Science Daily: Pharmacology News
FEBRUARY 10, 2025
Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs. This is likely down to new breeding practices introduced at the beginning of the 20th century. The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries.
Covalent Modifiers
FEBRUARY 10, 2025
DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the 14-3-3 protein family, which interacts with several hundred client proteins and plays a central role in cellular net
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BioPharma Drive: Drug Pricing
FEBRUARY 24, 2025
Cavazzoni stepped down from her role as head of the FDA’s main drug review office in mid-January. She will succeed Aida Habtezion.
Codon
FEBRUARY 13, 2025
One of the ultimate aims of protein design has long been to build entirely new enzymes — proteins that perform specific chemical reactions — from scratch. These molecular machines power various cellular processes, from converting sugar into energy to switching genes on and off. Both Cas9 and hydrolases (widely used in the dairy and laundry industries) are also enzymes.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Drugs.com
FEBRUARY 10, 2025
MONDAY, Feb. 10, 2025 -- Yes, rare cases of vision issues have arisen in people taking popular GLP-1 weight loss drugs, but the jury's out on whether the medications caused the eye trouble, according to a new small study.The study reviewed the.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
FEBRUARY 21, 2025
Researchers have applied a visualization technique to depict the brain's activity related to visual perception as geometric patterns. They visualized different shapes as the ever-changing neuronal activity in the temporal and frontal lobes of the brain during object recognition and recalling memories. This achievement promises further extraction of brain activity observed in various aspects of daily life.
Covalent Modifiers
FEBRUARY 21, 2025
Teresa Marker, Raphael R. Steimbach, Cecilia Perez-Borrajero, Marcin Luzarowski, Eric Hartmann, Sibylle Schleich, Daniel Pastor-Flores, Elisa Espinet, Andreas Trumpp, Aurelio A. Teleman, Frauke Grter, Bernd Simon, Aubry K. Miller & Tobias P. Dick Nat. Chem. ( 2025 ). [link] Proton pump inhibitors have become top-selling drugs worldwide. Serendipitously discovered as prodrugs that are activated by protonation in acidic environments, proton pump inhibitors inhibit stomach acid secretion by cov
BioPharma Drive: Drug Pricing
FEBRUARY 25, 2025
Ten of 11 children born with a rare form of congenital hearing loss experienced improvements after receiving the company’s treatment, new data show.
Chemical Biology and Drug Design
FEBRUARY 6, 2025
Analysis of prevalence of ring, nonring, sp 3 -, and sp 2 -hybridized oxygen in approved drugs. For the first time, analysis of distribution of different types of oxygen from center of mass of a molecule. ABSTRACT Despite advancements in molecular design rules and understanding biochemical processes, the field of drug design and discovery seeks to minimize the number and duration of synthesis-testing cycles to convert lead compounds into drug candidates.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drugs.com
FEBRUARY 27, 2025
THURSDAY, Feb. 27, 2025 -- With egg prices soaring due to a severe bird flu outbreak, the U.S. Department of Agriculture (USDA) announced a $1 billion plan to contain the disease and help poultry farmers recover. The outbreak has destroyed flocks.
addgene Blog
FEBRUARY 13, 2025
Early CRISPR applications were often limited by the low editing efficiency of homology-directed repair (HDR) , the pathway for resolving DNA double-strand breaks (DSBs) preferred by researchers. Compared to non-homologous end joining (NHEJ) , HDR occurs at a relatively low frequency, especially in nondividing cells. Scientists everywhere wistfully imagined being able to specify and correct single-base mutations without introducing DSBs at all.
Science Daily: Pharmacology News
FEBRUARY 17, 2025
Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier. The findings demonstrate the potential of this technology to pave the way for future treatments for a wide range of conditions such as Alzheimer's disease, amyotrophic lateral sclerosis, brain cancer, and drug addiction.
Covalent Modifiers
FEBRUARY 25, 2025
James Cregg, Kristof Pota, Aidan C. A. Tomlinson, Jason Yano, Abby Marquez, Yang Liu, Christopher J. Schulze, Kyle J. Seamon, Matthew Holderfield, Xing Wei, Yongxian Zhuang, Yu Chi Yang, Jingjing Jiang, Yue Huang, Ruiping Zhao, Yun Ling, Zhican Wang, Michael Flagella, Zhengping Wang, Mallika Singh, John E. Knox, Robert Nichols, David Wildes, Jacqueline A.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
FEBRUARY 4, 2025
Louisiana Sen. Bill Cassidy joined his Republican colleagues in voting to advance Kennedy's nomination to a vote by the full Senate.
Chemical Biology and Drug Design
FEBRUARY 3, 2025
An in-house molecule library was screened using in silico molecular docking, and a myo-inositol derivative was identified as a potent hit molecule. The invitro biochemical assays validated that J1-65 inhibits PTP-PEST activity competitively and the inhibitor binding stabilizes the protein-ligand complex. ABSTRACT PTP-PEST (also known as PTPN12) regulates cellular signaling and transduction pathways by dephosphorylating its substrate.
Drugs.com
FEBRUARY 24, 2025
MONDAY, Feb. 24, 2025 -- People taking the weight-loss drug semaglutide could be at a slightly increased risk for a potentially blinding eye condition that affects the optic nerve, a new study says.Patients on semaglutide (Ozempic, Wegovy) had a.
Collaborative Drug
FEBRUARY 26, 2025
Analysis of Total Cost of Ownership across leading biotech R&D software lab data management platforms including CDD Vault, Benchling and Dotmatics.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
FEBRUARY 12, 2025
Climate scientists present a realistic supercomputer simulation that resolves the complex interactions between fire, vegetation, smoke and the atmosphere. The authors find that increasing greenhouse gas emissions will likely increase the global lightning frequency by about 1.6% per degree Celsius global warming, with regional hotspots in the eastern United States, Kenya, Uganda and Argentina.
Covalent Modifiers
FEBRUARY 6, 2025
Merve Demir,*, Laura Koepping, Ya Li, Lynn Fujimoto, Andrey Bobkov, Jianhua Zhao, Taro Hitosugi, Eduard Sergienko Structure, 2024 [link] Mitochondrial creatine kinases (MtCKs) are key players in maintaining energy homeostasis in cells that work with cytosolic creatine kinases for energy transport from mitochondria to cytoplasm. The inhibition of breast cancer growth by cyclocreatine targeting CKs indicates dependence of cancer cells on the energy shuttle for cell growth and survival.
BioPharma Drive: Drug Pricing
FEBRUARY 25, 2025
Telehealth provider Hims & Hers said it will tell consumers they need to seek “alternative options on the commercial dosing,” but in earnings Monday still forecast higher revenue and profits in 2025.
Science Daily: Pharmacology News
FEBRUARY 25, 2025
New research has revealed how massive ancient glaciers acted like giant bulldozers, reshaping Earth's surface and paving the way for complex life to flourish. By chemically analyzing crystals in ancient rocks, the researchers discovered that as glaciers carved through the landscape, they scraped deep into the Earth's crust, releasing key minerals that altered ocean chemistry.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
FEBRUARY 25, 2025
Making enemies isn't random. Traits like emotional instability, aggression, and disruptive behavior early in life can lead to antagonistic relationships. Research on students aged 9-14 found that negative behaviors, such as lack of empathy, increase the likelihood of mutual antagonisms, a pattern seen across genders and school levels. Emotionally struggling students were 35% more likely to develop enemies, showing that how we manage emotions and interact with others early on can have lasting soc
Science Daily: Pharmacology News
FEBRUARY 20, 2025
Researchers have found that stars in the early universe may have formed from 'fluffy' molecular clouds. Using the ALMA telescope to observe the Small Magellanic Cloud -- whose environment is similar to the early universe -- they observed that about 60% of the observed clouds had the common filamentary structure, while the remaining 40% had a 'fluffy' shape.
Science Daily: Pharmacology News
FEBRUARY 4, 2025
New assessment warns area the size of the USA will become too hot during extreme heat events for even healthy young humans to maintain a safe body temperature if we hit 2 degrees Celsuis above preindustrial levels. For those aged over 60, the same 2 degree rise would see more than a third of the planet's land mass cross this critical 'overheating' threshold.
Covalent Modifiers
FEBRUARY 13, 2025
Hui Tao, Bo Yang, Atena Farhangian, Ke Xu, Tongtong Li, Zhong-Yin Zhang, and Jianing Li Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02760 Covalent-allosteric inhibitors (CAIs) may achieve the best of both worlds: increased potency, long-lasting effects, and reduced drug resistance typical of covalent ligands, along with enhanced specificity and decreased toxicity inherent in allosteric modulators.
Science Daily: Pharmacology News
FEBRUARY 20, 2025
Large birds -- our closest relations to dinosaurs -- are capable of technical innovation, by solving a physical task to gain access to food.
Science Daily: Pharmacology News
FEBRUARY 13, 2025
Who hasn't been there? The big meal is over, you're full, but the craving for sweets remains. Researchers have now discovered that what we call the 'dessert stomach' is rooted in the brain. The same nerve cells that make us feel full after a meal are also responsible for our craving for sweets afterwards.
Science Daily: Pharmacology News
FEBRUARY 6, 2025
Researchers have unveiled the precise brain mechanisms that enable animals to overcome instinctive fears. The study in mice could have implications for developing therapeutics for fear-related disorders such as phobias, anxiety and post-traumatic stress disorder (PTSD).
Science Daily: Pharmacology News
FEBRUARY 21, 2025
Researchers are blurring the lines between robotics and materials, with a proof-of-concept material-like collective of robots with behaviors inspired by biology.
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