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Case Study: How Altasciences Overcame Pharmacological Challenges in a GLP-1 IND-Enabling Study pmjackson Thu, 04/24/2025 - 21:43 For emerging therapies with pronounced pharmacological effects, thoughtful study design is critical to ensuring reliable and interpretable data. In preclinical studies , the same effects that make GLP-1 receptor agonists (RA) effective treatments for appetite suppression and weight loss, can often become obstaclescomplicating the evaluation of toxicological outcomes du
"Warning: Are You About to Fall into the Generic Drug Development Trap? As a seasoned pharma professional, I've seen it time and time again: promising generic drug candidates that fail to deliver due to avoidable pitfalls. Don't let this happen to you. Check out our latest blog post to learn how to avoid the most common mistakes in generic drug development: [link] From patent strategies to regulatory hurdles, we break down the key takeaways to help you navigate the complex landscape of gene
After a blockbuster inaugural event and tremendous feedback from attendees, were excited to announce that the Drug Channels Leadership Forum (DCLF) returns on March 1618, 2026 , at the Turnberry Resort & Spa in Miami. This one-of-a-kind, off-the-record event convenes senior leaders across the drug channel to address todays most pressing industry issues.
Mind blanking is a common experience with a wide variety of definitions ranging from feeling 'drowsy' to 'a complete absence of conscious awareness.' Neuroscientists and philosophers compile what we know about mind blanking, including insights from their own work observing people's brain activity.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
THURSDAY, April 24, 2025 Patients who legitimately need opioid painkillers are finding it more difficult to get the meds they need, due to guardrails established in response to the U.S. opioid crisis, a new study says.Doctors who treat patients i.
Humans are better than current AI models at interpreting social interactions and understanding social dynamics in moving scenes. Researchers believe this is because AI neural networks were inspired by the infrastructure of the part of the brain that processes static images, which is different from the area of the brain that processes dynamic social scenes.
The drugmaker absorbed additional tariff-related costs in the first quarter, but has taken steps to lower the financial impact it’ll have for the rest of the year and beyond.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
The drugmaker absorbed additional tariff-related costs in the first quarter, but has taken steps to lower the financial impact it’ll have for the rest of the year and beyond.
'Cold' tumors are resistant to common immunotherapies. Researchers have uncovered a master regulator that can be manipulated to prevent tumor growth in mice.
THURSDAY, April 24, 2025 -- Singing can be a balm for the soul, but does it still soothe if a person is singing alone in a virtual crowd?Yes, says a pandemic-era study that tested whether seniors received any emotional or mental benefit from.
In a landmark clinical trial people at risk for Alzheimer's who exercised at low or moderate-high intensity showed less cognitive decline when compared to those receiving usual care.
THURSDAY, April 24, 2025 A quick spray of medication might seem like an easy way to get thicker hair, but some people say one sold online has left them battling sexual side effects, depression and even thoughts of suicide.Now, the U.S. Food and D.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
A 113-million-year-old hell ant that once lived in northeastern Brazil is now the oldest ant specimen known to science, finds a new report. The hell ant, which was preserved in limestone, is a member of Haidomyrmecinae -- an extinct subfamily that only lived during the Cretaceous period. These ants had highly specialized, scythe-like jaws that they likely used to pin or impale prey.
THURSDAY, April 24, 2025 -- The U.S. Department of Health and Human Services and the U.S. Food and Drug Administration have released further details of their plans to remove all petroleum-based synthetic dyes from the nation's food supply."Today.
An international team has explored how in future aerial robots could process construction materials precisely in the air -- an approach with great potential for difficult-to-access locations or work at great heights. The flying robots are not intended to replace existing systems on the ground, but rather to complement them in a targeted manner for repairs or in disaster areas, for instance.
THURSDAY, April 24, 2025 -- Women suffering from urinary incontinence might have a greater risk of heart disease, a new study says.Women who struggle with bladder control are more likely to have risk factors associated with heart health problems.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Researchers in the field of exposomics explain how cutting-edge technologies are unlocking this biological archive, ushering in a new era of disease prevention and personalized medicine.
The biotech is using AI and a trove of health data to better understand why certain conditions progress and intervene beforehand with a targeted medication.
Using the James Webb Space Telescope (JWST), scientists analyzed far-away bodies -- known as Trans-Neptunian Objects (TNOs) -- and found varying traces of methanol. The discoveries are helping them better classify different TNOs and understand the complex chemical reactions in space that may relate to the formation of our solar system and the origin of life.
THURSDAY, April 24, 2025 The United States is now experiencing its largest measles outbreak since the disease was declared eliminated in 2000, federal scientists confirmed this week.At least 800 measles cases have been reported nationwide this y.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Researchers have long recognized that quantum communication systems would transmit quantum information more faithfully and be impervious to certain forms of error if nonlinear optical processes were used. However, past efforts at incorporating such processes could not operate with the extremely low light levels required for quantum communication.
Net sales of Cobenfy, whose success is imperative for Bristol Myers, totaled $27 million in the first quarter, handily beating Wall Street expectations.
Combining two different kinds of signals could help engineers build prosthetic limbs that better reproduce natural movements, according to a new study. A combination of electromyography and force myography is more accurate at predicting hand movements than either method by itself.
The company reiterated its financial outlook for the year but is struggling to predict the likely impact of pharmaceutical tariffs given their “speculative” nature, its CFO told analysts.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Researchers developed a more efficient way to control the outputs of a large language model, guiding it to generate text that adheres to a certain structure, like a programming language, and remains error free.
THURSDAY, April 24, 2025 (HeathDay News) -- Doctors might be able to use a new scoring system to avoid unnecessary surgery to prevent strokes, a new study shows.Patients with clogged arteries often undergo surgery to reopen blood vessels choked by.
The young biotech, sprung out of a Versant incubator in Switzerland, has a pair of antibody drugs it claims to have the potential to treat multiple autoimmune conditions.
THURSDAY, April 24, 2025 (Health Day News) Fewer babies are being born in the U.S., and experts are worried what that portends for the future.The number of babies born in the U.S. rose slightly in 2024, the fertility rate remains below levels n.
Epigenetics , the study of changes in gene activity that occur without altering the DNA sequence, has revolutionized our understanding of gene expression regulation. This dynamic regulatory network determines whether genes are turned on or off, ultimately influencing cellular identity and disease progression. Epigenetic changes are governed by chemical modifications such as DNA methylation, histone modifications, RNA-mediated processes, and all-controlling chromatin structure and gene accessibil
THURSDAY, April 24, 2025 -- The effects of COVID-19 continue to reverberate in the cancer risk factors of Americans, a new American Cancer Society (ACS) study says.Screening for breast and colon cancers has rebounded after decreasing or stalling.
Clinical trials are the heartbeat of medical innovationbut too often, recruitment becomes the bottleneck that stalls progress. While sponsors continue to invest millions into recruitment, 80% of clinical trials still fail to meet enrollment timelines. Why? Because the traditional strategies many rely on simply werent built for todays complex landscape.
THURSDAY, April 24, 2025 -- Treating anemia during pregnancy might lower the risk of heart defects in newborns, a new study says.Women with anemia in early pregnancy have a 47% increased risk of giving birth to a child with a heart defect.
Female bonobos team up to suppress male aggression against them -- the first evidence of animals deploying this strategy. In 85% of observed coalitions, females collectively targeted males, forcing them into submission and shaping the group's dominance hierarchy. This is the first study to test drivers of female dominance in wild bonobos. The study examined 30 years of demographic and behavioral data across six wild bonobo communities.
Noah A. Springer, Patrick R. A. Zanon, Amirhossein Taghavi, Kisu Sung, Matthew D. Disney bioRxiv 2025.04.22.649986; doi: [link] RNA is a key drug target that can be modulated by small molecules, however covalent binders of RNA remain largely unexplored. Using a high-throughput mass spectrometry screen of 2,000 electrophilic compounds, we identified ligands that react with RNA in a binding-dependent manner.
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