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When we're told 'This coffee is hot' upon being served a familiar caffeinated beverage at our local diner or cafe, the message is clear. But what about when we're told 'This coffee is not hot'? Does that mean we think it's cold? Or room temperature? Or just warm? A team of scientists has now identified how our brains work to process phrases that include negation (i.e., 'not'), revealing that it mitigates rather than inverts meaning -- in other words, in our minds, negation merely reduces the tem
WEDNESDAY, May 29, 2024 -- People battling advanced colon cancers might have a new treatment option that could extend their survival, a new trial finds.A combination of two experimental immunotherapy drugs plus standard chemotherapy led to a median.
A partnership between cell therapy delivery specialist Portal Biotechnologies and precision robotics maker Multiply Labs could address manufacturing hurdles, the CEOs said.
Gary Tin, Marko Cigler, Matthias Hinterndorfer, Kevin D. Dong, Hana Imrichova, Steven P. Gygi, Georg E. Winter, Bioorganic & Medicinal Chemistry Letters , 2024 [link] Targeted protein degradation is mediated by small molecules that induce or stabilize protein–protein interactions between targets and the ubiquitin–proteasome machinery. Currently, there remains a need to expand the repertoire of viable E3 ligases available for hijacking.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Researchers have shown that members of the public have little trouble in learning very quickly how to use a third thumb -- a controllable, prosthetic extra thumb -- to pick up and manipulate objects. The team tested the robotic device on a diverse range of participants, which they say is essential for ensuring new technologies are inclusive and can work for everyone.
MONDAY, May 27, 2024 -- If you're one of the millions of Americans walking around with a new knee or hip, your odds for an infection in that joint rise if you ever have to undergo cancer chemotherapy, researchers report.“Given the number of people o.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
José O. Castellón, Samuel Ofori, Nikolas R. Burton, Ashley R. Julio, Alexandra C. Turmon, Ernest Armenta, Carina Sandoval, Lisa M. Boatner, Evan E. Takayoshi, Marina Faragalla, Cameron Taylor, Ann L. Zhou, Ky Tran, Jeremy Shek, Tianyang Yan, Heta S. Desai, Oliver I. Fregoso, Robert Damoiseaux, and Keriann M. Backus Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c12240 Caspases are a highly conserved family of cysteine-aspartyl proteases known for their essential roles in regula
WEDNESDAY, May 29, 2024 -- Allowing pharmacists to treat minor illnesses could potentially expand health care access to more people and save millions of dollars, a new study suggests.Care for a range of minor health issues -- urinary tract.
Ahead of an advisory panel meeting, agency staff identified several sticking points in the clinical results backing Lykos’ ecstasy-based treatment for PTSD.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Saidbakhrom Saidjalolov, Filipe Coelho, Vincent Mercier, Dimitri Moreau, and Stefan Matile ACS Central Science 2024 10 (5), 1033-1043 DOI: 10.1021/acscentsci.3c01601 Thiol-mediated uptake (TMU) is an intriguing enigma in current chemistry and biology. While the appearance of cell-penetrating activity upon attachment of cascade exchangers (CAXs) has been observed by many and is increasingly being used in practice, the molecular basis of TMU is essentially unknown.
THURSDAY, May 30, 2024 -- Newer epilepsy drugs taken while pregnant won’t affect the creative thinking of children, an effect that had been observed in older medications, a new study reports.Researchers found no difference in creativity scores at a.
The Series B funding from Two Sigma Ventures, RA Capital and others will help Gameto develop technology it says could replace hormonal injections and shorten the IVF process.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Colorectal cancer, often shortened just to colon cancer, is the third most commonly diagnosed cancer in the United States aside from skin cancers. While there are treatments available, including radiation and chemotherapy, the most important aspect of successful treatment is early detection — which is why knowing the colon cancer screening guidelines is essential.
Fossils found on the shoreline of Lake Kariba in Zimbabwe represent a completely new dinosaur species. This remarkable find, named Musankwa sanyatiensis, marks only the fourth dinosaur species named from Zimbabwe.
TUESDAY, May 24, 2024 -- Following two years of tough negotiations, efforts to craft a global treaty to help countries fight future pandemics have failed, the World Health Organization has acknowledged."WHO Member States have ended intensive.
The deal involves royalties for a brain cancer drug Agios previously sold off and that Royalty Pharma thinks could generate more than $1 billion in U.S. sales.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
One may choose to participate in a clinical trial for many reasons. Volunteering often has multiple benefits, from advancing medical research to gaining access to cutting-edge medical care. However, deciding to enroll in a clinical trial is only one part of the process.
Reaserchers have created a prototype for what they call 'living bioelectronics': a combination of living cells, gel, and electronics that can integrate with living tissue. Tests in mice found that the devices could continuously monitor and improve psoriasis-like symptoms, without irritating skin.
WEDNESDAY, May 29, 2024 -- A 4,000-year-old skull provides evidence that ancient Egyptians might have tried to treat cancer, a new study claims.Microscopic observation of the skull revealed 30 or so lesions scattered across its surface that are.
The $73 million round for CinRx Pharma, which created a startup AstraZeneca bought last year, will help fund subsidiaries making drugs for obesity, irritable bowel syndrome and gastroparesis.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Quality innovation is not for the weak at heart! Innovation myths may have you thinking it is for the lucky or the extremely talented – that’s not true. Pablo Picasso said, “Inspiration exists, but it has to find you working.” Thomas Edison quipped, “Opportunity is missed by most people because it is dressed in overalls and looks like work.” In this blog post, I want to focus on a different quote with the same intent.
Over the last two years, scientists have used NASA's James Webb Space Telescope to explore what astronomers refer to as Cosmic Dawn -- the period in the first few hundred million years after the big bang where the first galaxies were born.
TUESDAY, May 28, 2024 -- A small urban garden can contribute to your health, especially if the garden contains rich soil, a new study shows.A one-month indoor gardening period increased the bacterial diversity of participants’ skin and appeared to i.
London, 25/04/2024: The lab industry’s largest annual trade show is returning to the NEC, Birmingham, on October 30 and 31, 2024, to showcase sustainability and the latest innovations from the lab industry. The highly anticipated event will see thousands of attendees from across the lab sector descend on the NEC to meet with over 200 of the industry’s leading companies and enjoy the show’s world-leading conference programme, hosted across four free-to-attend theatres.
Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of g
WEDNESDAY, May 29, 2024 -- A bilingual brain implant has allowed a stroke survivor to communicate in both Spanish and English, scientists report. Turning to an AI method known as a neural network, researchers trained the patient's implant to.
The company is prioritizing development of an earlier so-called FcRn inhibitor, a type of medicine that’s shown promise treating multiple inflammatory conditions.
If you’re depositing a pooled library with Addgene, you may be surprised to learn that we ask for an amplification protocol with your deposit. This is because repeated amplifications of pooled libraries can lead to issues such as recombination and loss of plasmid diversity, so Addgene strives to distribute aliquots of the original library whenever possible.
According to a recent study, dogs trained to detect scent may be able to identify significantly lower concentrations of odour molecules than has previously been documented.
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