Sat.Apr 13, 2024 - Fri.Apr 19, 2024

article thumbnail

DDW event focusses on rAAVs and long-read nanopore sequencing

Drug Discovery World

Join DDW for this exclusive free event, ‘ rAAV genome sequencing with Oxford Nanopore uncovers transgene integrity and packaging impurities ’. The event will be supported by Oxford Nanopore Technologies. The event will feature experts Daniel Jachimowicz, Senior Bioscience Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden, and Bastian Schiffthaler, Senior Data Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden.

DNA 246
article thumbnail

One third of China's urban population at risk of city sinking, new satellite data shows

Science Daily: Pharmacology News

Land subsidence is overlooked as a hazard in cities, according to new research. Scientists used satellite data that accurately and consistently maps land movement across China.

Research 139
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

Metsera, a well-funded obesity drug startup, sees chance to challenge Lilly, Novo

BioPharma Drive: Drug Pricing

It’s “early innings” in the obesity drug race, said Metsera CEO Clive Meanwell, whose company has acquired a portfolio of medicines it aims to test in combination.

Drugs 124
article thumbnail

Antipsychotics May Do Great Harm to People With Dementia: Report

Drugs.com

THURSDAY, April 18, 2024 -- Antipsychotics can substantially increase dementia patients’ risk of many serious health problems, a new study warns.

130
130
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Charles River launches initiative to reduce animal testing

Drug Discovery World

Charles River Laboratories International has launched its Alternative Methods Advancement Project (AMAP), an initiative focused on developing alternatives to reduce animal testing. The company has invested $200 million over the past four years to reduce the use of animal testing and has a five-year goal of investing an additional $300 million. AMAP initiatives include research projects confirming the safety and efficacy of alternatives – ensuring patient safety remains the priority.

article thumbnail

38 trillion dollars in damages each year: World economy already committed to income reduction of 19 % due to climate change

Science Daily: Pharmacology News

Even if CO2 emissions were to be drastically cut down starting today, the world economy is already committed to an income reduction of 19% until 2050 due to climate change, a new study finds. These damages are six times larger than the mitigation costs needed to limit global warming to two degrees. Based on empirical data from more than 1,600 regions worldwide over the past 40 years, scientists assessed future impacts of changing climatic conditions on economic growth and their persistence.

137
137

More Trending

article thumbnail

Dietary Changes May Beat Meds in Treating IBS

Drugs.com

FRIDAY, April 19, 2024 -- The right diet may be the best medicine for easing the painful symptoms of irritable bowel syndrome (IBS), new research shows. In the study, two different eating plans beat standard medications in treating the debilitating.

Research 116
article thumbnail

Turning science into business: Amplifying mRNA by targeting regRNAs

Drug Discovery World

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. DS: CAMP4 leverages research from co-founder Richard Young on how regulatory RNA (regRNA) molecules control the expression of genes.

Science 147
article thumbnail

Workings of working memory detailed

Science Daily: Pharmacology News

Investigators have discovered how brain cells responsible for working memory--the type required to remember a phone number long enough to dial it--coordinate intentional focus and short-term storage of information.

134
134
article thumbnail

Ultragenyx says Angelman therapy is working, but safety questions remain

BioPharma Drive: Drug Pricing

Treatment appeared to result in functional and cognitive gains in people with the neurological disorder. Three participants experienced lower extremity weakness, however.

Therapies 120
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Blood Test Might Someday Diagnose Early MS

Drugs.com

FRIDAY, April 19, 2024 -- An early marker of multiple sclerosis could help doctors figure out who will eventually fall prey to the degenerative nerve disease, a new study says.In one in 10 cases of MS, the body begins producing a distinctive set of.

Doctors 115
article thumbnail

2024 predictions: Experts weigh in on stem cells  

Drug Discovery World

DDW’s Megan Thomas speaks to experts from the drug discovery industry about their predictions on the future of stem cells in drug discovery. Melissa Little, CEO of the Novo Nordisk Foundation Centre for Stem Cell Medicine “In the stem cell space, 2023 has seen significant increases in the delivery of pluripotent stem cell-derived cell types into first-in-human clinical trials.

article thumbnail

Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Science Daily: Pharmacology News

Over a ten-year period, biobank participants who met recommended levels of physical activity had a 23% lower risk of cardiovascular disease, and the protective effects were even more pronounced in individuals with depression.

Disease 129
article thumbnail

Cerevel, in ‘major surprise,’ finds success in late-stage Parkinson’s study

BioPharma Drive: Drug Pricing

Analysts had low expectations for Cerevel’s drug tavapadon, which was something of an afterthought in AbbVie’s proposed buyout of the biotech.

Drugs 124
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Managing Blood Sugar After Stroke Could Be Key to Outcomes

Drugs.com

FRIDAY, April 19, 2024 -- Managing a stroke victim’s blood sugar levels after they receive powerful clot-busting drugs might help them survive their health crisis, a new trial finds.People with high blood sugar levels were more likely to suffer a.

Trials 115
article thumbnail

Advancing stability in cell line development 

Drug Discovery World

Roxana McCloskey , Senior Global Marketing Manager, Protein Therapeutics, SCIEX explores how innovative analytical approaches can help improve stability for cell line development. Cell line development (CLD) is a critical stage in the early production of biotherapeutic molecules. During the CLD stage, a key goal is to generate, identify and advance the most stable cell lines for the robust production of high-quality therapeutic molecules in large quantities.

article thumbnail

Can animals count?

Science Daily: Pharmacology News

Researchers have made a groundbreaking discovery regarding number sense in animals by confirming the existence of discrete number sense in rats, offering a crucial animal model for investigating the neural basis of numerical ability and disability in humans.

Research 125
article thumbnail

Roche wins FDA OK for targeted drug in early lung cancer

BioPharma Drive: Drug Pricing

The new label for Alecensa makes it the first targeted treatment available after surgery for people with ALK-positive lung tumors, who are at high risk for brain metastases.

FDA 112
article thumbnail

A-Fib Is Strong Precursor to Heart Failure

Drugs.com

FRIDAY, April 19, 2024 -- The dangerous heart rhythm disorder known as atrial fibrillation is mainly known for increasing people’s risk of stroke.But people with A-Fib actually have a much higher risk of developing heart failure than suffering a.

111
111
article thumbnail

This week in drug discovery (15-19 April) 

Drug Discovery World

News round-up for 15-19 April by DDW Digital Content Editor Diana Spencer. The headline news this week all concerns clinical trials for new drugs that could have a significant impact on future patient treatment, including trials testing therapeutics for ALS, cystic fibrosis, gonorrhoea, TB and Parkinson’s. The top stories: Drug candidate for ALS patients authorised for Phase II trial Axoltis Pharma has received authorisation from ANSM, the French agency for the safety of health products, to laun

article thumbnail

Microplastics make their way from the gut to other organs

Science Daily: Pharmacology News

Researchers have found that microplastics -- are having a significant impact on our digestive pathways, making their way from the gut and into the tissues of the kidney, liver and brain.

Research 124
article thumbnail

ChEMBL 34 is out!

The ChEMBL-og

We are delighted to announce the release of ChEMBL 34, which includes a full update to drug and clinical candidate drug data. This version of the database, prepared on 28/03/2024 contains: 2,431,025 compounds (of which 2,409,270 have mol files) 3,106,257 compound records (non-unique compounds) 20,772,701 activities 1,644,390 assays 15,598 targets 89,892 documents Data can be downloaded from the ChEMBL FTP site: [link] Please see ChEMBL_34 release notes for full details of all changes in this rel

article thumbnail

Two-Drug Combo Curbs Drinking for People Battling Severe Alcoholism

Drugs.com

THURSDAY, April 18, 2024 -- A combo of an allergy drug and a blood pressure med appears to lower daily drinking in folks battling severe alcoholism, French researchers report.

Drugs 111
article thumbnail

Gene therapy proved to be safe in patients with Parkinson’s disease

Drug Discovery World

Askbio’s AB-1005 (also known as AAV2-GDNF), an investigational gene therapy for the treatment of Parkinson’s disease, was well tolerated with no serious adverse events in a Phase Ib clinical trial. The data were presented at the American Academy of Neurology 2024 Annual Meeting in Denver, Colorado, USA. Based on the safety and efficacy results, a Phase II trial (REGENERATE PD) has been developed and is expected to begin enrolling in the US, EU, and UK later this year.

Therapies 130
article thumbnail

How 3D printers can give robots a soft touch

Science Daily: Pharmacology News

Soft skin coverings and touch sensors have emerged as a promising feature for robots that are both safer and more intuitive for human interaction, but they are expensive and difficult to make. A recent study demonstrates that soft skin pads doubling as sensors made from thermoplastic urethane can be efficiently manufactured using 3D printers.

121
121
article thumbnail

Perficient Included in IDC Market Glance: Payer, 2Q24

Perficient: Drug Development

Health insurers today are facing a rapidly evolving landscape of complex expectations and requirements. Whether it’s responding to government mandates regarding interoperability and data privacy or customer demand for a seamless digital experience, constant evolution is key to staying at the forefront of industry standards. Your future success will be determined by the investments you make now in your capabilities and technology.

Marketing 107
article thumbnail

Weight-loss Drug Zepbound Eases Sleep Apnea in Company Trials

Drugs.com

WEDNESDAY, April 17, 2024 -- Zepbound, one of the wildly popular weight-loss drugs that millions of Americans now take, eased sleep apnea in obese adults in two company trials, drug maker Eli Lilly announced Wednesday.First approved to treat.

Trials 111
article thumbnail

Partnership to speed up cell therapy delivery

Drug Discovery World

Autolomous and BioCentriq have collaborated to digitise and accelerate process development and manufacturing activities for cell therapy. Autolomous’ software platform is designed to materially affect the cell and gene therapy sector. BioCentriq will leverage the autoloMATE platform to streamline its process development operations and enhance client experience.

Therapies 130
article thumbnail

Evolution's recipe book: How 'copy paste' errors cooked up the animal kingdom

Science Daily: Pharmacology News

A series of whole genome and gene duplication events that go back hundreds of millions of years have laid the foundations for tissue-specific gene expression, according to a new study. The 'copy-paste' errors allowed animals to keep one copy of their genome or genes for fundamental functions, while the second copy could be used as raw material for evolutionary innovation.

121
121
article thumbnail

The immune system’s role in lung cancer risk

Drug Target Review

What were the key findings regarding the influence of HLA molecules on lung cancer risk? Dr Chowell : Heterozygosity at HLA-II, but not HLA-I, was found to be enriched in controls relative to cases with lung cancer and was associated with a reduced risk of developing lung cancer over time, as well as a reduced lifetime risk of lung cancer among former and current smokers but not among never-smokers.

article thumbnail

Birth Control Pill Might Lower Odds for Sports Injuries

Drugs.com

WEDNESDAY, April 17, 2024 -- Active women using the pill appear to receive an added bonus from their birth control, a new study says.These women are less likely to suffer sprains and strains than women not on birth control, researchers reported.

Research 111
article thumbnail

Human infection model drives forward TB vaccine development

Drug Discovery World

For the first time, a controlled human infection model for tuberculosis (TB) has been developed and could help with the future development of TB vaccines. Researchers from the University of Oxford developed the infection model, which replicates how TB enters the body by infecting people via the lung, using the bacille Calmette-Guerin (BCG) vaccine delivered via aerosol into participants’ lungs.

Vaccine 130
article thumbnail

Pyrite, also known as fool's gold, may contain valuable lithium, a key element for green energy

Science Daily: Pharmacology News

The technology revolution and development of new renewable energy resources is driving demand for lithium to new heights, but it is not a common mineral. Scientists say they have found lithium in an unexpected place; fool's gold, or pyrite, deposits.

120
120
article thumbnail

Exploring Blue Prism’s Web-Based Extension

Perficient: Drug Development

Empowering Automation in the Digital Era In this highly digitally connected world, companies are always looking for new and creative ways to improve efficiency, simplify procedures, and provide better customer service. Robotic Process Automation (RPA) has become a game-changing technology that helps businesses accelerate up operations, cut down on human error, and automate repetitive activities.