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Analysis of prevalence of ring, nonring, sp 3 -, and sp 2 -hybridized oxygen in approved drugs. For the first time, analysis of distribution of different types of oxygen from center of mass of a molecule. ABSTRACT Despite advancements in molecular design rules and understanding biochemical processes, the field of drug design and discovery seeks to minimize the number and duration of synthesis-testing cycles to convert lead compounds into drug candidates.
Merve Demir,*, Laura Koepping, Ya Li, Lynn Fujimoto, Andrey Bobkov, Jianhua Zhao, Taro Hitosugi, Eduard Sergienko Structure, 2024 [link] Mitochondrial creatine kinases (MtCKs) are key players in maintaining energy homeostasis in cells that work with cytosolic creatine kinases for energy transport from mitochondria to cytoplasm. The inhibition of breast cancer growth by cyclocreatine targeting CKs indicates dependence of cancer cells on the energy shuttle for cell growth and survival.
New assessment warns area the size of the USA will become too hot during extreme heat events for even healthy young humans to maintain a safe body temperature if we hit 2 degrees Celsuis above preindustrial levels. For those aged over 60, the same 2 degree rise would see more than a third of the planet's land mass cross this critical 'overheating' threshold.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
WEDNESDAY, Feb. 5, 2025 -- The U.S. Food and Drug Administration has approved Susvimo (ranibizumab) 100 mg/mL for treating diabetic macular edema.Susvimo is the first and only FDA-approved treatment shown to maintain vision in people with diabetic.
An in-house molecule library was screened using in silico molecular docking, and a myo-inositol derivative was identified as a potent hit molecule. The invitro biochemical assays validated that J1-65 inhibits PTP-PEST activity competitively and the inhibitor binding stabilizes the protein-ligand complex. ABSTRACT PTP-PEST (also known as PTPN12) regulates cellular signaling and transduction pathways by dephosphorylating its substrate.
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An in-house molecule library was screened using in silico molecular docking, and a myo-inositol derivative was identified as a potent hit molecule. The invitro biochemical assays validated that J1-65 inhibits PTP-PEST activity competitively and the inhibitor binding stabilizes the protein-ligand complex. ABSTRACT PTP-PEST (also known as PTPN12) regulates cellular signaling and transduction pathways by dephosphorylating its substrate.
Researchers have unveiled the precise brain mechanisms that enable animals to overcome instinctive fears. The study in mice could have implications for developing therapeutics for fear-related disorders such as phobias, anxiety and post-traumatic stress disorder (PTSD).
The small, Ireland-based company GH Research said its inhaled version of mebufotenin — a molecular cousin to psilocybin — was fast and effective in a treatment-resistant depression trial.
MONDAY, Feb. 3, 2025 -- A common drug used to prevent migraines might have an additional benefit -- protecting women against stroke. Women taking the beta blocker propranolol to ward off migraines have a lower risk of strokes caused by blood clots.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
A daily intake of one gram of omega-3s can slow down biological aging by up to four months, according to an analysis of clinical data from the international DO-HEALTH study. For the first time, epigenetic clocks were used to measure the aging process.
The biotech is evaluating several cystic fibrosis medicines that could either work alongside Vertex’s top-selling Trikafta or be used in new, multi-drug combinations.
WEDNESDAY, Feb. 5, 2025 -- Schizophrenia cases associated with problematic weed use have skyrocketed in the wake of Canada's legalization of marijuana, a new study says.The proportion of schizophrenia cases associated with cannabis use disorder.
Learn about the proportional odds assumption in clinical trials, its importance in ordinal regression, and key considerations for statistical analysis.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Boosting communication between the spinal nerves and the muscles using the spinal cord stimulation reverses spinal muscle atrophy (SMA) progression and could be applied to other motoneuron diseases, including ALS.
The results could sway U.S. regulators to convert Braftovi’s accelerated clearance in colorectal tumors into a full approval — boosting an oncology portfolio Pfizer is looking to for revenue growth.
THURSDAY, Feb. 6, 2025 -- The U.S. Food and Drug Administration has approved Onapgo (apomorphine hydrochloride) injection as the first and only subcutaneous apomorphine infusion device for the treatment of motor fluctuations in patients with.
The beginning of a new semester brings a fresh crop of aspiring researchers to institutions each fall and spring. Students learn how to navigate post-secondary education and gain knowledge around effective research methods, both practical and intangible. Student researchers, along with early career researchers (collectively referred to here as new researchers), begin to experience responsible conduct of research principles firsthand.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Ever notice how much more tempting it is to pick up fast food for dinner after being stuck in traffic? It's not just you. New research shows that traffic delays significantly increase visits to fast food restaurants, leading to unhealthier eating for millions each year.
WEDNESDAY, Feb. 5, 2025 -- Hopes that GLP-1 drugs such as Ozempic and Wegovy could help slow Parkinson's disease have taken an hit.A new study found that a drug in the same class called exenatide, marketed as Byetta, had no effect on slowing the.
AI in Action: Delivering Results in HCP Engagement dwunderlin Wed, 02/05/2025 - 14:16 Thu, 03/20/2025 - 11:00 Resource Type Webinar Matt Lehmann Adam Cahill AI is no longer a noveltyit's an expectation. As stakeholders demand evidence of real-world impact, the focus is shifting from the tools themselves to the tangible results they deliver. Join us for a dynamic discussion on how predictive sales intelligence and omnichannel strategies are transforming healthcare professional (HCP) engagement by
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
There's a 26 per cent annual chance that space rocket junk will re-enter the atmosphere and pass through a busy flight area, according to a recent study. While the chance of debris hitting an aircraft is very low, the research highlights that the potential for uncontrolled space rocket junk to disrupt flights and create additional costs for airlines and passengers is not.
Cobenfy, the main asset acquired through Bristol Myers’ $14 billion purchase of Karuna, had $10 million in sales in the fourth quarter and is around 1,000 prescriptions weekly by late January.
FRIDAY, Feb. 7, 2025 -- The Texas Department of State Health Services (DSHS) is reporting an outbreak of measles in Gaines County.All cases have been identified among unvaccinated school-aged children who are residents of Gaines County. Symptom.
At a busy research site, a clinical trial is ready to launch but its stuck in limbo over a single paragraph in the informed consent form (ICF). The issue? Language relating to the potential cost of participation. One sites language on what they will pay for differs from anothers, and the contradictory wording needs to be reviewed and agreed to by the sponsor before the IRB can proceed.
A researcher has discovered a new method to remove so-called 'forever chemicals' from our drinking water by heating the PFAS with granular activated carbon. The discovery represents a significant breakthrough in managing PFAS-containing solid wastes, biosolids and spent adsorbent media that are major concerns to farmers and communities.
“There is not a single member of AAM who has not raised concerns about the tariff situation,” said the CEO of the generic drug lobby Association for Accessible Medicines.
TUESDAY, Feb. 4, 2025 -- Many Americans dont see anything wrong with taking daily low-dose aspirin, even though experts have concluded its risks outweigh its benefits, a new survey has found.Nearly half (48%) of people incorrectly think that the b.
Introduction Contract Research Organisation (CRO) outsourcing has become a vital strategy for pharmaceutical and biotechnology companies aiming to optimise clinical research and drug development. Through partnerships with CROs, sponsors can access specialised expertise, reduce operational costs, and accelerate the time-to-market for new treatments. Understanding the various outsourcing models, their benefits, and the latest industry trends is essential for making informed decisions in CRO partne
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