Fri.May 16, 2025

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Ancient ocean sediments link changes in currents to cooling of Northern Hemisphere 3.6 million years ago

Science Daily: Pharmacology News

New research from an international group looking at ancient sediment cores in the North Atlantic has for the first time shown a strong correlation between sediment changes and a marked period of global cooling that occurred in the Northern Hemisphere some 3.6 million years ago. The changes in sediments imply profound changes in the circulation of deep water currents occurred at this time.

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Novo CEO to depart as obesity drugmaker’s challenges rise

BioPharma Drive: Drug Pricing

Lars Fruergaard Jørgensen will step down after eight years helming the Danish drugmaker, shares of which have lost more than half their value over the past 12 months.

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Rising temperatures lead to unexpectedly rapid carbon release from soils

Science Daily: Pharmacology News

How sensitively does organic carbon stored in soils react to changes in temperature and humidity?

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Regeneron defeats Amgen in PCSK9 case; 2 cell therapy biotechs cut staff

BioPharma Drive: Drug Pricing

A federal jury found Amgen liable for violating antitrust and tort laws. Elsewhere, Allogene and Kyverna trimmed staff and the FDA scheduled an advisory meeting.

Therapies 152
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Resetting the Walk-Away Price: How GoodRx Data Reveals New Realities of Prescription Abandonment

Drug Channels

Todays guest post is from Divya Iyer, SVP of Go-to-Market Strategy at GoodRx. Divya shares new GoodRx data showing that out-of-pocket costs at the pharmacy counter remain a primary barrier to medication adherence. Despite the availability of manufacturer-sponsored support programs, many patients still abandon their prescriptions due to high costs. To learn about GoodRxs prescription abandonment solutions, download Reduce Rx Abandonment at the Pharmacy.

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BioMarin to buy rare disease drugmaker Inozyme for $270M

BioPharma Drive: Drug Pricing

The deal “fits like a glove” for BioMarin’s business, according to an analyst who also thinks there could be a “valuable” market opportunity for Inozyme’s main drug.

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Xiao Wang - Core Institute Member

Broad Institute

Xiao Wang - Core Institute Member By Rose Circeo May 16, 2025 Breadcrumb Home Xiao Wang - Core Institute Member Xiao Wang, a core institute member at the Broad Institute, describes her lab's work developing tools to understand how the brain works across multiple spatial scales. Wang reflects on the importance of interdisciplinary research, her teaching philosophy, and the culture she aims to cultivate in her lab.

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Consultant’s Corner—Reflections from a Study Monitor and Director: A Career in Toxicology, by Bill Brock

Alta Sciences

Consultants CornerReflections from a Study Monitor and Director: A Career in Toxicology, by Bill Brock pmjackson Fri, 05/16/2025 - 18:40 Some might say a reflective piece like this could come across as sounding preachy. Maybe it is. But it is reflective of a long and rewarding career built on the belief that we as scientists need to give back to the field of toxicology, supporting the growth of future leaders.

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Wild orangutans show communication complexity thought to be uniquely human

Science Daily: Pharmacology News

Researchers have found that wild orangutans vocalize with a layered complexity previously thought to be unique to human communication, suggesting a much older evolutionary origin.

Research 286
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Toxic Metals Found in All Rice Samples in New Study

Drugs.com

FRIDAY, May 16, 2025 A new report says rice sold in U.S. stores contains toxic heavy metals, including arsenic, cadmium, lead and mercury.The report released by Healthy Babies, Bright Futures found arsenic in 100% of rice samples tested from s.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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New auditory brainstem implant shows early promise

Science Daily: Pharmacology News

Investigators are developing a new type of auditory brainstem implant that is designed to be soft, and flexible and address limitations of models currently in use. These implants may one day benefit people who can't receive a cochlear implant, such as those with Neurofibromatosis type 2 (NF2) and other severe inner ear abnormalities. In a new preclinical study, researchers report on benefits in large animal models, and based on the results, hope for future trials in humans.

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Republican Medicaid Cuts Could Cause Rural Hospital Closures, CEOs Warn HealthDay TV

Drugs.com

FRIDAY, May 16, 2025 Proposed cuts to Medicaid could be devastating to Americas rural hospitals, health care CEOs are warning in interviews with HealthDay.House Republicans have proposed an $880 billion reduction in Medicaid funding. Combined wit.

Hospitals 253
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Very different mammals follow the same rules of behavior

Science Daily: Pharmacology News

In the natural world -- where predators pounce, prey flee, and group members feed and sleep in solidarity -- animal behavior is glorious in its variety. Now, new research suggests there may be an underlying architecture that orders the movements of animals as they go about their very different lives. And it's more widespread than previously imagined.

Research 215
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Houston Wastewater Foretold Texas Measles Outbreak

Drugs.com

FRIDAY, May 16, 2025 Measles virus popped up in Houston wastewater weeks before a notorious Texas outbreak of the highly infectious disease started in January, a new study says.Wastewater samples collected Jan. 7 contained genetic evidence of m.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Researchers find CRISPR is capable of even more than we thought

Science Daily: Pharmacology News

Newly discovered weapons of bacterial self-defense take different approaches to achieving the same goal: preventing a virus from spreading through the bacterial population.

Virus 212
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Novo Nordisk, U.S. Biotech Company Team Up to Create Obesity Pills

Drugs.com

FRIDAY, May 16, 2025 Danish drugmaker Novo Nordisk is teaming up with California-based biotech Septerna to develop new pills to treat obesity, type 2 diabetes and other metabolic diseases.The deal could be worth up to $2.2 billion for Septerna. T.

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Study reveals healing the ozone hole helps the Southern Ocean take up carbon

Science Daily: Pharmacology News

New research suggests that the negative effects of the ozone hole on the carbon uptake of the Southern Ocean are reversible, but only if greenhouse gas emissions rapidly decrease. The study finds that as the ozone hole heals, its influence on the ocean carbon sink of the Southern Ocean will diminish, while the influence of greenhouse gas (GHG) emissions will rise.

Research 205
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Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

Covalent Modifiers

A.E. Maciag,Y. Yang,A.K. Sharma,D.M. Turner,C.J. DeHart,H. Abdelkarim,L. Fan,B.P. Smith,V. Kumari,M. Dyba,M. Rigby,J.A. Castillo Badillo,L. Adams,L. Fornelli,S. Fox,A. Brafman,T. Turbyville,W. Gillette,S. Messing,[.]& F. McCormick, Proc. Natl. Acad. Sci. 2025 122 (19) e2410766122, [link] RAS is the most frequently mutated oncogene in cancer. RAS proteins show high sequence similarities in their G-domains but are significantly different in their C-terminal hypervariable regions (HVR).

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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In healthy aging, carb quality counts

Science Daily: Pharmacology News

Intakes of dietary fiber and high-quality carbohydrates in midlife are linked to increased likelihood of healthy aging and other positive health outcomes in older women. Higher intakes of refined carbohydrates and starchy vegetables were associated with lower odds of healthy aging.

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Testosterone Therapy Doesn't Increase Cancer Risk For Transmasculine People

Drugs.com

FRIDAY, May 16, 2025 Transmasculine and gender diverse people who use testosterone are not at an increased risk for cervical, ovarian or other gynecological cancers, a new study says.The results show that hormone therapy can safely be used to i.

Therapies 147
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One in ten asthma cases can be avoided with a better urban environment

Science Daily: Pharmacology News

The combination of air pollution, dense urban development and limited green spaces increases the risk of asthma in both children and adults.

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FDA Gives Marketing Nod to Blood Test for Diagnosing Alzheimer Disease

Drugs.com

FRIDAY, May 16, 2025 -- The first in vitro diagnostic device that uses blood samples to detect Alzheimer disease has been granted marketing clearance by the U.S. Food and Drug Administration.The Lumipulse G pTau217/-Amyloid 1-42 Plasma Ratio is.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Log in to your computer with a secret message encoded in a molecule

Science Daily: Pharmacology News

Molecules like DNA are capable of storing large amounts of data without requiring an energy source, but accessing this molecular data is expensive and time consuming. Researchers have now developed an alternative method to encode information in synthetic molecules, which they used to encode and then decode an 11-character password to unlock a computer.

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Barbie's Feet Have Changed With The Times

Drugs.com

FRIDAY, May 16, 2025 Barbies arched feet became something of a statement on female empowerment in her 2023 movie.Her feet initially remained arched even when she stepped out of high heels, but to Barbie's horror fell flat as she started to think.

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Overlooked cell type orchestrates brain rewiring

Science Daily: Pharmacology News

Researchers have shown in mice that brain cells known as astrocytes are required for a signaling chemical called norepinephrine to modify brain activity, changing the textbook understanding that norepinephrine acts directly on neurons.

Research 158
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Demannose

New Drug Approvals

Demannose CAS 530-26-7, 3458-28-4 180.16 g/mol D-Mannopyranose Carubinose Seminose mannopyranose (3 S ,4 S ,5 S ,6 R )-6-(hydroxymethyl)oxane-2,3,4,5-tetrol C 6 H 12 O 6 D-mannopyranose congenital glycosylation disorders D-mannopyranose is d-Mannose in its six-membered ring form. It has a role as a metabolite. It is a D-aldohexose, a D-mannose and a mannopyranose.

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Jill Boisvert Fosters Continuous Learning in Perficient’s Salesforce Practice

Perficient: Drug Development

From Operations to Project Management: How Jill Boisvert Drives Success in Perficients Salesforce BU Perficient promote s meaningful growth by challenging, championing, and celebrating every colleague. We recently connected with Jill Boisvert , project manager , whose passion for knowledge sharing has ignited genuine connections with in Perficients Salesforce Business Unit (BU).

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An Introduction To Biostatistics In Clinical Trials

Quanticate

Biostatistics is a specialised field of statistics focused on analysing biological and medical data. In clinical trials, it plays a pivotal role in the design, execution, and reporting of research. By providing scientific tools and methodologies, biostatistics ensures that study findings are robust, valid, and applicable to real-world healthcare scenarios.

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Apps in Generative AI – Transforming the Digital Experience

Perficient: Drug Development

Generative AI (GenAI) is not just a buzzword anymore it’s rapidly transforming the way we interact with technology. From content creation to design automation and synthetic media, GenAI apps are redefining productivity and creativity across industries. But what exactly are GenAI apps, and how are they impacting our digital landscape? What Are GenAI Apps?

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Medicare Low-Income Drug Benefit Saves Lives, Study Says

Drugs.com

FRIDAY, May 16, 2025 Low-income Medicare beneficiaries are more likely to die if they lose access to crucial medication coverage, a new study says.More than 14 million poor Medicare beneficiaries receive the Medicare Part D Low-Income Subsidy (.

Drugs 227
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Deupsilocin

New Drug Approvals

Deupsilocin, Psilocin-d10 Psilocin-D10 Deupsilocin Psilocine-d10 Molecular Formula C12H16N2O Molecular Weight 214.3299 KXD3HS8D6X CAS 1435934-64-7 3-[2-[Di(methyl- d 3 )amino]ethyl- 1 , 1 , 2 , 2 – d 4 ]-1 H -indol-4-ol 3-[2-[bis(trideuteriomethyl)amino]-1,1,2,2-tetradeuterioethyl]-1 H -indol-4-ol 1H-Indol-4-ol, 3-[2-[di(methyl-d3)amino]ethyl-1,1,2,2-d4]- Mental health disorders, or mental illness, refer to a wide range of disorders that include, but are not limited to, depressive disorder

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Custom Gene Editing Helps Baby With Rare Condition

Drugs.com

FRIDAY, May 16, 2025 A baby born with a rare and deadly genetic disease is the world's first known patient to receive an experimental gene editing treatment designed just for him.KJ Muldoon from Clifton Heights, Pa., is thriving after the therapy.

Therapies 152