Science Daily: Pharmacology News

APRIL 26, 2024

Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. However, the risk of arrhythmias following this procedure is reportedly high. In a recent study, researchers tested a novel approach that involves injecting 'cardiac spheroids,' cultured from human stem cells, directly into damaged ventricles.

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BioPharma Drive: Drug Pricing

APRIL 26, 2024

The Food and Drug Administration approval of Beqvez comes as other gene therapies for the bleeding condition that were approved earlier struggle to gain traction.

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Therapies Drugs 302

Science Daily: Pharmacology News

APRIL 26, 2024

Are mice clever enough to be strategic? A neuroscientist who studies learning in humans and animals, and who has long worked with mice, wondered why rodents often performed poorly in tests when they knew how to perform well. With a simple experiment, and by acting as 'a little bit of a mouse psychologist,' he and his team figured it out.

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Drugs.com

APRIL 26, 2024

FRIDAY, April 25, 2024 -- Warning letters sent by Medicare officials can prompt a decline in antipsychotic prescriptions for seniors with dementia, a new study finds.Letters sent to heavy prescribers of quetiapine (Seroquel), the most popular.

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Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Science Daily: Pharmacology News

APRIL 26, 2024

Researchers have developed a new PCB that performs on par with traditional materials and can be recycled repeatedly with negligible material loss. Researchers used a solvent that transforms a type of vitrimer -- a cutting-edge class of polymer -- into a jelly-like substance without damage, allowing solid components to be plucked out for reuse or recycling.

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Research 297

Science Daily: Pharmacology News

APRIL 26, 2024

Using environmental DNA analysis, an international team of researchers identified a collection of plants used in ceremonial rituals in the ancient Maya city of Yaxnohcah in Mexico. The plants, known for their religious associations and medicinal properties, were discovered beneath a plaza floor where a ballcourt was built.

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Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 (HealthDay) -- Between 2018 and the spring of 2023, a cluster of clients who had gotten 'vampire facial' microneedling skin treatments at a New Mexico spa were diagnosed with HIV, probably via poorly cleaned instruments, a new.

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Science Daily: Pharmacology News

APRIL 26, 2024

Researchers co-led a study that will improve the detection of gravitational waves--ripples in space and time.

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Research 275

Collaborative Drug

APRIL 26, 2024

New Interface for Protocol Readout Definitions We are excited to announce a new, modern GUI for creating Protocol readout definitions in CDD Vault. This update provides a more intuitive and flexible approach to managing your data, especially for handling dose-response calculations essential for the upcoming Curve Analytics module. Key Features: Modular Approach to Readout Definitions: Dose-Response:: Users must define their concentration and raw data values independently.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- The emotional turmoil caused by a stolen dog is akin to that of a parent losing a child, a new study finds.The findings support the idea that pets truly become family members to their owners, researchers said. When faced.

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Research 246

BioPharma Drive: Drug Pricing

APRIL 26, 2024

Prescription volume erosion is tracking with company forecasts, executives claimed, even as more insurers could exclude the branded drug.

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Biosimilars Drugs 180

Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- Bits of bird flu virus have been discovered in roughly 20% of retail milk samples tested in a national survey, the U.S. Food and Drug Administration said Thursday.The finding suggests that bird flu has spread far more.

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LifeSciVC

APRIL 26, 2024

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest quarterly pace in eight years during 1Q 2024. With just over 60 new biotechs raising their first round of financing, the sector’s company formation activity has slowed 50-60% from its historic peak in 2021.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- Most seniors probably view any emergency surgery with a certain level of anxiety. Now, a new study seeks to sort out who might be at highest risk for a complication from such surgeries -- and which surgeries are more.

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ASPET

APRIL 26, 2024

Recent studies suggest that amongst the GABA A receptor subtype heterogeneity, α2/α3 subunits of GABA A receptors mediate pain processing. Therefore, α2/α3-subtype selective GABA A receptor positive allosteric modulators (PAMs) may be candidate analgesics. Antinociceptive effects of α2/α3-subtype selective GABA A receptor PAMs have been reported, but the behavioral effects of these compounds have not been systematically evaluated.

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Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- Better heart health can lead to a sharper mind for middle-aged Black women, a new study says.

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ASPET

APRIL 26, 2024

Dotinurad was developed as a uricosuric agent, inhibiting urate (UA) reabsorption through the UA transporter URAT1 in the kidneys. Due to its high selectivity for URAT1 among renal UA transporters, we investigated the mechanism underlying this selectivity by identifying dotinurad binding sites specific to URAT1. Dotinurad was docked to URAT1 using AutoDock4, utilizing the AlphaFold2-predicted structure.

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Drugs 100

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- The U.S. Department of Agriculture is clamping down on salmonella bacteria found in breaded, stuffed raw chicken products, with the agency issuing a final rule on the issue Friday.The agency's Food Safety and Inspection.

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Production 245

ASPET

APRIL 26, 2024

Histone deacetylase expression and activity are often dysregulated in central nervous system (CNS) tumors, providing a rationale for investigating histone deacetylase inhibitors (HDACIs) in selected brain tumor patients. Although many HDACIs have shown potential in in vitro studies, they have had modest efficacy in vivo. This lack of activity could be due to insufficient CNS exposure to the unbound drug.

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Pharmacogenetics Pharmacokinetics Clinical Trials Trials 100

Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- Advanced scanning techniques can find hidden inflammation in the brains of multiple sclerosis (MS) patients, a new study shows.This “smoldering” inflammation detected by positron emission tomography (PET) brain scans.

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Drug Channels

APRIL 26, 2024

Today’s guest post comes from Kevin Kettler, President of CoverMyMeds. Kevin asks: What if there were no barriers across the therapy access and reimbursement process? In his view, eliminating barriers requires a combination of expert insight, actionable data, and simplification of the providers' experiences. Click here to learn more about CoverMyMeds’ comprehensive technology solutions.

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Therapies Drugs 96

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Cytel

APRIL 26, 2024

Written by Marie Diamond and Maria Rizzo Systematic literature reviews (SLR) are essential to informing healthcare decision-making and are pivotal for reimbursement submissions to health technology assessment (HTA) bodies. One limitation of SLRs, however, is that they quickly become outdated due to the continuous publication of new literature. The living systematic review (LSR) model can overcome this challenge by incorporating relevant new evidence as it is published.

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Clinical Development 64

Drug Patent Watch

APRIL 26, 2024

This chart shows the drugs with the most patents in South Africa.

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Agency IQ

APRIL 26, 2024

BY WALKER LIVINGSTON, ESQ The EPA has finalized a rule to designate PFOA and PFOS – two prevalent PFAS chemicals – as hazardous substances under the federal Superfund law. The designation will kickstart a wide array of actions across the U.S., including cleanups, remediation and litigation. Although a companion enforcement policy intends to exempt certain entities as responsible parties, questions on liability remain.

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Drug Patent Watch

APRIL 26, 2024

Annual Drug Patent Expirations for OXYCONTIN Oxycontin is a drug marketed by Purdue Pharma Lp and is included in one NDA. It is available from three suppliers.

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Agency IQ

APRIL 26, 2024

BY LAURA DIANGELO, MPH A final rule requiring Laboratory Developed Tests (LDTs) to be regulated as medical devices has obtained clearance from the White House’s Office of Information and Regulatory Affairs today, allowing the FDA to publish the regulation as early as this week. Simultaneously, OIRA also cleared two additional guidance documents that seek to define how diagnostics are used in public health emergencies, which are likely intended to answer key questions raised by the LDT final rule

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Drug Patent Watch

APRIL 26, 2024

Annual Drug Patent Expirations for XOSPATA Xospata is a drug marketed by Astellas and is included in one NDA. It is available from one supplier.

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Drugs Marketing 59

Agency IQ

APRIL 26, 2024

BY RAYAN BHARGAVA, MSC , KARI OAKES The European Food Safety Authority’s (EFSA’s) substantial lowering of the limit of bisphenol A considered safe in humans was recently lauded by a group of scientists and clinicians. In an article, the group applauds a regulatory toxicology approach that considers academic as well as guideline-directed studies, though EFSA’s findings have engendered some regulatory dissonance between the EU and various national agencies on appropriate limits for the endocrine-d

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Drug Patent Watch

APRIL 26, 2024

Annual Drug Patent Expirations for SLYND Slynd is a drug marketed by Exeltis Usa Inc and is included in one NDA. It is available from one supplier.

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