Broad Institute

JUNE 14, 2024

Some CRISPR screens may be missing cancer drug targets By Allessandra DiCorato June 14, 2024 Breadcrumb Home Some CRISPR screens may be missing cancer drug targets Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results. By Allessandra DiCorato June 14, 2024 Credit: Ricardo Job-Reese, Broad Communications CRISPR/Cas9 gene editing has made possible a multitude of biomedical experiments including studies that systematically t

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Science Daily: Pharmacology News

JUNE 11, 2024

The structure and function of the kidneys is altered by space flight, with galactic radiation causing permanent damage that would jeopardise any mission to Mars, according to a new study led by researchers from UCL.

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Research 137

Antidote

JUNE 10, 2024

Also known as endometrial carcinoma or uterine cancer, endometrial cancer occurs when the cells that line the uterus begin growing uncontrollably. Though the mortality rates are relatively low due to the high rate of early detection, it is a cancer that impacts nearly 70,000 people every year.

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Drugs.com

JUNE 10, 2024

MONDAY, June 10, 2024 -- An experimental vaccine that could offer one-stop prevention for both COVID-19 and influenza is showing positive results among older adults in trials, maker Moderna announced Monday.The shot — for now called mRNA-1083 — "ha.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Broad Institute

JUNE 10, 2024

Improved prime editing system makes gene-sized edits in human cells at therapeutic levels By Allessandra DiCorato June 10, 2024 Breadcrumb Home Improved prime editing system makes gene-sized edits in human cells at therapeutic levels The gene-editing approach uses prime editors and evolved enzymes called recombinases, and could pave the way to effective one-size-fits-all gene therapies for diseases such as cystic fibrosis.

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DNA Engineering Therapies Disease 144

Science Daily: Pharmacology News

JUNE 13, 2024

With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.

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FDA Law Blog: Biosimilars

JUNE 13, 2024

By Sara W. Koblitz — As we have noted for the last year or so, the FTC has been on a mission to clean up the Orange Book by removing what it deems to be “improper” patents. The FTC has put out policy statements, challenged patent listings, tapped Congress, appeared on talk shows, and filed amicus briefs all in the span of the last 8 months. It seems like all that work is paying off.

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Drugs.com

JUNE 14, 2024

FRIDAY, June 14, 2024 -- COVID vaccine makers will be advised to update their shots to target the KP.2 variant, an offshoot of the JN.1 variant that spread widely last winter, the U.S. Food and Drug Administration announced Thursday. It's a.

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Vaccine FDA Drugs 115

Science Daily: Pharmacology News

JUNE 13, 2024

A lack of sleep can make it extraordinarily difficult to retain information. Two new studies uncover why this is and what is happening inside the brain during sleep and sleep deprivation to help or harm the formation of memories.

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BioPharma Drive: Drug Pricing

JUNE 12, 2024

The negative results from the Phase 3 study, called Ciffreo, come a little more than a month after Pfizer said a patient died in another trial of the gene therapy.

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Therapies Trials 114

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

FDA Law Blog: Biosimilars

JUNE 12, 2024

By Sara W. Koblitz & Jeffrey N. Gibbs — It’s been over a year and a half since Over-the-Counter (“OTC”) hearing aids became legal, and it’s not clear that they’ve made the difference in hearing loss treatment that Congress anticipated. (FDA once estimated that OTC hearing aids would save patients over $3000.) A recent GAO Report hasn’t found that OTC hearing aids have had much impact.

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Drugs.com

JUNE 13, 2024

THURSDAY, June 13, 2024 -- Two human cases of "dual mutant" strains of H1N1 flu have been reported by U.S. health officials.Unfortunately, the genetic changes appear to render the leading flu antiviral, Tamiflu, less effective, researchers from the.

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Virus Treatment Research 113

Science Daily: Pharmacology News

JUNE 12, 2024

Researchers have demonstrated a new method that leverages artificial intelligence (AI) and computer simulations to train robotic exoskeletons to autonomously help users save energy while walking, running and climbing stairs.

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Research 135

BioPharma Drive: Drug Pricing

JUNE 12, 2024

Study results indicated Avidity’s medicine muted target genes. Elsewhere, Syntis revealed obesity drug plans and Nodthera chalked up more positive data for its NLRP3 inhibitor.

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Drugs 112

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Clinical Trials

FDA Law Blog: Biosimilars

JUNE 10, 2024

By Sarah Wicks & Anne K. Walsh — Among FDA-regulated establishments and stakeholders, there is one word that makes everyone go on edge – the dreaded FDA “inspection.” In an effort to clarify for industry and alleviate some of the stress associated with these activities, last week the FDA issued a draft guidance aimed at providing recommendations on how to handle inspections under FDA’s Bioresearch Monitoring (BIMO) program.

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Drugs.com

JUNE 14, 2024

FRIDAY, June 14, 2024 -- The two top officers of a telehealth company that began to distribute ADHD drugs widely during the pandemic have been charged with health care fraud, the U.S. Department of Justice announced Thursday. The arrests will.

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Drugs 111

Science Daily: Pharmacology News

JUNE 11, 2024

Researchers have demonstrated miniature soft hydraulic actuators that can be used to control the deformation and motion of soft robots that are less than a millimeter thick. The researchers have also demonstrated that this technique works with shape memory materials, allowing users to repeatedly lock the soft robots into a desired shape and return to the original shape as needed.

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Research 133

BioPharma Drive: Drug Pricing

JUNE 11, 2024

The medicine will join Intercept’s Ocaliva as a treatment option for primary biliary cholangitis. Another drug, from the now Gilead-owned CymaBay, could be cleared for the condition by August.

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Clinical Trials

Drug Patent Watch

JUNE 12, 2024

Sure, here’s a more detailed explanation with examples: Drug Patent Duration Drug patents are granted by the United States Patent and Trademark Office (USPTO) for a period of 20 years… Source

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Drugs 111

Drugs.com

JUNE 10, 2024

MONDAY, June 10, 2024 — Though overdose deaths continue to surge, there is no approved medication to treat methamphetamine use disorder.Now, an experimental two-drug therapy has yielded promising results, UCLA researchers report."These findings h.

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Science Daily: Pharmacology News

JUNE 11, 2024

Researchers are breaking through the difficulties of robotic recognition of various common, yet complex, items. Their layered sensor is equipped with material detection at the surface and pressure sensitivity at the bottom, with a porous middle layer sensitive to thermal changes. An efficient cascade classification algorithm rules out object types in order, from easy to hard, starting with simple categories like empty cartons before moving on to orange peels or scraps of cloth.

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Research 133

BioPharma Drive: Drug Pricing

JUNE 11, 2024

Newer components and drug combinations could expand use of the targeted cancer medicines, according to company executives.

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Drugs 107

Drug Patent Watch

JUNE 10, 2024

In the “Patent Effect” podcast, Mustafa introduces his guest, Hakan Yum, the IP Director of Exrain Pharma, based in Sweden.

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Drugs.com

JUNE 13, 2024

THURSDAY, June 13, 2024 -- CAR-T cell therapy to treat blood cancers is safer than previously thought, with little risk that the immunotherapy will create secondary cancers, a new study finds.The U.S. Food and Drug Administration issued a warning.

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Therapies Drugs 110

Science Daily: Pharmacology News

JUNE 12, 2024

Flexible piezoelectric sensors are essential to monitor the motions of both humans and humanoid robots. However, existing designs are either are costly or have limited sensitivity. In a recent study, researchers tackled these issues by developing a novel piezoelectric composite material made from electrospun polyvinylidene fluoride nanofibers combined with dopamine.

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Research 131

BioPharma Drive: Drug Pricing

JUNE 12, 2024

Kenneth Mills will become chair of the gene therapy developer's board while Curran Simpson, the current chief operating officer, will take his place as company head.

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Therapies 104

ASPET

JUNE 12, 2024

Mutations in the GNAO1 gene, which encodes the abundant brain G-protein Gα o , result in neurologic disorders characterized by developmental delay, epilepsy, and movement abnormalities. There are over 50 mutant alleles associated with GNAO1 disorders; the R209H mutation results in dystonia, choreoathetosis, and developmental delay without seizures.

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Drugs.com

JUNE 11, 2024

TUESDAY, June 11, 2024 -- A U.S. Food and Drug Administration advisory panel voted unanimously on Monday to recommend that the benefits of a new drug for Alzheimer's outweigh its harms, which can include brain swelling and bleeding. Eli Lilly's.

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FDA Drugs 110

Science Daily: Pharmacology News

JUNE 12, 2024

Engineers have developed microscopic robots, known as microrobots, capable of swimming through the lungs to deliver cancer-fighting medication directly to metastatic tumors. This approach has shown promise in mice, where it inhibited the growth and spread of tumors that had metastasized to the lungs, thereby boosting survival rates compared to control treatments.

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BioPharma Drive: Drug Pricing

JUNE 10, 2024

The expert committee concluded donanemab’s benefits outweigh its risks, despite some concern over the drug’s safety.

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FDA Drugs 103

Chemical Biology and Drug Design

JUNE 11, 2024

In this study, we explored the mechanism of action of brusatol in hepatocellular carcinoma. Using RNA-seq and through in vitro and in vivo studies, we determined that brusatol suppresses hepatocellular carcinoma progression by inducing ATF3-mediated ferroptosis. Therefore, our research revealed the biological effect of brusatol treatment and provided ATF3 as a novel therapeutic target and prognostic biomarker for HCC therapy.

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Drugs.com

JUNE 13, 2024

THURSDAY, June 13, 2024 -- Bipolar disorder doesn’t have to be a lifelong challenge, a new study says.Nearly 1 in 4 people with bipolar disorder wind up achieving complete mental health, researchers found.Further, more than 2 in 5 become free from b.

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Research 106

Science Daily: Pharmacology News

JUNE 10, 2024

Researchers have demonstrated the first chip-based 3D printer, a tiny device that emits reconfigurable beams of visible light into a well of resin that rapidly cures into a solid shape. The advance could enable a 3D printer small enough to fit in the palm of a person's hand.

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Research 127