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Transforming high-throughput screening with mass spectrometry

Drug Discovery World

Trapped ion mobility spectrometry: Improving the specificity of MALDI-MS-based HTS . The ability of MALDI-enabled TOF and QTOF systems to discriminate between analytes and sample matrix background components based on their specificity is, like other MS techniques, dependent upon the mass resolution. Weigt, C.A. Parrish, J.A.