Drug Target Review

DECEMBER 20, 2024

However, recent breakthroughs in AI, such as predictive modelling, clinical trial optimisation, and personalised medicine, have demonstrated its potential. At the heart of Unlearns approach is the use of AI to improve clinical trials, especially in phases two and three.

Clinical Trials

Drugs.com

JUNE 9, 2025

MONDAY, June 9, 2025 — Prompt treatment with a drug combo can effectively manage chronic kidney disease in people with type 2 diabetes, a new clinical trial shows. Patients prescribed the combination of finerenone and empagliflozin.

Treatment

thought leadership

JULY 20, 2025

Launching a clinical trial in Europe is a complex but rewarding endeavor, requiring careful navigation of regulatory frameworks, ethical requirements, and submission processes.

Clinical Trials

Quanticate

JULY 11, 2025

In clinical trials we all want faster results and adaptability. These goals can be achieved with trial standardisation and automation. Both approaches aim to streamline processes, but they differ in focus, speed, and flexibility.

Clinical Trials

Quanticate

JULY 3, 2025

Imagine being asked to join a clinical trial, but the nearest site is two hours away and you care for an elderly parent while working full-time. That’s the challenge decentralised clinical trials (DCTs) aim to solve. The burden of travel alone could be enough to say no.

Clinical Trials

BioPharma Drive: Drug Pricing

JUNE 23, 2025

While positive, results from a late-stage clinical trial appear to be raising questions about how useful the company’s version of psilocybin could be as a depression treatment.

Clinical Trials

H1 Blog

JULY 28, 2025

More Information, Same Enrollment Challenges In clinical trial feasibility, we face a counterintuitive reality: despite unprecedented access to healthcare professional data, identifying the right investigators and predicting enrollment success has become increasingly challenging.

Clinical Trials

Drugs.com

JUNE 6, 2025

FRIDAY, June 6, 2025 — A repurposed diabetes drug can be an effective tool against fatty liver disease, a new clinical trial has found. Dapagliflozin helped people reduce fat levels in their liver and avoid liver scarring that comes with the.

Disease

Science Daily: Pharmacology News

JUNE 30, 2025

clinical trials of pig kidney transplants begin, this breakthrough offers hope for overcoming the immune barrier that has long stood in the way of xenotransplantation. They discovered early signs of rejection within 10 days and pinpointed key immune players—like macrophages—driving the response.

Clinical Trials

Quanticate

AUGUST 1, 2025

Clinical trials have changed, and so have the expectations placed on the teams that run them. Trials move faster, are more fragmented, generate more data, and are under growing pressure to deliver real-time insights with audit-ready precision and regulatory oversight.

Clinical Trials

Fierce BioTech

JULY 22, 2025

Introduction | Decentralized Clinical Trials (DCTs) are transforming how we collect clinical data, but this evolution brings unprecedented challenges in data quality, complexity, and integration.

Clinical Trials

Drug Target Review

JULY 29, 2025

Effective financial management is a cornerstone in the success of clinical trials, which are integral to the advancement of drug discovery. As the pharmaceutical and biotech industries continue to evolve, clinical trials become more complex, and the importance of robust financial oversight has never been clearer.

Clinical Trials

Covalent Modifiers

JUNE 12, 2025

4c00622 The STAT family of transcription factors are important signaling hubs, with several of them, particularly STAT3, being emerging oncotargets already investigated in clinical trials. Keserű ACS Medicinal Chemistry Letters 2025 16 (6), 991-997 DOI: 10.1021/acsmedchemlett.4c00622

Small Molecule

Fierce BioTech

JUNE 24, 2025

Accelerate Clinical Trials with Methylation-Based ctDNA Detection Download now to learn from biopharma industry leaders about how methylation-based ctDNA detection for precise MRD and response monitoring can accelerate your clinical trials.

Clinical Trials

BioPharma Drive: Drug Pricing

JULY 9, 2025

Deep Dive Library Events Press Releases Topics Sign up Search Sign up Search Pharma Biotech FDA Clinical Trials Deals Drug Pricing Gene Therapy An article from Dive Brief Actithera draws new investors to radiopharma drug pitch The four-year-old biotech raised about $75 million in a Series A round that involved nine venture capital firms.

Drugs

FDA Law Blog: Drug Discovery

NOVEMBER 10, 2024

Each year, FDA selects a limited number of clinical trials to fund to help sponsors pursue development of medical products for rare diseases and advance their field. In October, FDA announced seven new clinical trial grants awarded in fiscal year (FY) 2024 – including one for a Phase 3 trial – totaling $17.2

Clinical Development

Covalent Modifiers

JULY 23, 2025

One agent in late-stage clinical trials, divarasib, has demonstrated robust overall response rates, in some cases greater than currently approved agents. Ongoing medicinal chemistry efforts across academia and industry have continued developing more potent and efficacious KRASG12C inhibitors.

FDA Approval

Covalent Modifiers

FEBRUARY 25, 2025

The investigational agent elironrasib is currently undergoing phase 1 clinical trials (NCT05462717, NCT06128551, NCT06162221), with preliminary data indicating clinical activity in patients who had progressed on first-generation inactive state-selective KRASG12C inhibitors.

Clinical Trials

Quanticate

JUNE 19, 2025

Clinical trials rely on comprehensive data collection to prove the investigational drug/device’s efficacy and safety, the Case Report Form (CRF), a structured document designed to record all trial-related data for each participant makes this possible.

Clinical Trials

Drug Patent Watch

DECEMBER 30, 2024

Types of Drug Applications The PMDA accepts three main types of drug applications: Investigational New Drug (IND) : Required for conducting clinical trials in Japan. Challenges and Opportunities Ethnic Bridging : Japan has historically required clinical trials to be conducted within the country to account for ethnic differences.

Drug Development

PPD

OCTOBER 31, 2024

Drug development The rising cost of clinical trials is the top challenge this year, due to increasingly complex protocol designs and difficult patient recruitment. The rising expense is driven by several factors, including increasingly complex protocol designs, difficulties with patient recruitment and the extended trial timelines.

Drug Development

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 An experimental drug might help people with uncontrolled high blood pressure, according to early clinical trial results.People taking lorundrostat experienced twice the decline in their systolic blood pressure than people t.

Clinical Trials

Drug Target Review

MARCH 24, 2025

Today, researchers must progress through multiple stages of testing: starting with in vitro studies (experiments in test tubes or petri dishes), they then move to animal studies (preclinical testing) before finally advancing to human clinical trials.

Clinical Trials

Crucial Data Solutions

JUNE 16, 2025

Serious adverse events (SAEs) are among the most critical data points collected during a clinical trial. The post How EDC-Based SAE Reporting Reduces Time to Detection and Response in Clinical Trials appeared first on Crucial Data Solutions. The timeliness and accuracy.

Clinical Trials

Covalent Modifiers

MAY 18, 2025

Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is currently being explored in a clinical trial for Parkinsons disease. However, the molecular basis for specific inhibition of USP30 by small molecules has remained elusive.

Engineering

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 Testing positive for leukemia actually saved the life of 51-year-old Jan Leahy, a business process owner from Wimbledon, England.Leahy benefitted from a clinical trial evaluating a new bone marrow test that can detect a p.

Clinical Trials

Chemical Biology and Drug Design

JUNE 19, 2025

The presence of thienopyrimidine derivatives in several FDA-approved drugs and clinical trial candidates underscores their therapeutic potential and safety profile. The review elaborates on the primary approach for synthesis of thienopyrimidines, using thiophene derivatives or pyrimidine analogues.

FDA Approval

Antidote

JUNE 23, 2025

In clinical trial patient recruitment, it’s tempting to focus on the numbers we can easily track: impressions, clicks, pre-screener completions. But those metrics don’t enroll patients. Real recruitment success is driven by empathy, strategy, and seamless execution.

Clinical Trials

Drug Patent Watch

DECEMBER 9, 2024

Robust Clinical Trial Design : Clinical trials for biosimilars should be designed to demonstrate equivalence or non-inferiority to the reference product. This involves working closely with regulators to ensure that the analytical characterization and clinical trial design meet the necessary standards for approval.

Biosimilars

PPD

NOVEMBER 11, 2024

Accelerate your drug development and clinical trial goals and benefit from our 360° CDMO and CRO solutions and expertise. Partner with us The post Redefining Acceleration of the Drug Development Journey appeared first on PPD.

Drug Development

Quanticate

JUNE 13, 2025

Clinical research generates vast amounts of diverse data from laboratory tests, patients, medical equipment, and outside sources. By organising and analysing this information, researchers can extract actionable insights that improve patient outcomes, data accuracy, drug efficacy and speed up trials.

Clinical Trials

Drug Target Review

APRIL 7, 2025

A surrogate endpoint is a marker used in clinical trials as a substitute for a direct clinical outcome. Diagnostic biomarkers typically confirm or establish a diagnosis and are often used in selecting patient populations for clinical trials.

Clinical Development

Drug Patent Watch

JUNE 13, 2025

According to our analysis of clinical trial listings, the following industries are leading the charge in seeking legal counsel: Biotech: With a 25% increase in clinical trial listings over the past year, biotech companies are racing to secure patents and protect their intellectual property.

Clinical Trials

Crown Bioscience

AUGUST 5, 2025

These structures hold the promise of reducing the high failure rate seen in clinical trials by providing more accurate preclinical testing, thus potentially saving time and resources while enhancing patient safety.

Drug Development