Tue.Feb 25, 2025

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Giant ice bulldozers: How ancient glaciers helped life evolve

Science Daily: Pharmacology News

New research has revealed how massive ancient glaciers acted like giant bulldozers, reshaping Earth's surface and paving the way for complex life to flourish. By chemically analyzing crystals in ancient rocks, the researchers discovered that as glaciers carved through the landscape, they scraped deep into the Earth's crust, releasing key minerals that altered ocean chemistry.

Research 294
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Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers

Covalent Modifiers

James Cregg, Kristof Pota, Aidan C. A. Tomlinson, Jason Yano, Abby Marquez, Yang Liu, Christopher J. Schulze, Kyle J. Seamon, Matthew Holderfield, Xing Wei, Yongxian Zhuang, Yu Chi Yang, Jingjing Jiang, Yue Huang, Ruiping Zhao, Yun Ling, Zhican Wang, Michael Flagella, Zhengping Wang, Mallika Singh, John E. Knox, Robert Nichols, David Wildes, Jacqueline A.

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Clashing with classmates: Off-putting traits spark enemy relationships

Science Daily: Pharmacology News

Making enemies isn't random. Traits like emotional instability, aggression, and disruptive behavior early in life can lead to antagonistic relationships. Research on students aged 9-14 found that negative behaviors, such as lack of empathy, increase the likelihood of mutual antagonisms, a pattern seen across genders and school levels. Emotionally struggling students were 35% more likely to develop enemies, showing that how we manage emotions and interact with others early on can have lasting soc

Research 252
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Regeneron gene therapy helps deaf children hear in small study

BioPharma Drive: Drug Pricing

Ten of 11 children born with a rare form of congenital hearing loss experienced improvements after receiving the company’s treatment, new data show.

Therapies 325
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Novel bone marrow transplant can cure sickle cell disease, study suggests

Science Daily: Pharmacology News

A bone marrow transplant process is safe and curative for adults with sickle cell disease, according to results of a trial completed at about 20 cancer centers.

Disease 309

More Trending

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Hormones may have therapeutic potential to prevent wrinkles, hair graying

Science Daily: Pharmacology News

Hormones may be leveraged to treat and prevent signs of aging such as wrinkles and hair graying, according to a new study.

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Listeria Outbreak From Frozen Shakes Kills 12, Sickens 38

Drugs.com

TUESDAY, Feb. 25, 2025 -- A listeria outbreak tied to frozen shakes served in hospitals and long-term care facilities has sickened at least 38 people and killed 12, according to the U.S. Food and Drug Administration (FDA). The shakes, which are not.

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'Smarts' count: Evolution of intelligence

Science Daily: Pharmacology News

The Beatles said it best: Love is all you need. And according to new research, the same may be true in the animal kingdom. Well, at least for mosquitofish -- a matchstick-sized fish endemic to Central America and now found globally. According to the scientists, male mosquitofish possess impressive problem-solving skills and can successfully navigate mazes and other tests.

Research 299
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Night Shift Workers Might Lower Cancer Risk With Melatonin

Drugs.com

TUESDAY, Feb. 25, 2025 -- Night shift workers face an increased risk of cancer, as their disrupted sleep cycle causes wear and tear on their DNA.But taking melatonin might help ward off this risk, a new study suggests.Folks on the night shift.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Why is Mars red? Scientists may finally have the answer

Science Daily: Pharmacology News

A new study shows a water-rich mineral could explain the planet's color -- and hint at its wetter, more habitable past.

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Antidepressants Might Accelerate Dementia Decline

Drugs.com

TUESDAY, Feb. 25, 2025 (HealthDay news) -- Antidepressants are frequently prescribed to people with dementia for symptoms like anxiety, depression, aggressiveness and sleeplessness.But a specific class of antidepressant medications -- selective.

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ESO observations help almost fully rule out 2024 YR4 asteroid impact

Science Daily: Pharmacology News

New observations of 2024 YR4 conducted with the European Southern Observatory's Very Large Telescope (ESO's VLT) and facilities around the world have all but ruled out an impact of the asteroid with our planet. The asteroid has been closely monitored in the past couple of months as its odds of impacting Earth in 2032 rose to around 3%, the highest impact probability ever reached for a sizable asteroid.

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Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display

Covalent Modifiers

Sijie Wang, Franco F. Faucher, Matilde Bertolini, Heeyoung Kim, Bingchen Yu, Li Cao, Katharina Roeltgen, Scott Lovell, Varun Shanker, Scott D. Boyd, Lei Wang, Ralf Bartenschlager, and Matthew Bogyo Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.4c15843 Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential to make highly selective binding interactions with targets.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Biological organ ages predict disease risk decades in advance

Science Daily: Pharmacology News

Our organs age at different rates, and a blood test determining how much they've each aged could predict the risk of conditions like lung cancer and heart disease decades later, finds a new study.

Disease 290
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More ER Docs Prescribing Meds To Fight Opioid Addiction

Drugs.com

TUESDAY, Feb. 25, 2025 -- More emergency room doctors in California are prescribing the anti-addiction medication buprenorphine, contributing to the states battle against the U.S. opioid epidemic, a new study suggests.About 16% of scrips written f.

Doctors 242
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Mimicking shark skin to create clean cutting boards

Science Daily: Pharmacology News

Keeping work surfaces clean during meat processing is a challenge, and now researchers deliver key insights into a solution that could change the current practice altogether: Instead of working to prevent bacteria buildup, they created surfaces that stop bacteria from attaching in the first place. Using lasers to etch and alter the surface of the metal, the team was able to create micro- or nanoscale textures that make it difficult for microbial cells to attach to the surface.

Research 177
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Most Americans Don’t Know These Heart Disease Risks, Survey Shows

Drugs.com

TUESDAY, Feb. 25, 2025 -- Many Americans don't realize how everyday habits and overlooked health issues can increase their risk for heart disease, according to a new Cleveland Clinic survey. The nationwide survey found numerous gaps in heart health.

Disease 240
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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New study reveals Neanderthals experienced population crash 110,000 years ago

Science Daily: Pharmacology News

A new study suggests that Neanderthals experienced a dramatic loss of genetic variation during the course of their evolution, foreshadowing their eventual extinction. Examination of semicircular canals of ear shows Neanderthals experienced 'bottleneck' event where physical and genetic variation was lost.

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Boston Scientific Recalls Accolade Pacemaker Devices

Drugs.com

TUESDAY, Feb. 25, 2025 -- Boston Scientific has issued a recall of Accolade pacemaker devices, according to a safety communication from the U.S. Food and Drug Administration.The Accolade devices under recall include the Accolade, Proponent.

Drugs 208
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First female runner could soon break the 4-minute-mile barrier

Science Daily: Pharmacology News

With ideal conditions and strategic pacing and drafting, Kenyan Faith Kipyegon is on the brink of hitting the fabled track and field milestone, a new study suggests. The authors are now calling for a staged 'Breaking 4' event to help her do it.

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Gynecological Problems Risk Heart, Brain Health

Drugs.com

TUESDAY, Feb. 25, 2025 -- Women experience a great deal of pain or discomfort from common gynecological problems like endometriosis, heavy or irregular periods and ovarian cysts.But even worse, these reproductive health problems might be increasing.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Scientists design battery that runs on atomic waste

Science Daily: Pharmacology News

Researchers have developed a battery that can convert nuclear energy into electricity via light emission, a study suggests.

Research 242
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Just One Hour of Screen Time Increases Risk of Nearsightedness

Drugs.com

TUESDAY, Feb. 25, 2025 -- Each hour a person spends squinting into a smartphone or staring at a screen increases their risk of nearsightedness, a new evidence review suggests.Every daily one-hour increment in digital screen time is associated with.

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The galactic journey of our solar system

Science Daily: Pharmacology News

Astronomers have discovered that the Solar System traversed the Orion star-forming complex, a component of the Radcliffe Wave galactic structure, approximately 14 million years ago. This journey through a dense region of space could have compressed the heliosphere, the protective bubble surrounding our solar system, and increased the influx of interstellar dust, potentially influencing Earth's climate and leaving traces in geological records.

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Cover Image

Chemical Biology and Drug Design

Cover Image molekuul_be/Shutterstock.

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From scraps to sips: Everyday biomass produces drinking water from thin air

Science Daily: Pharmacology News

Discarded food scraps, stray branches, seashells and many other natural materials are key ingredients in a system that can pull drinkable water out of thin air developed by researchers.

Research 207
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The Molecular Mechanism of Resveratrol in the Treatment of Chronic Rhinosinusitis Through a Combination of Network Pharmacology and In Vitro Validation

Chemical Biology and Drug Design

A combination of network pharmacology and invitro validation was used to reveal the potential targets and molecular mechanisms of resveratrol for CRS treatment. ABSTRACT Resveratrol (RES) is a polyphenolic antioxidant derived from different plant products, which has anti-inflammatory and antioxidative stress effect. However, the effect of resveratrol on chronic rhinosinusitis (CRS) still lacks systematic research.

Treatment 100
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Lunar Trailblazer blasts off to map water on the moon

Science Daily: Pharmacology News

On Wednesday 26 February, a thermal imaging camera blasted off to the Moon as part of NASA's Lunar Trailblazer mission. This aims to map sources of water on the Moon to shed light on the lunar water cycle and to guide future robotic and human missions.

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Accelerate the Replication of Oracle Fusion Cloud Apps Data into Databricks

Perficient: Drug Development

Following up on my previous post which highlights different approaches of accessing Oracle Fusion Cloud Apps Data from Databricks, I present in this post details of Approach D, which leverages the Perficient accelerator solution. And this accelerator applies to all Oracle Fusion Cloud applications: ERP, SCM, HCM and CX. As demonstrated in the previous post , the Perficient accelerator differs from the other approaches in that it has minimal requirements for additional cloud platform services.

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