Sat.Apr 20, 2024 - Fri.Apr 26, 2024

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Concussion drug therapies on the horizon

Drug Discovery World

Michael Wyand, PhD, Chief Executive Officer/Director, Oxeia Biopharmaceuticals explains why there’s a need for new drugs to treat traumatic brain injuries. Whereas once it was thought that mild traumatic brain injuries were harmless and symptoms would disappear after a few days of rest, we now know that rest is not enough – these are a major and ongoing public health issue.

Therapies 147
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Vancomycin May Be Losing Strength Against Common Deadly Infection

Drugs.com

FRIDAY, April 26, 2024 -- Clostridioides difficile (C. difficile) is a leading cause of illness and death, especially for frail and hospitalized Americans. Now, a new study suggests that the leading antibiotic used to fight it, vancomycin, may be.

Hospitals 137
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Cells may possess hidden communication system

Science Daily: Pharmacology News

Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.

Research 137
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A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic By Allessandra DiCorato April 25, 2024 Breadcrumb Home A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic Scientists from the US and West Africa have teamed up to build a better public health network that can quickly detect and respond to emerging viral threats.

Virus 132
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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This week in drug discovery (22-26 April) 

Drug Discovery World

News round-up for 22-26 April by DDW Digital Content Editor Diana Spencer. The leading news story this week has been the launch of a new clinical trial in the UK for a melanoma personalised mRNA cancer vaccine, but there have been a number of other interesting developments in cancer drug discovery. These include the detection of new targets for skin cancer treatment, the benefits of vitamin D for cancer prevention, an extended approval in the EU for a CAR-T myeloma therapy and the discovery of a

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Science Reveals How Aspirin Prevents Colon Cancer

Drugs.com

WEDNESDAY, April 24, 2024 -- Long-term daily use of aspirin has been known to prevent colon cancer, but up to now it’s been unclear why that is.Now, researchers think they understand how aspirin acts against colon cancer, a new study says.Aspirin.

Science 124

More Trending

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Workers’ Memorial Day 2024: Statement by NIOSH Director

NIOSH Science Blog: Drugs

Each year, on April 28, we pause to recognize Workers’ Memorial Day and honor those whose death or suffering resulted from exposure to hazards at work. Words are not enough when it comes to change. Research has shown that the health and safety of workers relies on active and intentional involvement in ways that take into consideration workplace hazards, work arrangements and environment, employer-worker relationships, the workers themselves, and their families.

Research 114
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CN Bio raises $21 million in Series B investment round

Drug Discovery World

Organ-on-a-chip (OOC) company CN Bio has raised a $21 million investment in the first close of its Series B fundraising round. The funding has been secured from several new investors; including $10 million from Bayland Capital, and $5.5 million from founding shareholder, CN Innovations Holdings Ltd. The investment will be used to accelerate the company’s expanding product portfolio and to scale the business to support commercial expansion across key global markets.

FDA 130
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Few Young Adults Could Administer Naloxone to Reverse Fentanyl Overdose

Drugs.com

MONDAY, April 22, 2024 -- Even though fentanyl-linked fatal overdoses are soaring among young adults, a new survey of American college students found that just 1 in 7 knew how to administer the overdose antidote drug naloxone.Many who took the.

Drugs 122
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With hybrid brains, these mice smell like a rat

Science Daily: Pharmacology News

Mice lacking an olfactory system have had their sense of smell restored with neurons from rats, the first time scientists have successfully integrated the sensory apparatus of one species into another.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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What is health literacy? Definition and resources

Antidote

Equitable access to medical care is valuable for everyone, and an important part of this equation is health literacy. Health literacy encompasses not just access to medical care, but also the ability to understand and use medical guidance. This can include anything from a doctor’s suggestions, to medication dosage information, and aftercare guidance.

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“Game-changing” personalised cancer vaccine enters UK clinical trials   

Drug Discovery World

A clinical trial of a personalised mRNA cancer vaccine for melanoma patients has been launched in the UK. As reported by The Guardian , the global Phase III clinical trial is being led by University College London Hospitals NHS Foundation Trust (UCLH) and will include around 1,100 people, with the UK arm taking place across eight centres in the UK.

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New Rules Mean 3.6 Million Americans Could Get Wegovy Via Medicare, Costing Billions

Drugs.com

WEDNESDAY, April 24, 2024 -- A budget-busting 3.6 million Medicare recipients could now be eligible for coverage of the weight-loss drug Wegovy, a new KFF analysis says.That’s because the U.S. Food and Drug Administration has approved the use of.

Drugs 119
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Use of acid reflux drugs linked to higher risk of migraine

Science Daily: Pharmacology News

People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, such as cimetidine and famotidine, and antacid supplements.

Drugs 123
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Why Nothing Can Grow on Mars*

Codon

(* = probably.) Two years ago, a friend took me out to coffee in Boston and said, “I think we can engineer an organism to terraform Mars.” Terraforming—transforming a planet so it can support life—has been the perennial dream of science-fiction authors and futurists, who, from Isaac Asimov to Kim Stanley Robinson, envisioned humanity inhabiting a multi-planetary civilization.

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Vitamin D boosts ‘good’ bacteria and improves immunity to cancer

Drug Discovery World

Researchers have found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer. The researchers from the Francis Crick Institute, the National Cancer Institute (NCI) of the US National Institutes of Health (NIH) and Aalborg University in Denmark, found that mice given a diet rich in vitamin D had better immune resistance to experimentally transplanted cancers and improved responses to immunotherapy treatment.

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Trying 'Magic Mushroom' Drug to Ease Depression? It Has Side Effects

Drugs.com

WEDNESDAY, April 24, 2024 -- Many people with tough-to-treat depression may be trying psilocybin, the active ingredient in magic mushrooms, as an alternative to antidepressants.Thinking that it's a "natural" drug, folks might assume it comes.

Drugs 116
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Why can't robots outrun animals?

Science Daily: Pharmacology News

Robotics engineers have worked for decades and invested many millions of research dollars in attempts to create a robot that can walk or run as well as an animal. And yet, it remains the case that many animals are capable of feats that would be impossible for robots that exist today.

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Pfizer hemophilia gene therapy arrives in US to uncertain future

BioPharma Drive: Drug Pricing

The Food and Drug Administration approval of Beqvez comes as other gene therapies for the bleeding condition that were approved earlier struggle to gain traction.

Therapies 116
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New podcast looks behind the scenes of the drug discovery industry

Drug Discovery World

This is the latest episode of the free DDW narrated podcast, titled “A look behind the scenes of the drug discovery industry” which covers three written for Volume 23 – Issue 4, Fall 2022 of DDW. They are called: Going paperless – the move to electronic lab notebooks , New horizon for cancer innovation , and A personal touch: the role of bioprinting in drug discovery.

Drugs 130
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Neosporin Ointment in the Nose Might Be Potent Antibiotic

Drugs.com

TUESDAY, April 23, 2024 -- Want to prevent a respiratory infection?A fingerful of Neosporin antibiotic swabbed inside your nose might help you fight off a range of invading respiratory viruses, a new study claims.Lab animals whose noses were.

Virus 116
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Holographic displays offer a glimpse into an immersive future

Science Daily: Pharmacology News

Researchers have invented a new optical element that brings us one step closer to mixing the real and virtual worlds in an ordinary pair of eyeglasses using high-definition 3D holographic images.

Research 116
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Innovative Strategies in Drug Repurposing

Drug Patent Watch

Drug repurposing, or identifying new therapeutic uses for existing drugs, is gaining significant momentum as a promising approach to accelerate drug development and reduce costs.

Drugs 111
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A look behind the scenes of the drug discovery industry

Drug Discovery World

This is the latest episode of the free DDW narrated podcast, titled “A look behind the scenes of the drug discovery industry” which covers three written for Volume 23 – Issue 4, Fall 2022 of DDW. They are called: Going paperless – the move to electronic lab notebooks , New horizon for cancer innovation , and A personal touch: the role of bioprinting in drug discovery.

Drugs 130
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Medicare Warnings Stop Nursing Homes From Overusing Antipsychotic Meds

Drugs.com

FRIDAY, April 25, 2024 -- Warning letters sent by Medicare officials can prompt a decline in antipsychotic prescriptions for seniors with dementia, a new study finds.Letters sent to heavy prescribers of quetiapine (Seroquel), the most popular.

Nurses 111
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Test reveals mice think like babies

Science Daily: Pharmacology News

Are mice clever enough to be strategic? A neuroscientist who studies learning in humans and animals, and who has long worked with mice, wondered why rodents often performed poorly in tests when they knew how to perform well. With a simple experiment, and by acting as 'a little bit of a mouse psychologist,' he and his team figured it out.

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The Biotech Startup Contraction Continues… And That’s A Good Thing

LifeSciVC

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest quarterly pace in eight years during 1Q 2024. With just over 60 new biotechs raising their first round of financing, the sector’s company formation activity has slowed 50-60% from its historic peak in 2021.

DNA 109
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BenevolentAI to reduce staff by 30% in business reshuffle

Drug Discovery World

BenevolentAI has announced it will be reducing headcount by around 30% and closing its US office as part of a change of focus in its business priorities. The company says it will focus on its AI-driven drug discovery collaboration and proprietary pipeline, believing these will bring the greatest potential return for shareholders. Work on the Knowledge Exploration Tools will cease, due to the investment needed to fully commercialise this SaaS product and the estimated timeframe to see a potential

Licensing 130
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Clients Got HIV Through 'Vampire Facial' Microneedling Treatments

Drugs.com

FRIDAY, April 26, 2024 (HealthDay) -- Between 2018 and the spring of 2023, a cluster of clients who had gotten 'vampire facial' microneedling skin treatments at a New Mexico spa were diagnosed with HIV, probably via poorly cleaned instruments, a new.

Treatment 111
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Using stem cell-derived heart muscle cells to advance heart regenerative therapy

Science Daily: Pharmacology News

Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. However, the risk of arrhythmias following this procedure is reportedly high. In a recent study, researchers tested a novel approach that involves injecting 'cardiac spheroids,' cultured from human stem cells, directly into damaged ventricles.

Therapies 110
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Bristol Myers to cut 6% of workforce, trim drug pipeline

BioPharma Drive: Drug Pricing

The layoffs will impact some 2,200 employees, the company said, as it repositions its business ahead of looming patent expirations for top-selling products.

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AI drug discovery company Xaira launches with $1b investment

Drug Discovery World

Xaira Therapeutics, a joint incubation by ARCH Venture Partners and Foresite Labs, has launched with more than $1 billion of committed capital from lead investors. Xaira is building a platform for drug discovery and development that it hopes will advance multiple drug programmes and unlock biological understanding to inform future discovery. The company was co-founded by Dr David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington Sch

Drugs 130
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FDA Approves New Antibiotic Against UTIs, Pivya (pivmecillinam)

Drugs.com

THURSDAY, April 25, 2024 -- As many patients already know, urinary tract infections (UTIs) can recur despite the use of antibiotics. So, it's welcome news that the U.S. Food and Drug Administration on Wednesday approved Pivya (pivmecillinam) to.

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5 Thoughts on SUGCON Europe 2024 in Dublin, Ireland

Perficient: Drug Development

SUGCON (Sitecore User Group Conference) Europe 2024 was the second SUGCON I’ve attended, with the first just being six months ago in Minneapolis. There are few things that remind me how much I love my job more than being surrounded by the Sitecore Community. I’ve developed real friendships with folks from literally every corner of the world and it’s only once or twice a year we get the whole “Sitecore Family” together.