PerkinElmer

AUGUST 18, 2020

The time sensitivity of virus research, combined with an increasing complexity of bench tasks, can make it helpful for labs to increase automaticity of experiments. For this reason, it might be necessary for research teams to screen many potential leads before they find one or two with strong potential. Sources Zhang et al.

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Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). On the surface, they hadn't deviated much from the early 2020s: a virus infected a cell and released the genetic therapy hidden within. But the differences racked up the closer one looked.

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Codon

MARCH 12, 2023

The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Base editor proteins were delivered into the mice using a virus, called AAV9. coli genes into a piece of simian virus DNA. Biology is a Burrito. 15 of 31.

DNA 52

DNA Engineering Therapies RNA 52

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. link ) INSPECTR is a diagnostic tool to detect tiny amounts of viral RNA at room temperature.

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DNA Bioinformatics Engineering Virus 52

PPD

NOVEMBER 8, 2022

In the third year of the COVID-19 pandemic, we also see the virus’s lingering effect on industry operations. Nine in 10 respondents reported that the pandemic altered their drug development strategy, with new priorities and collaborative approaches shaping how organizations proceed today.

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Codon

MAY 30, 2023

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Read more in Nature Methods.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

The researchers first compared the editing efficiency of different versions of IscB when coupled with 'ωRNA,' which guides the enzyme to the right spot on the DNA. A particular variant, named IscB*-ωRNA*, had the highest editing efficiency across multiple different sites in the genome. Read more in Nature Methods.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

APRIL 16, 2023

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Comparison of transformations for single-cell RNA-seq data.

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NIH Director's Blog: Drug Development

NOVEMBER 16, 2021

The SARS-CoV-2 virus encodes its own protease to help process a large virally-encoded polyprotein into smaller segments that it needs for its life cycle; a protease inhibitor drug can stop that from happening. The virus uses this enzyme to snip some longer viral proteins into shorter segments for use in replication.

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PLOS: DNA Science

OCTOBER 24, 2024

In those early days, politicians and government officials who’d never heard terms like “cytokine storm” and “RNA virus” were suddenly charged with explaining what was happening. Thankfully, informed voices emerged.

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Codon

FEBRUARY 19, 2025

ESM is a protein language model that captures certain aspects of protein structure and function, for example, but is blind to DNA or RNA-level features that drive cell behavior. Evo 2 was trained on DNA sequences but can make predictions about myriad aspects of biology, including RNA stability and protein structures.

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PLOS: DNA Science

FEBRUARY 20, 2025

Influenza incidence and severity are increasing , against a backdrop of novel drifts (small genetic changes) and shifts (larger changes) to the virus, all against a backdrop of novel infection pathways, such as birds to cows to people. The mRNA in COVID vaccines tells cells to produce the virus’s spike protein. Vaccines work!!!

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PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! Looking back, which blog post was the most important? Martin’s Press was about to publish my book about gene therapy in 2012, my agent urged me to start blogging. That got me thinking.

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NIH Director's Blog: Drug Development

JANUARY 5, 2016

This gene-editing system consists of a short segment of RNA that is attached to an enzyme. The RNA is preprogrammed to find a distinct short sequence of DNA and deliver the enzyme, which acts like a scalpel to slice the sequence out of the genome. 3] A Recombinant Vesicular Stomatitis Virus Ebola Vaccine — Preliminary Report.

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