Sat.May 25, 2024 - Fri.May 31, 2024

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Jaguar Health out-licenses plant-based drug for schizophrenia

Drug Discovery World

Jaguar Health’s out-licensing agreement with Magdalena Biosciences to develop novel, natural prescription medicines derived from plants for mental health indications, has been expanded. The agreement now includes the ethnobotanical know-how related to development of a prescription drug compound from a specified medicinal plant for possible schizophrenia and psychoses indications and for development with potential corporate partners.

Licensing 147
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Lab Innovations 2024 to champion sustainability and innovation

Drug Discovery Today

London, 25/04/2024: The lab industry’s largest annual trade show is returning to the NEC, Birmingham, on October 30 and 31, 2024, to showcase sustainability and the latest innovations from the lab industry. The highly anticipated event will see thousands of attendees from across the lab sector descend on the NEC to meet with over 200 of the industry’s leading companies and enjoy the show’s world-leading conference programme, hosted across four free-to-attend theatres.

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On National Cancer Survivors Day, celebrating the power of research

Antidote

This Sunday, June 2, is National Cancer Survivors Day , designed to be a celebration for those who have survived cancer and an inspiration for those recently diagnosed. Since 1991, the national cancer death rate has dropped by 33% , partially due to advancements in treatment, early detection, and reduced smoking rates.

Research 119
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How does 'not' affect what we understand? Scientists find negation mitigates our interpretation of phrases

Science Daily: Pharmacology News

When we're told 'This coffee is hot' upon being served a familiar caffeinated beverage at our local diner or cafe, the message is clear. But what about when we're told 'This coffee is not hot'? Does that mean we think it's cold? Or room temperature? Or just warm? A team of scientists has now identified how our brains work to process phrases that include negation (i.e., 'not'), revealing that it mitigates rather than inverts meaning -- in other words, in our minds, negation merely reduces the tem

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Study finds dual receptor beta-agonist promotes healthy weight loss

Drug Discovery World

A new research paper has validated the mechanism of action of the Atrogi’s first-in-class, small molecule, ATR-127, in combating obesity and metabolic complications. Unlike existing anti-obesity therapies that compromise lean muscle mass, ATR-127 induces significant weight loss while preserving crucial lean body mass. ATR-127 binds to both the beta-2 and beta-3 adrenergic receptors in a unique manner, allowing for precise modulation of downstream signalling cascades.

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Combo Therapy Boosts Survival for Advanced Colon Cancer

Drugs.com

WEDNESDAY, May 29, 2024 -- People battling advanced colon cancers might have a new treatment option that could extend their survival, a new trial finds.A combination of two experimental immunotherapy drugs plus standard chemotherapy led to a median.

Therapies 119

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Your Idea Factory – Quality Innovation from Quantity

Perficient: Drug Development

Quality innovation is not for the weak at heart! Innovation myths may have you thinking it is for the lucky or the extremely talented – that’s not true. Pablo Picasso said, “Inspiration exists, but it has to find you working.” Thomas Edison quipped, “Opportunity is missed by most people because it is dressed in overalls and looks like work.” In this blog post, I want to focus on a different quote with the same intent.

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Vaccines and various response rates

Drug Discovery World

DDW Editor Reece Armstrong speaks to Dr Katrina Pollock from the Oxford Vaccine Group at the University of Oxford. Dr Pollock is the Chief Investigator of the LEGACY03 clinical trial, a study aiming to investigate lymph nodes and vaccination responses across age groups. RA: Could you tell us about the LEGACY03 trial? KP: The LEGACY03 study aims to understand how we respond to vaccines and how this changes as we age.

Vaccine 147
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Musankwa sanyatiensis, a new dinosaur from Zimbabwe

Science Daily: Pharmacology News

Fossils found on the shoreline of Lake Kariba in Zimbabwe represent a completely new dinosaur species. This remarkable find, named Musankwa sanyatiensis, marks only the fourth dinosaur species named from Zimbabwe.

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Understanding colon cancer screening guidelines

Antidote

Colorectal cancer, often shortened just to colon cancer, is the third most commonly diagnosed cancer in the United States aside from skin cancers. While there are treatments available, including radiation and chemotherapy, the most important aspect of successful treatment is early detection — which is why knowing the colon cancer screening guidelines is essential.

Treatment 119
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Strategy with Cyclophosphamide Could Expand Stem Cell Donor Pool for People Battling Blood Cancers

Drugs.com

TUESDAY, May 28, 2024 -- An older drug used in a new way could open the path for more patients with potentially deadly blood cancers to receive a lifesaving stem cell transplant, a new study finds. The drug, cyclophosphamide, could help patients.

Drugs 111
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How to get the biopharma deal you want

Drug Discovery World

Dr Neela Patel, Chief Business Officer at Bonum Therapeutics, offers advice on how to negotiate a winning deal in biopharma that meets investors’, buyers’ and sellers’ goals. Business development (BD) is an essential ingredient to the success of early-stage companies, whether they plan to exit through M&A, IPO, or have other mechanisms to return money to investors.

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NASA's James Webb Space Telescope finds most distant known galaxy

Science Daily: Pharmacology News

Over the last two years, scientists have used NASA's James Webb Space Telescope to explore what astronomers refer to as Cosmic Dawn -- the period in the first few hundred million years after the big bang where the first galaxies were born.

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Can robots break the cell therapy bottleneck?

BioPharma Drive: Drug Pricing

A partnership between cell therapy delivery specialist Portal Biotechnologies and precision robotics maker Multiply Labs could address manufacturing hurdles, the CEOs said.

Therapies 108
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Scientists Developing mRNA-Based Vaccine Against H5N1 Bird Flu

Drugs.com

TUESDAY, May 28, 2024 -- An experimental mRNA vaccine against the H5N1 avian flu is highly effective in preventing severe illness and death in lab animals, researchers report.The vaccine could help fight the H5N1 bird flu outbreaks now spreading in.

Vaccine 110
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New drug could prevent sepsis-related organ failure

Drug Discovery World

A new drug could prevent sepsis-related organ failure and death by restoring the health of a patient’s blood vessels. Researchers from The University of Queensland and the Queensland Children’s Hospital (QCH) have successfully tested the first-in-class drug in mice. Dr Mark Coulthard from UQ and the QCH’s Paediatric Intensive Care Unit said: “The reason for organ failure in sepsis patients is because the endothelial cells lining blood vessels become leaky, resulting in abnormal fluid shifts whic

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Scientists invent 'living bioelectronics' that can sense and heal skin

Science Daily: Pharmacology News

Reaserchers have created a prototype for what they call 'living bioelectronics': a combination of living cells, gel, and electronics that can integrate with living tissue. Tests in mice found that the devices could continuously monitor and improve psoriasis-like symptoms, without irritating skin.

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Perficient @ The 2024 Michigan Kidney Walk

Perficient: Drug Development

On Sunday, May 19th, 2024, 21 individuals consisting of Perficient employees and their family members, participated in the 2024 Michigan Kidney Walk at the Detroit Zoo. This annual event aims to raise funds for the National Kidney Foundation, an organization that provides critical support to those affected by kidney disease. A Tradition of Giving This year marked our third consecutive participation in the Kidney Walk.

Disease 98
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Had a Joint Replaced? Your Infection Risk May Rise After Chemotherapy

Drugs.com

MONDAY, May 27, 2024 -- If you're one of the millions of Americans walking around with a new knee or hip, your odds for an infection in that joint rise if you ever have to undergo cancer chemotherapy, researchers report.“Given the number of people o.

Research 111
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This week in drug discovery (27-31 May) 

Drug Discovery World

News round-up for 27-31 May by DDW Senior Digital Content Editor Diana Spencer. The selected news highlights this week report breakthrough findings from early phase research and development, mainly preclinical studies and Phase I clinical trials, including a drug that can prevent sepsis deaths, a microbiome based immuno-oncology candidate, and a plant-based therapy for diarrhoea.

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Public have no difficulty getting to grips with an extra thumb, study finds

Science Daily: Pharmacology News

Researchers have shown that members of the public have little trouble in learning very quickly how to use a third thumb -- a controllable, prosthetic extra thumb -- to pick up and manipulate objects. The team tested the robotic device on a diverse range of participants, which they say is essential for ensuring new technologies are inclusive and can work for everyone.

Research 112
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New patent for Corcept Therap drug KORLYM

Drug Patent Watch

Annual Drug Patent Expirations for KORLYM Korlym is a drug marketed by Corcept Therap and is included in one NDA. It is available from one supplier.

Drugs 104
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For Minor Health Issues, Pharmacist Care May Be the Low-Cost Option

Drugs.com

WEDNESDAY, May 29, 2024 -- Allowing pharmacists to treat minor illnesses could potentially expand health care access to more people and save millions of dollars, a new study suggests.Care for a range of minor health issues -- urinary tract.

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Veridix AI targets biobanks with real-time specimen tracking technology

Drug Discovery World

GlobalTrace, the specimen tracking and chain of custody solution from Veridix AI – the technology arm of the Emmes Group – is now being offered to global customers as a standalone service. The CRO expects new markets to be a key part of its growth strategy, as biobanking and related biospecimen shipping services seek more robust solutions, particularly as a new report highlights the risk factors associated with current inventory management approaches.

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People are altering decomposition rates in waterways

Science Daily: Pharmacology News

Humans may be accelerating the rate at which organic matter decomposes in rivers and streams on a global scale, according to a new study. That could pose a threat to biodiversity in waterways around the world and increase the amount of carbon in Earth's atmosphere, potentially exacerbating climate change. The study is the first to combine a global experiment and predictive modeling to illustrate how human impacts to waterways may contribute to the global climate crisis.

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Pooled Library Amplifications

addgene Blog

If you’re depositing a pooled library with Addgene, you may be surprised to learn that we ask for an amplification protocol with your deposit. This is because repeated amplifications of pooled libraries can lead to issues such as recombination and loss of plasmid diversity, so Addgene strives to distribute aliquots of the original library whenever possible.

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Almost 1 in 3 Americans Know Someone Who's Died From a Drug Overdose

Drugs.com

FRIDAY, May 31, 2024 -- As the opioid addiction crisis continues to lay waste to American life, a new survey finds that nearly a third of U.S. adults now know someone who's died of a drug overdose. Conducted in the spring of 2023, the survey of.

Drugs 105
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Register for this AI, ML and lab automation webinar now

Drug Discovery World

In this free webinar , hosted by DDW and sponsored by Benchling, you will learn about technology through the lens of artificial intelligence (AI), machine learning and lab automation. It will take place on 11 June from 3:00 PM – 4:00 PM BST. You will hear from Jonathan Wingfield, Principal Scientist at AstraZeneca; Abraham Heifets, CEO at Atomwise; Raminderpal Singh, AI Expert at HitchhikersAI; and a joint presentation from Helen Liu-Mayo, Product Manager, Machine Learning at Benchling, an

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Scent detection dogs discern odour molecules better than previously thought

Science Daily: Pharmacology News

According to a recent study, dogs trained to detect scent may be able to identify significantly lower concentrations of odour molecules than has previously been documented.

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Health Insurer Trends to Watch at AHIP 2024

Perficient: Drug Development

Health insurers from every corner of the country are set to assemble in Las Vegas for the 2024 AHIP conference —and here at Perficient, we’re excited to have two of our colleagues attending as well. At AHIP 2024, thought leaders will address some of the industry’s most pressing questions, and the conference will feature educational sessions, Q&As, and networking opportunities.

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Will Epilepsy Meds Taken in Pregnancy Affect a Child's Creativity?

Drugs.com

THURSDAY, May 30, 2024 -- Newer epilepsy drugs taken while pregnant won’t affect the creative thinking of children, an effect that had been observed in older medications, a new study reports.Researchers found no difference in creativity scores at a.

Drugs 105
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Drug candidate for apathy enters Phase I trials

Drug Discovery World

Swedish company IRLAB Therapeutics has initiated a Phase I study of IRL757, its drug candidate for apathy – a condition associated with Parkinson’s disease and other CNS diseases. IRL757 has shown positive effects in several preclinical models of cognitive function, including improved motivation. This effect is believed to be associated with the drug candidate’s unique ability to counteract disturbances in nerve signalling that are believed to cause apathy in several neurological dis

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In the brain at rest, neurons rehearse future experience

Science Daily: Pharmacology News

New research sheds light on how individual neurons in the hippocampus of rats stabilize and tune spatial representations during periods of rest following the animals' first time running a maze, offering first proof of neuroplasticity during sleep.

Research 101
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Antibodies 101: Designing Your First Flow Panel

addgene Blog

When analyzing your cells using flow cytometry, you are typically measuring the presence or absence of certain markers on the surface or the inside of your cells. While proteins themselves can emit intrinsic fluorescence when excited with ultraviolet (UV) light, they do so via aromatic amino acids found in all proteins, so you can't distinguish the different proteins from each other.

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