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Human tumor response to novel natural product compounds using the POAI biobank and active machine learning

Predictive Oncology

In this white paper, Predictive Oncology (POAI) highlights a recent successful project in partnership with the University of Michigan Natural Products Discovery Core (NPDC) through the ACE program. Several NPDC compounds demonstrated efficacy across multiple tumor types and are now well positioned for further development.

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Protein Science & Structural Biology

Sygnature Discovery

Significant expertise in membrane protein production. Compound Screening Fragment Based Drug Discovery supported by Crystallography or SPR & MST. Covalent compound binding by mass spectrometry. Designed for end use. HEK, CHO, Insect, E.coli from mL to 25L scale. X-Ray Crystallography, Cryo-EM and NMR.

Science 52
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Compound Management

Sygnature Discovery

Individual labware capacities can be increased or decreased based on requirement Matrix 1.4ml tubes/ Fluid X 1mL Tubes 135,000 SBS microplates 6,500 Compound Handling: The Tecan Fluent liquid handler enhances productivity and precision through state-of-the-art automation.

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Target-directed cancer: protein-ligand interactions  

Drug Target Review

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. For example, in the screening stage of a project we are trying to find initial starting points for optimisation by our medicinal and computational chemistry colleagues.

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ChEMBL 34 is out!

The ChEMBL-og

A significant effort has been made to correctly map the drug form of the EMA data by manually inspecting different EMA sources of information, such as the Product Information (Annex I: Summary of Product Characteristics and Annex III: Labelling and Package Leaflet) and/or Assessment Report, where available. University of Dundee: T.

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A trusted partner in drug discovery: Viral Patel’s 20-year journey with mosquito®

sptlabtech

These capabilities make it an invaluable tool for applications ranging from compound screening and medicinal chemistry to molecular and structural biology. His valuable insights have been incorporated into product development, refining its capabilities to continue to meet real-world research challenges.

Drugs 59