November, 2024

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Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report. Dubbed the NanoGripper, the nanorobotic hand also could be programmed to interact with other viruses or to recognize cell surface markers for targeted drug delivery, such as for cancer treatment.

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Scalable Thiol Reactivity Profiling Identifies Azetidinyl Oxadiazoles as Cysteine-Targeting Electrophiles

Covalent Modifiers

Fereshte Ghorbani, Shaochen You, Gennadii A. Grabovyi, Mannkyu Hong, Garrett Lindsey, Arnab K. Chatterjee, and Michael J. Bollong Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c05711 Cysteine reactive groups are a mainstay in the design of covalent drugs and probe molecules, yet only a handful of electrophiles are routinely used to target this amino acid.

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An RNAi renaissance is creating a new generation of startups

BioPharma Drive: Drug Pricing

Pioneers like Alnylam Pharmaceuticals have led the RNA interference field for years. Now, a crop of young biotechs is building on that foundation by taking the drugmaking technology in new directions.

RNA 347
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Diabetes Meds Metformin, GLP-1s Can Also Curb Asthma

Drugs.com

MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.

Research 325
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Recent changes to ELN

Collaborative Drug

Updates to ELN annotation tool, ELN insert link hotkey, auto generated sample IDs, list searching in inventory, flag outliers during imports

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Towards a hydrogen-powered future: Highly sensitive hydrogen detection system

Science Daily: Pharmacology News

Hydrogen, a promising fuel, has extensive applications in many sectors. However, its safe and widespread use necessitates reliable sensing methods. While tunable diode laser absorption spectroscopy (TDLAS) has proved to be an effective gas sensing method, detecting hydrogen using TDLAS is difficult due to its weak light absorption property in the infrared region.

Research 298
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Covalency in PROTACs: Mechanisms and applications [@RPNowak]

Covalent Modifiers

Thomas M. Geiger, Radosław P. Nowak Annual Reports in Medicinal Chemistry , 2024 [link] Proteolysis targeting chimeras (PROTACs) are hetero-bifunctional molecules that remove disease-causing proteins through the means of targeted protein degradation (TPD). Since their proof-of-concept over 20 years ago, PROTACs emerged as new modality in drug discovery and chemical biology.

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FDA endorses speedy approval path for Regenxbio Duchenne gene therapy

BioPharma Drive: Drug Pricing

The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.

Therapies 332
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U.S. Postpartum Depression Diagnoses Doubled in a Decade

Drugs.com

WEDNESDAY, Nov. 20, 2024 -- Rates of postpartum depression have more than doubled in little over a decade among American women, a new analysis shows. While about 1 in every 10 new moms (9.4%) suffered postpartum depression in 2010, that number rose.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Quantum Computing and Cybersecurity: Preparing for a Quantum-Safe Future

Perficient: Drug Development

Quantum computing is rapidly transitioning from theory to reality, using the principles of quantum mechanics to achieve computational power far beyond traditional computers. Imagine upgrading from a bicycle to a spaceship—quantum computers can solve complex problems at extraordinary speeds. However, this leap in computing power poses significant challenges, particularly for cybersecurity, which forms the backbone of data protection in our digital world.

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Breakthrough in capturing 'hot' CO2 from industrial exhaust

Science Daily: Pharmacology News

Capturing carbon dioxide from the hot industrial exhaust of cement and steel plants requires cooling the exhaust from around 200 C to 60 C so that liquid amines can react with the CO2. Chemists have now created a new type of metal-organic framework that captures CO2 at high temperatures, avoiding the need to expend energy and water to cool the exhaust.

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Superior photosynthesis abilities of some plants could hold key to climate-resilient crops

Science Daily: Pharmacology News

Scientists discovered a stretch of DNA in both C3 plants, like wheat and soybeans, and C4 plants, like corn and sorghum, that is responsible for optimizing C4 plant photosynthesis and making them better at withstanding heat and drought. The findings are insightful in understanding how some plants evolved to be more efficient, and may now be used as a springboard for turning C4 photosynthesis on in C3 plants -- an important step for creating sustainable crop populations in the face of climate cha

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Total Synthesis of Tagitinins, Goyazensolide and RelatedFuranoheliangolides and their Covalent Interaction withImportin-5 (IPO5)

Covalent Modifiers

W Liu, R Patouret, E Peev, S Barluenga, N Winssinger Helvetica Chimica Acta , 2024 [link] Herein, we detail an extension of our research on the synthesis of a small library of furanoheliangolides and the characterization of the covalent interaction between goyazensolide and IPO5. Using a build‐couple‐pair strategy, we assembled a small library of germacrene‐type lactones and diversified them into eight groups of structurally different analogues.

Research 162
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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NASA satellites reveal abrupt drop in global freshwater levels

Science Daily: Pharmacology News

The Earth's total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. The shift could indicate Earth's continents have entered a persistently drier phase.

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Unexplained heat-wave 'hotspots' are popping up across the globe

Science Daily: Pharmacology News

A striking new phenomenon is emerging: distinct regions are seeing repeated heat waves that are so extreme, they fall far beyond what any model of global warming can predict or explain. A new study provides the first worldwide map of such regions, which show up on every continent except Antarctica like giant, angry skin blotches.

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Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation

Covalent Modifiers

Gregory B. Craven, Hang Chu, Jessica D. Sun, Jordan D. Carelli, Brittany Coyne, Hao Chen, Ying Chen, Xiaolei Ma, Subhamoy Das, Wayne Kong, Adam D. Zajdlik, Kin S. Yang, Solomon H. Reisberg, Peter A. Thompson, J. Russell Lipford & Jack Taunton Nature, 2024 [link] Somatic alterations in the oncogenic kinase AKT1 have been identified in a broad spectrum of solid tumours.

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Oldest known alphabet unearthed in ancient Syrian city

Science Daily: Pharmacology News

Researchers have discovered evidence of the oldest alphabetic writing in human history. The writing was etched onto clay cylinders discovered during a dig at an ancient Syrian city.

Research 339
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Target Ligand Separation and Identification of Isoforsythiaside as a Histone Lysine-Specific Demethylase 1 Covalent Inhibitor Against Breast Cancer Metastasis

Covalent Modifiers

Mengzhen Gu, Xiaoqing Xu, Xiaoping Wang, Yun Wang, Yu Zhao, Xiaoxian Hu, Lu Zhu, Zhenzhong Deng, and Chao Han Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.4c02277 Histone lysine-specific demethylase 1 (LSD1) is hyperactive in breast cancer, which is associated with the metastasis of the tumor. Current irreversible LSD1 inhibitors are all synthesized by covalently binding to the flavin adenine dinucleotide cofactor, which often have side effects due to the high affinity for a var

Treatment 147
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Memories are not only in the brain, new research finds

Science Daily: Pharmacology News

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories. But a team of scientists has discovered that cells from other parts of the body also perform a memory function, opening new pathways for understanding how memory works and creating the potential to enhance learning and to treat memory-related afflictions.

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Giving robots superhuman vision using radio signals

Science Daily: Pharmacology News

Researchers have developed PanoRadar, a new tool to give robots superhuman vision by transforming simple radio waves into detailed, 3D views of the environment.

Research 335
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Ancient hot water on Mars points to habitable past

Science Daily: Pharmacology News

New research has uncovered what may be the oldest direct evidence of ancient hot water activity on Mars, revealing the planet may have been habitable at some point in its past.

Research 330
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Sleepiness during the day may be tied to pre-dementia syndrome

Science Daily: Pharmacology News

Older people who are sleepy during the day or lack enthusiasm for activities due to sleep issues may be more likely to develop a syndrome that can lead to dementia, according to a new study.

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Researchers identify previously unknown compound in drinking water

Science Daily: Pharmacology News

Researchers have reported the discovery of a previously unknown compound in chloraminated drinking water. Inorganic chloramines are commonly used to disinfect drinking water to safeguard public health from diseases like cholera and typhoid fever.

Research 327
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Athletes have significantly better working memory than sedentary people

Science Daily: Pharmacology News

A recently published meta-analysis reveals an advantage in sports-related information processing compared to non-athletes. The data consisted of 21 studies involving a total of 1455 participants. Athletes had better working memory than non-athletes and this advantage was further enhanced when athletes were compared to sedentary people.

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Surviving in biotech’s new normal: 5 tips from industry VCs and CEOs

BioPharma Drive: Drug Pricing

At an event hosted by BioPharma Dive, drugmaker executives and investors discussed the importance of focus, smart spending and maintaining lines of sight to the clinic.

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Covalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 Mimetics

Covalent Modifiers

Giulia Alboreggia, Parima Udompholkul, Emma L. Atienza, Kendall Muzzarelli, Zahra Assar, and Maurizio Pellecchia Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.4c01541 Covalent drugs provide pharmacodynamic and pharmacokinetic advantages over reversible agents. However, covalent strategies have been developed mostly to target cysteine (Cys) residues, which are rarely found in binding sites.

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Astrophysicists use echoes of light to illuminate black holes

Science Daily: Pharmacology News

Researchers have developed an innovative technique to search for black hole light echoes. Their novel method, which will make it easier for the mass and the spin of black holes to be measured, represents a major step forward, since it operates independently of many of the other ways in which scientists have probed these parameters in the past.

Research 324
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Can we live on our planet without destroying it?

Science Daily: Pharmacology News

How much land, water, and other resources does our lifestyle require? And how can we adapt this lifestyle to stay within the limits of what the Earth can give? A new article tackles these questions.

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Chimpanzees perform better on challenging computer tasks when they have an audience

Science Daily: Pharmacology News

When people have an audience watching them, it can change their performance for better or worse. Now, researchers have found that chimpanzees' performance on computer tasks is influenced by the number of people watching them. The findings suggest that this 'audience effect' predates the development of reputation-based human societies, the researchers say.

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