Cell Biology DNA Therapies 
Drug Target Review
APRIL 9, 2024
For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX. Among other discoveries, the group developed inhibitors of the ATR kinase and showed their potential for cancer therapy.
DrugBank
JUNE 27, 2023
Their use, as well as their integration into other types of data, has enabled the development of more precise therapies. In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., by altering its accessibility to transcriptional machinery).
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Drug Target Review
OCTOBER 2, 2024
Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. However, cell-based therapies are intended to leverage those healthy cells via transplant to regenerate damaged tissue.
Broad Institute
NOVEMBER 21, 2024
Bernstein is also chair of the Department of Cancer Biology at Dana-Farber Cancer Institute, a professor in cell biology and pathology at Harvard Medical School, and holds the Richard and Nancy Lubin Family Chair. Inevitable progression Gliomas arise from glial cells, which protect and support a healthy nervous system. “So,
Broad Institute
OCTOBER 11, 2023
By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. The team found that deleting the gene Ptpn2 made tumors sensitive to PD-1 therapy, and they published their findings in Nature in 2017.
Codon
APRIL 2, 2023
But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. They tend to “group up” in cells. Molecular Systems Biology. Nature Microbiology. Meeussen J.V.W.
Codon
APRIL 30, 2023
2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. kilobases” of DNA into a plant genome. (My From Zhang et al. ” WTF?
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