Drugs.com

APRIL 26, 2025

SATURDAY, April 26, 2025 From beetles to moths, leafhoppers and butterflies, the world's insects are vanishing at a breakneck pace.Since 2017, when European researchers reported that insect populations had declined 75% in fewer than 30 years, s.

Research 166

Research 166

Practical Cheminformatics

APRIL 26, 2025

After more than eight years on Blogger, I've decided to move Practical Cheminformatics to a new location. Formatting posts on Blogger has always been a struggle, and I'd prefer to be able to write posts in markdown. This site will remain as an archive for previous posts, but all new content will be posted under the "Blog" link on my website [link].

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Covalent Modifiers

APRIL 26, 2025

Lauren M Orr, Sydney J Tomlinson, Hannah R Grupe, Melissa Lim, Emily Ho, Halime Yilmaz, Grace Zhou, Barbara Leon, James A Olzmann, Daniel K Nomura bioRxiv 2025.04.25.650514; doi: [link] Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, the rational design of monovalent or molecular glue degraders remains challenging.

Targeted Protein Degradation 162

Targeted Protein Degradation DNA Disease 162

New Drug Approvals

APRIL 26, 2025

BOFUTRELVIR Cas 2103278-86-8 Molecular Weight 452.55 Formula C 25 H 32 N 4 O 4 UNII-T5UX5SKK2S; Mpro inhibitor 11A; 2103278-86-8; T5UX5SKK2S, DC-402234, DC402234, MPI-10 IUPAC/Chemical Name: N-[(2S)-3-cyclohexyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1H-indole-2-carboxamide N -[(2 S )-3-cyclohexyl-1-oxo-1-[[(2 S )-1-oxo-3-[(3 S )-2-oxopyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1 H -indole-2-carboxamide Bofutrelvir has an additive antiviral effect whe

Small Molecule 57

Small Molecule RNA Clinical Trials Trials 57

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials