Thu.Jun 13, 2024

article thumbnail

Metformin slows cancer growth using microRNAs, study finds

Drug Discovery World

Australian researchers have analysed how an antidiabetic treatment could help control the growth of tumours, potentially paving the way for the design of better cancer treatments. The new study investigated what happens when metformin, a type 2 diabetes medication, is used to treat colorectal cancer cells, in the process demonstrating that it could be exploited to develop new cancer therapies.

RNA 130
article thumbnail

Scientists preserve DNA in an amber-like polymer

Science Daily: Pharmacology News

With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.

DNA 130
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

Webinar: The latest innovative solutions in biotherapeutic manufacturing

Drug Discovery World

Join DDW and Thermo Fisher Scientific on 20 June, 11AM EDT/4PM BST, for an exclusive webinar, ‘ Advancing biotherapy manufacturing: innovative strategies for residual DNA and viral titre quantitation using dPCR ’. This free event will feature insight from Thermo Fisher Scientific’s Jonas Buege, Senior Manager, Product Management, as well as Viki Mahen, Scientist III, Molecular Biology.

DNA 130
article thumbnail

Studies uncover the critical role of sleep in the formation of memories

Science Daily: Pharmacology News

A lack of sleep can make it extraordinarily difficult to retain information. Two new studies uncover why this is and what is happening inside the brain during sleep and sleep deprivation to help or harm the formation of memories.

128
128
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Scrub-a-Dub-Dub: FTC is Cleansing the Orange Book of Device Patents

FDA Law Blog: Biosimilars

By Sara W. Koblitz — As we have noted for the last year or so, the FTC has been on a mission to clean up the Orange Book by removing what it deems to be “improper” patents. The FTC has put out policy statements, challenged patent listings, tapped Congress, appeared on talk shows, and filed amicus briefs all in the span of the last 8 months. It seems like all that work is paying off.

FDA 116
article thumbnail

Are mixed emotions real? New research says yes

Science Daily: Pharmacology News

Neuroscientists found that brains display distinct neural activity when experiencing emotions such as bitter-sweetness. The advance could help solve a longstanding scientific debate: whether 'mixed emotions' arise from unique activity in the brain, or if we're just flip-flopping back and forth between positive and negative feelings.

Research 116

More Trending

article thumbnail

Pair plasmas found in deep space can now be generated in the lab

Science Daily: Pharmacology News

Researchers have experimentally generated high-density relativistic electron-positron pair-plasma beams by producing two to three orders of magnitude more pairs than previously reported.

Research 108
article thumbnail

Secondary Tumors After CAR-T Cancer Therapies Are Rare: Study

Drugs.com

THURSDAY, June 13, 2024 -- CAR-T cell therapy to treat blood cancers is safer than previously thought, with little risk that the immunotherapy will create secondary cancers, a new study finds.The U.S. Food and Drug Administration issued a warning.

Therapies 110
article thumbnail

The rotation of Earth's inner core has slowed, new study confirms

Science Daily: Pharmacology News

The new study provides unambiguous evidence that the inner core began to decrease its speed around 2010, moving slower than the Earth's surface.

118
118
article thumbnail

Nearly 1 in 4 People With Bipolar Disorder Achieve Complete Mental Health

Drugs.com

THURSDAY, June 13, 2024 -- Bipolar disorder doesn’t have to be a lifelong challenge, a new study says.Nearly 1 in 4 people with bipolar disorder wind up achieving complete mental health, researchers found.Further, more than 2 in 5 become free from b.

Research 106
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Dolphins with elevated mercury levels in Florida and Georgia

Science Daily: Pharmacology News

Scientists found elevated mercury levels in dolphins in the U.S. Southeast. The highest levels were found in dolphins in Florida's St. Joseph and Choctawhatchee Bays. Researchers study dolphins because they are considered a sentinel species for oceans and human health. Like us, they are high up in the food chain, live long lives, and share certain physiological traits.

Research 105
article thumbnail

J&J Settles Talcum Powder Lawsuits From States for $700 Million

Drugs.com

THURSDAY, June 13, 2024 -- Johnson & Johnson will pay $700 million to settle claims from 42 states and the District of Columbia that the company continued to market its talcum powder products even as evidence tied them to a heightened risk for.

article thumbnail

Ancient ocean slowdown warns of future climate chaos

Science Daily: Pharmacology News

When it comes to the ocean's response to global warming, we're not in entirely uncharted waters. A new study shows that episodes of extreme heat in Earth's past caused the exchange of waters from the surface to the deep ocean to decline.

101
101
article thumbnail

Diphtheria-Like Germ Can Be Passed Between People and Pets

Drugs.com

THURSDAY, June 13, 2024 -- The first two cases of a diphtheria-like illness being transmitted in the United States between people and their pets have been reported in Utah and Colorado. The respiratory illnesses occurred in 2022 and 2023 and.

98
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Nanosized blocks spontaneously assemble in water to create tiny floating checkerboards

Science Daily: Pharmacology News

Researchers have engineered nanosized cubes that spontaneously form a two-dimensional checkerboard pattern when dropped on the surface of water. The work presents a simple approach to create complex nanostructures through a technique called self-assembly.

article thumbnail

Climate Change Brings Worse Heart Health to People Worldwide

Drugs.com

THURSDAY, June 13, 2024 -- Climate change is harming the heart health of people around the world, a new review warns.Extreme temperatures, hurricanes and other dangerous weather events all contribute to an increased risk of heart disease and.

Disease 98
article thumbnail

Pfizer setback brings questions for Duchenne gene therapy ahead of Sarepta decision

BioPharma Drive: Drug Pricing

The failure of another trial adds to uncertainty around the benefits of the gene-based treatments, though industry analysts still expect Sarepta’s Elevidys’ to be unaffected.

article thumbnail

Could Moms of Low-Birth-Weight Babies Face Higher Dementia Risk Later?

Drugs.com

THURSDAY, June 13, 2024 -- Women who deliver low-birth-weight babies could be more likely to have memory and thinking problems later in life, a new study warns.As seniors, these women had brain test scores that indicated one to two years of.

98
article thumbnail

6,000 years ago, men and women had equal access to resources

Science Daily: Pharmacology News

Using isotope geochemistry, scientists have uncovered new information about the Barmaz necropolis in Valais (Switzerland): 14% of the people buried 6,000 years ago at this site were not locals. What's more, the study suggests that this Middle Neolithic agropastoral society -- one of the oldest known in the western part of Switzerland -- was relatively egalitarian.

88
article thumbnail

People Are Living Longer With Type 1 Diabetes

Drugs.com

THURSDAY, June 13, 2024 -- People with type 1 diabetes are 25% less likely to die early now than they were in 1990, a new global tally finds, and the number of people who've lived into their senior years with the autoimmune illness keeps.

98
article thumbnail

Paleontology: New fossil fish genus discovered

Science Daily: Pharmacology News

Paleontologists have identified a new genus of fossil goby, revealing evolutionary secrets of a lineage that stretches back millions of years.

91
article thumbnail

Supreme Court Rejects Case That Would Have Curbed Access to Abortion Drug

Drugs.com

THURSDAY, June 13, 2024 -- The U.S. Supreme Court on Thursday threw out a case that aimed to curb access to the controversial abortion drug mifepristone, saying the plaintiffs who brought the case to the court had no legal standing to do so.In a.

Drugs 98
article thumbnail

Moderna says next-gen COVID shot effective in study

BioPharma Drive: Drug Pricing

Trial data suggest the shot — an important component of an upcoming combination inoculation — has proven at least as effective, and in some cases superior, to the company’s initial COVID vaccine.

Vaccine 85
article thumbnail

As Women Gain More Equality, Men Eat More Meat

Drugs.com

THURSDAY, June 13, 2024 -- In countries where gender equality is becoming more of a reality, men's meat consumption tends to rise relative to women's, a new study shows.The phenomenon was seen mainly in richer countries in North America and Europe.

98
article thumbnail

From Nanotechnology to Gene Therapy: Innovations in Drug Delivery

DrugBank

The landscape of medicine is constantly evolving, and one of the most exciting areas of progress lies in the development of advanced drug delivery systems. These innovative technologies are changing how medications reach their targets within the body, leading to more effective treatments with fewer side effects. This is great news for patients across various medical fields, promising better outcomes and improved quality of life.

article thumbnail

Versant debuts biotech working on ‘anger management for the immune system’

BioPharma Drive: Drug Pricing

Investor enthusiasm for precision immunology medicines is providing a tailwind for Santa Ana Therapeutics, a new startup backed by Versant, GV and a16z, among others.

73
article thumbnail

Robotic Procedure Helps Treat Macular Degeneration

Drugs.com

THURSDAY, June 12, 2024 -- Robot-guided radiation therapy can improve treatment for age-related macular degeneration, the leading cause of vision loss and blindness among American seniors, a new study shows.Precisely targeted radiation treatment.

article thumbnail

Drug Discovery Industry Roundup with Barry Bunin — June, 13 2024

Collaborative Drug

F.D.A. Approval of New Alzheimer’s Drug? Can Weight Loss Drugs Reduce Hear Attacks? How Successful are AI-Discovered Drugs in Clinical Trials?

article thumbnail

Pairing Up Shelter Dogs Can Raise Their Odds for Adoption

Drugs.com

THURSDAY, June 13, 2024 -- Shelter dogs do better with a buddy, a new study finds.Dogs show fewer signs of stress and are adopted more quickly if paired up with another canine rather than housed by themselves, researchers found.“Despite being a s.

article thumbnail

Dopamine linked to mentalizing abilities

Science Daily: Pharmacology News

A link between the neurotransmitter dopamine and the mentalizing abilities of healthy people has been identified.

82
article thumbnail

What is Clinical Data Management?

Quanticate

The life sciences industry is one of the most rigorously regulated sectors globally, prioritising patient safety during clinical trials and post-marketing phases. All trials must comply with country-specific regulations set by regulatory bodies. When relying on clinical research to introduce new products to the market, adhering to regulations like Good Laboratory Practice (GLP), Good Clinical Practice (GCP), and CFR Part 11 is mandatory.

article thumbnail

Behind the Oncology Research : An Interview Between Robert Szulkin and Jana de Boniface

Cytel

Welcome to our interview with Dr. Jana de Boniface, a renowned surgeon and researcher specializing in breast cancer. In this conversation, we delve into her inspiring journey, groundbreaking research, and collaborative efforts that have led to significant advancements in breast cancer treatment.

article thumbnail

Understanding the Limitations of Off-the-Shelf Foundation Models in Preclinical R&D

BenchSci

In recent years, artificial intelligence (AI) has reshaped numerous industries, enhancing innovation and efficiency through task automation and data analysis. This transformation is fueled, in part, by the rise of off-the-shelf foundation models, or large language models (LLMs), like OpenAI's GPT series, BigScience’s BLOOM, and Google's LaMDA. These powerful, pre-trained models, readily available through open-source or commercial platforms, have revolutionized natural language processing and und

Disease 59
article thumbnail

New patent for Astrazeneca Ab drug XIGDUO XR

Drug Patent Watch

Annual Drug Patent Expirations for XIGDUO+XR Xigduo Xr is a drug marketed by Astrazeneca Ab and is included in one NDA. It is available from two suppliers.

Drugs 59