Disease DNA Protein Expression 
LifeSciVC
JUNE 12, 2025
Josh’s work at the Marine Biological Laboratory unlocked the potential of utilizing an endogenous protein to make a single alphabet change on RNA (RNA editing), a process that was precise, reversible and had druglike characteristics. This concept of effecting a protein change.
Codon
DECEMBER 10, 2023
Predictive Models A “ sequence-to-function ” predictive model – an algorithm that determines a protein’s likely function solely by looking at the DNA sequence encoding it – is the natural successor to AlphaFold2. A predictive model for sequence-to-expression would raise the “hit” rates.
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DrugBank
JULY 24, 2024
This is a game-changer, especially in the fight against cancer and other complex diseases. These multifunctional small molecules are like tiny spies, hijacking the body’s natural protein degradation system to remove unwanted proteins. This can potentially correct the root causes of some diseases at the genetic level.
Codon
DECEMBER 10, 2023
Predictive Models A “ sequence-to-function ” predictive model – an algorithm that determines a protein’s likely function solely by looking at the DNA sequence encoding it – is the natural successor to AlphaFold2. A predictive model for sequence-to-expression would raise the “hit” rates.
Conversations in Drug Development Trends
AUGUST 14, 2024
Heterogeneity in Hematological Cancers Due to their disease heterogeneity, hematological cancers are well-suited for personalized approaches. Molecular Biomarkers : Encompass various molecules, such as RNA and metabolites, to reflect the physiological state of the cells and their disease pathways.
Drug Target Review
MAY 4, 2023
These studies are conducted by comparing the genomes of large populations to find variants that occur more often in those with a specific disease or trait. These studies are conducted by comparing the genomes of large populations to find variants that occur more often in those with a specific disease or trait. “A
The Pharma Data
MARCH 30, 2021
Fibroblast activation protein (FAP) is a cell-surface protein expressed at low levels in most normal adult tissues, but over-expressed in common cancers, particularly on cancer-associated fibroblasts that form the tumor stroma, which is essential for growth 1 ,2 ,3 ,4.
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