Remove DNA Remove Engineering Remove Protein Expression
article thumbnail

Building Korro Bio: A CEO’s Perspective on Innovation and Risk Management

LifeSciVC

Josh’s work at the Marine Biological Laboratory unlocked the potential of utilizing an endogenous protein to make a single alphabet change on RNA (RNA editing), a process that was precise, reversible and had druglike characteristics. We intended to learn from nature (genetics) and use pharmaceuticals properties to drive patient benefit.

RNA 68
article thumbnail

What Biology Can Learn from Physics

Codon

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

What Biology Can Learn from Physics

Codon

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

article thumbnail

Key considerations before commencing cell line development

Drug Target Review

This selectable marker enables the identification of cells which have taken up the GOIs and aids the initial selection of recombinant protein expressing cell lines. They work in the following way: the genes in an expression vector are flanked by inverted terminal repeat sequences (ITRs) to which a specific transposase enzyme can bind.

article thumbnail

Rapid delivery of toxicological material

Drug Target Review

The current landscape of protein drug development is characterised by accelerated timelines where new drugs are approved in months rather than years. For example, advances in media and feeds have contributed to higher cell protein expression by optimising nutrient availability and reducing accumulation of waste products within a culture.

article thumbnail

Five Promising Treatment Areas in Early-Phase Drug Development in 2024

Alta Sciences

Several viral vectors are being used currently, in addition to non-viral vectors, such as oligonucleotides, naked DNA, and lipoplexes and polyplexes. They work by binding to specific sequences of nucleotides present within the mRNA structure and can induce mechanisms that either decrease, restore, or modify protein expression.

article thumbnail

The Magic of Fast Feedback Loops

Codon

In the four years I’ve been working as a machine learning engineer at Dyno Therapeutics , a biotechnology company in Boston, I’ve become increasingly convinced that biologists have an almost masochistic tolerance for difficult and protracted work. One such opportunity, for example, is in protein expression.